Abstract：
BACKGROUND AND AIMS:To explore hepatoprotective action of curcumin (CMN, a bioflavonoid) on oxaliplatin (Oxa)-triggered mitochondrial oxidative stress and respiratory chain complexes in liver of rats. Oxa is a ubiquitously utilized platinum-based chemotherapeutic agent commonly used for the treatment of colorectal cancer. Mitochondria have recently emerged as targets for anticancer drugs in several kinds of toxicity including hepatotoxicity that can lead to neoplastic disease. There is a dearth of evidence involving the role of mitochondria in mediating Oxa-evoked hepatotoxicity and its underlying mechanism is still debatable. METHODS:The study was performed in mitochondria isolated from liver of Wistar rats. Oxa (200 μg/mL) and CMN (5 μmol) were incubated under in vitro conditions. RESULTS:Oxa evoked a significant increase in the membrane lipid peroxidation (LPO) levels, protein carbonyl (PC) contents, decrease in reduced glutathione (GSH) and nonprotein thiol (NP-SH) levels. Oxa also caused a marked decline in the activities of enzymatic antioxidants and respiratory chain enzymes (I, II, III and V) in liver mitochondria. CMN pre-treatment significantly prevented the activities of enzymatic antioxidants and mitochondrial respiratory chain enzymes. CMN also restored the LPO and PC contents, GSH and NP-SH levels in liver mitochondria. CONCLUSION:CMN intake might be effective in regulation of Oxa-evoked mitotoxicity during chemotherapy. Moreover, it is included in the armamentarium for anticancer agent-induced oxidative stress.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Waseem M,Parvez S,Tabassum Hdoi
10.1016/j.arcmed.2017.01.010subject
Has Abstractpub_date
2017-01-01 00:00:00pages
55-63issue
1eissn
0188-4409issn
1873-5487pii
S0188-4409(17)30027-9journal_volume
48pub_type
杂志文章abstract：BACKGROUND:TCF, TPF/YY1, and the Sp family are specific transcription factors that bind sequences found within the uteroglobin (UG) gene promoter region that are necessary for transcription. To date, UG gene expression and regulation in vivo are not fully understood. The purpose of this study was to assess the expressi...
journal_title：Archives of medical research
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abstract：BACKGROUND:Recently, the Expert Committee of the American Diabetes Association proposed to decrease the lower limit for normal fasting plasma glucose (FPG) levels to 5.6 mmol/L. In this regard, the aim of this study was to determine the effect of lowering the criterion for normal FPG on the identification of subjects w...
journal_title：Archives of medical research
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journal_title：Archives of medical research
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journal_title：Archives of medical research
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journal_title：Archives of medical research
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abstract：BACKGROUND AND AIMS:Metabolic syndrome (MetS) is a disorder that includes a cluster of several risk factors for the development of type 2 diabetes and cardiovascular disease. The R230C variant of the ABCA1 gene has been associated with low HDL-cholesterol in several studies, but its association with MetS in children re...
journal_title：Archives of medical research
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journal_title：Archives of medical research
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doi：
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journal_title：Archives of medical research
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更新日期：1993-04-01 00:00:00
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journal_title：Archives of medical research
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2012.08.014
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journal_title：Archives of medical research
pub_type： 杂志文章,评审
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2011.09.010
更新日期：2011-10-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：
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journal_title：Archives of medical research
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journal_title：Archives of medical research
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2006.08.010
更新日期：2007-01-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章,meta分析
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更新日期：2012-07-01 00:00:00
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journal_title：Archives of medical research
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doi：
更新日期：1994-10-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2016.07.005
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Previous studies demonstrated that (99m)Tc-labeled-ubiquicidin 29-41 ((99m)Tc-UBI 29-41) imaging is an accurate method for detection of bacterial infections. This study was conducted to evaluate the clinical use of (99m)Tc-UBI 29-41 for detection of mediastinitis after cardiac surgery. METHODS:Thirteen pati...
journal_title：Archives of medical research
pub_type： 杂志文章
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更新日期：2008-11-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Acute myocardial infarction (AMI) is a leading cause of death in Mexico. Atherogenic lipid profile is a key component in AMI. Thus, it is imperative to find drug therapies able to reduce atherogenic lipids in AMI patients and prevent subsequent myocardial infarctions. AIM OF THE STUDY:To investigate the eff...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2019.08.002
更新日期：2019-05-01 00:00:00
abstract：BACKGROUNDS:Rheumatoid arthritis (RA) is a systemic autoimmune disease that confers one of the strongest risks for cardiovascular disease (CVD) morbidity and mortality than in general population. Pulse wave velocity (PWV) and augmentation index (AIx) are composite measures of arterial stiffness (AS) and associated with...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2019.10.010
更新日期：2019-10-01 00:00:00
