Abstract:
BACKGROUND:Previous studies demonstrated that (99m)Tc-labeled-ubiquicidin 29-41 ((99m)Tc-UBI 29-41) imaging is an accurate method for detection of bacterial infections. This study was conducted to evaluate the clinical use of (99m)Tc-UBI 29-41 for detection of mediastinitis after cardiac surgery. METHODS:Thirteen patients with suspected mediastinitis after cardiac surgery were included. Qualitative and semiquantitative analyses of (99m)Tc-UBI 29-41 images were performed. Mediastinitis was confirmed by bacterial culture. RESULTS:Qualitative analysis correctly identified the infection in 5/6 patients with mediastinitis. For observer 1, there were five true-positive results, six true-negative results, one false-positive result and one false-negative result (sensitivity: 83%, specificity: 85%, positive predictive value: 83%, negative predictive value: 85%, and overall diagnostic accuracy: 84%). For observer 2, there were five true-positive results, five true-negative results, two false-positive results and one false-negative result (sensitivity: 83%, specificity: 71%, positive predictive value: 71%, negative predictive value: 83%, and overall diagnostic accuracy: 76%). Agreement between observers was 0.847 (SE=0.145, p=0.002). Semiquantitative analysis showed a higher mediastinum uptake of the (99m)Tc-UBI 29-41 in patients with mediastinitis than that derived from patients without mediastinitis. Mean uptake of (99m)Tc-UBI 29-41 was 60.4+/-10.3 counts/pixel and 47.4+/-5.5 counts/pixel, respectively (p=0.01). At the threshold value of > or =57 counts/pixel using ROC analysis, the sensitivity, specificity, positive predictive value, negative predictive value and overall diagnostic accuracy for detecting patients with mediastinitis were 83, 100, 100, 87, and 92%, respectively (p=0.02; 95% CI: 0.65-1.10%). CONCLUSIONS:(99m)Tc-UBI 29-41 imaging yielded fast and promising first results for patients with suspected mediastinitis after cardiac surgery and, as such, deserves further investigation.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Vallejo E,Martinez I,Tejero A,Hernandez S,Jimenez L,Bialostozky D,Sanchez G,Ilarraza H,Ferro-Flores Gdoi
10.1016/j.arcmed.2008.09.002subject
Has Abstractpub_date
2008-11-01 00:00:00pages
768-74issue
8eissn
0188-4409issn
1873-5487pii
S0188-4409(08)00221-Xjournal_volume
39pub_type
杂志文章abstract:BACKGROUND AND AIMS:Extended-spectrum β-lactamase (ESBLs) production is still the most frequent mechanism of resistance to cephalosporins in gram-negative bacteria. The aim of the study was to identify the types of ESBL-producing Enterobacteriaceae clinical isolates causing nosocomial infections in Mexico. METHODS:ESB...
journal_title:Archives of medical research
pub_type: 杂志文章,多中心研究
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abstract:BACKGROUND AND AIMS:The risks of insulin resistance and accelerated atherosclerosis are increased in chronic inflammatory diseases including rheumatoid arthritis (RA). Adipo-(cyto)kines are associated with insulin resistance, atherosclerosis and inflammation. This study aimed to determine serum adiponectin and vaspin l...
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abstract:BACKGROUND:Because lymphocytes from fragile X patients have been reported as hypersensitive to bleomycin-induced chromatid breaks and because the number of trinucleotide repeats in families with fragile X syndrome has a propensity to expand, we have investigated the possibility that fragile X cells may be hypersensitiv...
journal_title:Archives of medical research
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doi:10.1016/s0188-4409(01)00376-9
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abstract:BACKGROUND:Cellular events in cisplatin-mediated nephrotoxicity include apoptosis induction, decreased protein synthesis, changes in the subcellular redistribution of Bax mitochondrial dysfunction, DNA injury, increased lipid peroxidation, depletion of glutathione and decrease in enzymatic activity of renal antioxidant...
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abstract:BACKGROUND AND AIMS:Thyroid hormones exert important effects on heart remodeling through mir-208. The process may have a role in myocardial changes in chronic kidney disease where thyroid abnormalities are common. In this study the effect of T4 supplementation on left ventricle (LV) remodeling in 5/6 nephrectomized rat...
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abstract::Behavioral changes and adherence to pharmacological treatment are essential for improving the prognosis in chronic illness. Lack of adherence to treatment is a common problem in every practice and many patients drop out of care prematurely. The present article is a review of our knowledge regarding adherence to treatm...
journal_title:Archives of medical research
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abstract:BACKGROUND:Wind instrument playing requires a strenuous respiratory activity. Previous studies investigating effect of wind instrument playing on pulmonary function are equivocal. METHODS:In the present study, 34 male, non-smoker wind players in a military band were compared with 44 healthy non-smoker males by pulmona...
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journal_title:Archives of medical research
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更新日期:2000-01-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2003.07.004
更新日期:2004-01-01 00:00:00
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journal_title:Archives of medical research
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更新日期:1992-01-01 00:00:00
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journal_title:Archives of medical research
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journal_title:Archives of medical research
pub_type: 杂志文章,评审
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更新日期:1996-07-01 00:00:00
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更新日期:1996-01-01 00:00:00
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journal_title:Archives of medical research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Archives of medical research
pub_type: 杂志文章,评审
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更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:This study aims to investigate the efficacy of fluoxetine and paroxetine on the levels of depression-anxiety, quality of life, disability, and metabolic control in type II diabetes mellitus (DM) patients. METHODS:The patients were first applied the Hospital Anxiety-Depression Scale (HADS). After a psychiatr...
journal_title:Archives of medical research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-03-01 00:00:00
abstract:BACKGROUND AND AIMS:The major limiting factor in therapeutic application of mesenchymal stem cells (MSCs) is their high vulnerability during the early days of transplantation. Hence, researchers have been encouraged to find various strategies to make the cells resistant to different stresses before and after transplant...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2013.03.006
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:The present study was designed to examine whether resveratrol, a potent antioxidant, protects against renal ischemia-reperfusion (I/R) injury. METHODS:Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 6 h of reperfusion. Resveratrol (RVT, 30 m...
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更新日期:2006-10-01 00:00:00