Prognostic Significance of Serum CD26 Concentration in Patients with Esophageal Squamous Cell Carcinoma.


BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in developing countries. The aim of the study was to determine the association between serum CD26 concentration and outcome of patients with ESCC. METHODS:A total of 183 patients with ESCC and 254 healthy controls were selected. Blood samples were obtained from the participants. The serum level of CD26 was detected using a commercial enzyme-linked immunosorbent assay kit. All patients were followed for 4 years unless they died of ESCC during the follow-up period. RESULTS:Compared with the controls, serum CD26 levels in the patients decreased at admission (p <0.001), recovered to normal 1 month after resection (p = 0.087), and declined again at the time of tumor relapse (p <0.001). During the follow-up period, 107 patients died of ESCC and 76 patients survived. Multivariate logistic regression analysis revealed that the low serum level of CD26 (<530 pg/mL) was associated with poor prognosis in the patients (OR: 5.42, 95% CI: 2.91-8.41). Survival analysis also suggested that the patients with high serum level of CD26 (≥530 pg/mL) had a survival advantage compared with the patients with low serum level of CD26 (<530 pg/mL) (p <0.001). CONCLUSIONS:Serum CD26 concentration might be an independent prognostic indicator in patients with ESCC. It might be also useful to detect recurrent tumor in postoperative patients.


Arch Med Res


Xinhua W,Xiangting Q,Lingling C,Guohong L




Has Abstract


2016-05-01 00:00:00














  • Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps.

    abstract:BACKGROUND:The aim of this study was to determine concentrations of tumor necrosis factor-alpha (TNF-alpha) in normal, painful, and asymptomatic human dental pulps. METHODS:Pulps were obtained from three groups of teeth, including healthy teeth, asymptomatic teeth with caries and/or large restoration, and symptomatic ...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Pezelj-Ribaric S,Anic I,Brekalo I,Miletic I,Hasan M,Simunovic-Soskic M

    更新日期:2002-09-01 00:00:00

  • A diabetic retinopathy screening program as a strategy for blindness prevention.

    abstract::The most frequent cause of preventable blindness in adults, in the developed world, is diabetic retinopathy (DR). The early treatable phase of this complication is clinically silent. In order to institute effective laser photocoagulation and prevention of blindness, timely detection is crucial. Consequently there is a...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: González Villalpando C,González Villalpando ME,Martínez Díaz S,Rivera Martínez D,Arredondo Pérez B,Islas Andrade S,Stern MP

    更新日期:1997-04-01 00:00:00

  • Hashimoto's thyroiditis, but not treatment of hypothyroidism, is associated with altered TGF-beta1 levels.

    abstract:BACKGROUND:Although the role of cytokines in the development of Hashimoto's thyroiditis has already been established, its pathogenesis has not yet been clearly elucidated. The aim of our study was to investigate serum transforming growth factor-beta1 (TGF-beta1) levels in patients with Hashimoto's thyroiditis as well a...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Akinci B,Comlekci A,Yener S,Bayraktar F,Demir T,Ozcan MA,Yuksel F,Yesil S

    更新日期:2008-05-01 00:00:00

  • Association of NAT2 polymorphisms with type 2 diabetes in a population from Bosnia and Herzegovina.

    abstract:BACKGROUND AND AIMS:N-acetyltransferase 2 (NAT2) is a drug-metabolizing enzyme, which is genetically variable in human populations. Polymorphisms in the NAT2 gene have been associated with drug efficacy and toxicity as well as disease susceptibility. Recently, an association of NAT2 gene variation with risk of type 2 d...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Semiz S,Dujic T,Ostanek B,Velija-Asimi Z,Prnjavorac B,Bego T,Malenica M,Mlinar B,Heljic B,Marc J,Causevic A

    更新日期:2011-05-01 00:00:00

  • Pattern of childhood cancer mortality in Mexico.

    abstract::Public and governmental concern regarding increasing cancer mortality trends in children in Mexico led us to investigate the current situation of childhood cancer in this country, as well as to discuss the reasons for which no decline in total and childhood cancer mortality has been documented during the past decades....

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Abdullaev FI,Rivera-Luna R,Roitenburd-Belacortu V,Espinosa-Aguirre J

    更新日期:2000-09-01 00:00:00

  • Spermicidal activity of bivittoside D from Bohadschia vitiensis.

    abstract:BACKGROUND:A recent revelation about increased susceptibility to HIV by use of nonoxynol-9 (N-9) has called for identification of novel molecules with potent sperm-attenuating activity and lower side-effect profile, as suitable alternatives. The present study was designed to investigate spermicidal activity in Bohadsch...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Lakshmi V,Saxena A,Mishra SK,Raghubir R,Srivastava MN,Jain RK,Maikhuri JP,Gupta G

    更新日期:2008-10-01 00:00:00

  • Comparison of pyruvate kinase variants from breast tumor and normal breast.

    abstract:BACKGROUND:Pyruvate kinase isozymes in human breast tumor tissue were compared in this study with normal human breast tissue. Two forms of pyruvate kinase present in normal and tumor human breast were purified by ammonium sulfate precipitation, dialysis, gel filtration, ion exchange, and affinity chromatography. Molecu...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Yilmaz S,Ozan S,Ozercan IH

    更新日期:2003-07-01 00:00:00

  • Studies on nap sleep in young students. Relationships between polygraphic data and the occurrence of dreams in replacing naps.

    abstract:BACKGROUND:Afternoon nap sleep was studied in 32 young male medical students who take customary naps to replace loss in nocturnal sleep. METHODS:From 16 subjects, a group called dreamers was formed, and the other 16 individuals were grouped as non-dreamers. Polygraphic recordings lasting 30 min were done at a fixed ti...

    journal_title:Archives of medical research

    pub_type: 临床试验,杂志文章


    authors: Islas-Marroquín J,Delgado-Brambila HA

    更新日期:1998-07-01 00:00:00

  • Induction of macrophage killing of Leishmania donovani by human CD4+ T cell clones.

    abstract::Immunity in leishmaniasis is mediated by T cells, but protective responses in humans have not been fully defined. In this study, the functional activity of CD4+ T cell clones derived from an immune individual was investigated to identify potentially protective responses. The T cells proliferated and produced interfero...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Melby PC,Valencia-Pacheco G,Andrade-Narváez F

    更新日期:1996-01-01 00:00:00

  • Effects of corn feeding and protein restriction on free amino acid concentration in the rat cerebellum.

    abstract::To determine the effect of low protein and corn-based diets on the maturation of cerebellum, three groups of young rats were fed during a period of 6 weeks with different diets; 23 and 8% of protein (Purina-Chow base) and a corn-based diet (8% protein). At the end of that period, the concentration of free amino acids ...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Velázquez A,Rosa del Angel A,Feria-Velasco A

    更新日期:1993-04-01 00:00:00

  • Etiological review of hirsutism in 250 patients.

    abstract::Two hundred fifty women with hirsutism were studied, with a mean age of 25.5 years (ranging from 13 to 38 years). The evolution of hirsutism varied from 3 months to 13 years, being minimal in 82 patients (33%), mild to 101 (40%), moderate in 56 (23%) and severe in the remaining 11 women (4%). Polycystic ovary syndrome...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Morán C,Tapia MC,Hernández E,Vázquez G,García-Hernández E,Bermúdez JA

    更新日期:1994-10-01 00:00:00

  • Emerging noninvasive biomarkers for early detection of Alzheimer's disease.

    abstract::Alzheimer's disease (AD) diagnosis still depends on the triad of clinical, imaging and neuropsychological testing. The development of accurate, easy to use and inexpensive biological markers for AD is a long-standing aspiration for researchers and the medical community. Here we describe some of the recent advances in ...

    journal_title:Archives of medical research

    pub_type: 杂志文章,评审


    authors: Guzmán-Martínez L,Farías GA,Maccioni RB

    更新日期:2012-11-01 00:00:00

  • Molsidomine prevents cisplatin-induced hepatotoxicity.

    abstract:BACKGROUND AND AIMS:Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive oxygen radical species are involved with the pathophysiology of cisplatin-induced hepatotoxicity. Molsidomine (MOL) can exert antioxidant an...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Bentli R,Parlakpinar H,Polat A,Samdanci E,Sarihan ME,Sagir M

    更新日期:2013-10-01 00:00:00

  • Evaluation of the vestibular autorotation test (VAT) for measuring vestibular oculomotor reflex in clinical research.

    abstract:BACKGROUND:A method is needed to measure parameters of vertigo and disequilibrium. Our objective was to ascertain whether the vestibular autorotation test (VAT) gives numerical data on the vestibular oculomotor reflex (VOR) that are useful for clinical research. METHODS:A VAT was carried out on 17 healthy young volunt...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Corvera J,Corvera-Behar G,Lapilover V,Ysunza A

    更新日期:2000-07-01 00:00:00

  • The positive experience of screening quality among users of a cervical cancer detection center.

    abstract:BACKGROUND:Our objective was to determine the main factors associated with increased utilization of a cervical cancer screening program (CCSP) in a population with a high mortality rate due to cervical cancer. METHODS:A population-based study was carried out in the Mexican state of Morelos, Mexico. The study populatio...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Lazcano-Ponce EC,Moss S,Cruz-Valdez A,de Ruíz PA,Martínez-León CJ,Casares-Queralt S,Hernández-Avila M

    更新日期:2002-03-01 00:00:00

  • Vildagliptin and G-CSF Improved Angiogenesis and Survival after Acute Myocardial Infarction.

    abstract:BACKGROUND:Myocardial infarction (MI) is one of the most important diseases that has stimulated interest in understanding cardiac function recovery. SDF-1 is a chemotactic factor and a pro-angiogenic molecule; SDF-1 degradation is inhibited by dipeptidyl peptidase-4 (DPP4) inhibitors, such as vildagliptin. We investiga...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Li M,Wang Z,Xia H,Yu L,Hu Z

    更新日期:2019-04-01 00:00:00

  • Thyroid hormone and insulin-like growth factor-I in patients with multiple myeloma treated with melphalan and prednisone.

    abstract:BACKGROUND:The relationship between endocrine regulation and immune system has recently become the subject of intense investigations. The aim of this study was the comparative assessment of serum levels of selected hormones and insulin-like growth factor-I (IGF-I) in patients with multiple myeloma (MM) during applied t...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Hrycek A,Gruszka A

    更新日期:2006-01-01 00:00:00

  • Gene therapy: theoretical and bioethical concepts.

    abstract::Gene therapy holds great promise. Somatic gene therapy has the potential to treat a wide range of disorders, including inherited conditions, cancers, and infectious diseases. Early progress has already been made in the treatment of a range of disorders. Ethical issues surrounding somatic gene therapy are primarily tho...

    journal_title:Archives of medical research

    pub_type: 杂志文章,评审


    authors: Smith KR

    更新日期:2003-07-01 00:00:00

  • Interactions of phagocytic cells with Candida and other opportunistic fungi.

    abstract::Phagocytic host defense mechanisms play a pivotal role in the prevention and containment of invasive, disseminated candidiasis, aspergillosis, and other opportunistic mycoses. The specific processes involved depend upon both the species, growth phase, and surface properties of the fungal target and the type and differ...

    journal_title:Archives of medical research

    pub_type: 杂志文章,评审


    authors: Diamond RD

    更新日期:1993-01-01 00:00:00

  • Relationship between A-3826G polymorphism in the promoter of the uncoupling protein-1 gene and high-density lipoprotein cholesterol in Japanese individuals: a cross-sectional study.

    abstract:BACKGROUND:A-3826G polymorphism within the promoter region of the uncoupling protein-1 (UCP-1) gene is possibly involved in the pathophysiology of obesity and metabolic disorders. However, the effects of UCP-1 A-3826G polymorphism on high-density lipoprotein cholesterol (HDL-C), a major contributor to atherosclerotic d...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Kotani K,Sakane N,Saiga K,Adachi S,Shimohiro H,Mu H,Kurozawa Y

    更新日期:2008-01-01 00:00:00

  • Associations for lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene and coronary artery disease in an Indian population.

    abstract:BACKGROUND AND AIMS:Peroxisome proliferator activated receptor-gamma (PPARgamma) and lipoprotein lipase (LPL) genes are important in pathways of triglyceride metabolism, insulin resistance and adipogenesis. We hypothesized that polymorphisms of PPARgamma Pro12Ala, LPL HindIII and LPL Ser447X influence severity of coron...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: AshokKumar M,Veera Subhashini NG,Kanthimathi S,SaiBabu R,Ramesh A,Cherian KM,Emmanuel C

    更新日期:2010-01-01 00:00:00

  • Epidemiologic panorama of stomach cancer mortality in Mexico.

    abstract:BACKGROUND:Annually, there are more than 6 million deaths from a type of malignant neoplasia worldwide. In developing countries, the highest rates of incidence of malignant neoplasias are uterine cervical cancer, stomach, lung, esophagus, pharynx, and liver cancers. Recent estimates on the incidence of cancer worldwide...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Tovar-Guzmán V,Hernández-Girón C,Barquera S,Rodríguez-Salgado N,López-Carrillo L

    更新日期:2001-07-01 00:00:00

  • Soluble ICAM 1 and VCAM 1 Blood Levels Alert on Subclinical Atherosclerosis in Non Smokers with Asymptomatic Metabolic Syndrome.

    abstract:BACKGROUND:Metabolic syndrome (MetS) is a heterogeneous clinical entity associated with insulin resistance, low-grade proinflammatory balance and impaired endothelial function, accelerating atherosclerosis. Atherosclerotic lesions worsen with age, smoking and co-morbidities, making it difficult to accurately diagnose t...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Varona JF,Ortiz-Regalón R,Sánchez-Vera I,López-Melgar B,García-Durango C,Castellano Vázquez JM,Solís J,Fernández-Friera L,Vidal-Vanaclocha F

    更新日期:2019-02-01 00:00:00

  • Lipid profile and anticardiolipin antibodies in Behcet's disease.

    abstract:BACKGROUND:Behcet's disease (BD) is a multisystem disorder characterized by a relapsing inflammatory process of unknown etiology. It is well known that atherothrombosis in systemic inflammatory disorders is closely related to coagulation and lipid metabolism abnormalities. The purpose of this study was to investigate s...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Musabak U,Baylan O,Cetin T,Yesilova Z,Sengul A,Saglam K,Inal A,Kocar IH

    更新日期:2005-07-01 00:00:00

  • Reaching targets for mineral metabolism clinical practice guidelines and its impact on outcomes among Mexican chronic dialysis patients.

    abstract:BACKGROUND AND AIMS:An increasing number of studies have been published concerning meeting targets of clinical guidelines for different aspects of the diagnosis and treatment of patients with end-stage renal disease. Most of these studies have shown that guideline recommendations are not always satisfied, and results o...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Paniagua R,Ventura MD,Ávila-Díaz M,Hinojosa-Heredia H,Méndez-Duran A,Cisneros A,Gómez AM,Cueto-Manzano A,Trinidad P,Obrador GT,García-López E,Lindholm B

    更新日期:2013-04-01 00:00:00

  • Polymorphism C1114G of gene encoding the cardiac regulator of G-protein signaling 2 may be associated with number of episodes of neurally mediated syncope.

    abstract:BACKGROUND AND AIMS:The cardiac regulator of G-protein signaling 2 (RGS2) negatively regulates G-protein-coupled receptor signaling. The C1114G polymorphism reduces RGS2 gene expression. This molecular disorder may be one of the important factors influencing progress of neurally mediated syncope. The aim of the study w...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Lelonek M,Pietrucha T,Matyjaszczyk M,Goch JH

    更新日期:2009-04-01 00:00:00

  • Changes in insulin sensitivity, secretion and glucose effectiveness during menstrual cycle.

    abstract:BACKGROUND:Several clinical conditions suggest an effect of sex steroids on glucose homeostasis in women. Studies examining this phenomenon have yielded controversial results. METHODS:To investigate the effect of the menstrual cycle on insulin sensitivity, glucose effectiveness and acute insulin response to glucose us...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Escalante Pulido JM,Alpizar Salazar M

    更新日期:1999-01-01 00:00:00

  • Six Month Polypill Therapy Improves Lipid Profile in Patients with Previous Acute Myocardial Infarction: The Heart-Mex Study.

    abstract:BACKGROUND:Acute myocardial infarction (AMI) is a leading cause of death in Mexico. Atherogenic lipid profile is a key component in AMI. Thus, it is imperative to find drug therapies able to reduce atherogenic lipids in AMI patients and prevent subsequent myocardial infarctions. AIM OF THE STUDY:To investigate the eff...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Méndez-García LA,González-Chávez A,Trejo-Millán F,Navarrete-Zarco HU,Carrero-Aguirre M,Meléndez G,Chávez A,Escobedo G

    更新日期:2019-05-01 00:00:00

  • Vitamin C status, cervico-vaginal infection and premature rupture of amniotic membranes.

    abstract::A prospective study to evaluate the role of vitamin C and cervico-vaginal infection in the premature rupture of amniotic membranes (PROM) was designed. The leukocyte vitamin C levels of 44 pregnant women that did not consume vitamin supplements was evaluated at weeks 20, 28 and 32 of pregnancy. On each evaluation the ...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Casanueva E,Avila-Rosas H,Polo E,Tejero E,Narcio-Reyes ML,Pfeffer F

    更新日期:1995-01-01 00:00:00

  • Contemporary Applications of Fecal Microbiota Transplantation to Treat Intestinal Diseases in Humans.

    abstract::The intestinal microbiota comprise an important organ that plays a vital role in host digestion, development, energy maintenance, hemostasis, and immunity. Disruption of the gut microbial community due to diet, lifestyle, or antibiotic exposure increases susceptibility to chronic infection and disease. Fecal microbiot...

    journal_title:Archives of medical research

    pub_type: 杂志文章,评审


    authors: Staley C,Khoruts A,Sadowsky MJ

    更新日期:2017-11-01 00:00:00