Abstract:
BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in developing countries. The aim of the study was to determine the association between serum CD26 concentration and outcome of patients with ESCC. METHODS:A total of 183 patients with ESCC and 254 healthy controls were selected. Blood samples were obtained from the participants. The serum level of CD26 was detected using a commercial enzyme-linked immunosorbent assay kit. All patients were followed for 4 years unless they died of ESCC during the follow-up period. RESULTS:Compared with the controls, serum CD26 levels in the patients decreased at admission (p <0.001), recovered to normal 1 month after resection (p = 0.087), and declined again at the time of tumor relapse (p <0.001). During the follow-up period, 107 patients died of ESCC and 76 patients survived. Multivariate logistic regression analysis revealed that the low serum level of CD26 (<530 pg/mL) was associated with poor prognosis in the patients (OR: 5.42, 95% CI: 2.91-8.41). Survival analysis also suggested that the patients with high serum level of CD26 (≥530 pg/mL) had a survival advantage compared with the patients with low serum level of CD26 (<530 pg/mL) (p <0.001). CONCLUSIONS:Serum CD26 concentration might be an independent prognostic indicator in patients with ESCC. It might be also useful to detect recurrent tumor in postoperative patients.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Xinhua W,Xiangting Q,Lingling C,Guohong Ldoi
10.1016/j.arcmed.2016.07.005subject
Has Abstractpub_date
2016-05-01 00:00:00pages
299-303issue
4eissn
0188-4409issn
1873-5487pii
S0188-4409(16)30090-Xjournal_volume
47pub_type
杂志文章abstract:BACKGROUND AND AIMS:To explore hepatoprotective action of curcumin (CMN, a bioflavonoid) on oxaliplatin (Oxa)-triggered mitochondrial oxidative stress and respiratory chain complexes in liver of rats. Oxa is a ubiquitously utilized platinum-based chemotherapeutic agent commonly used for the treatment of colorectal canc...
journal_title:Archives of medical research
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abstract::A model of BALB/c mice was developed to determine the effects of zinc supplements on immune responses during certain stages of ontogeny. The mice received zinc acetate in drinking water concentrations of 500 and 1000 mg/l during the periods of gestation, lactation and postweaning. The sequence employed in this study w...
journal_title:Archives of medical research
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abstract:BACKGROUND:The present study was designed to examine whether resveratrol, a potent antioxidant, protects against renal ischemia-reperfusion (I/R) injury. METHODS:Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 6 h of reperfusion. Resveratrol (RVT, 30 m...
journal_title:Archives of medical research
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journal_title:Archives of medical research
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abstract::During the late 1940s, Alfred Jost demonstrated that mammalian sex differentiation begins in fetal testis, producing two factors necessary for the establishment of phenotypic males. Castrated embryos prior to testis differentiation led to phenotypic female differentiation. Jost proposed the existence of a testis-deter...
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journal_title:Archives of medical research
pub_type: 杂志文章,meta分析
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更新日期:2011-04-01 00:00:00
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doi:
更新日期:1992-04-01 00:00:00
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更新日期:2005-09-01 00:00:00
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journal_title:Archives of medical research
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更新日期:2003-03-01 00:00:00
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更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The relationship between endocrine regulation and immune system has recently become the subject of intense investigations. The aim of this study was the comparative assessment of serum levels of selected hormones and insulin-like growth factor-I (IGF-I) in patients with multiple myeloma (MM) during applied t...
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更新日期:2006-01-01 00:00:00