Abstract：
BACKGROUND:One of the most frequent malignancies in women worldwide is carcinoma of the uterine cervix. High-risk human papillomavirus (HPV) infection is considered the most important etiological factor of uterine cervical cancer. Our aim was to identify novel cellular genes that could potentially act as predictive molecular markers for human cervical cancer by means of cDNA arrays. METHODS:We used cDNA arrays to examine the expression profiles of six cell lines derived from human cervical cancer, three HPV+ tumor samples and three normal (HPV-) epithelium tissues. Data normalization was performed and the top overexpressed genes were obtained. Hierarchical cluster was performed and, to validate some of the differentially expressed genes between normal and carcinogenic samples, semi-quantitative RT-PCR, in situ hybridization and immunohistochemistry were performed in tissue samples. RESULTS:Four genes were demonstrated to be consistently overexpressed in invasive cervical cancer biopsies; three novel genes not previously related to cervical cancer: MMP10, Lamc2 and Claudin 1. Moreover, overexpression of IL6 and VEGF was corroborated. CONCLUSIONS:The identification of characteristic molecular changes in cervical cells by carcinogenesis and HPV infection can lead to a better understanding of cervical cancer. cDNA arrays are beginning to provide new possible molecular markers for prognosis and diagnosis. This technology could eventually help to elucidate the biological differences of the particular mechanisms associated with each different HPV-type infection and those with a poor prognosis.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Vázquez-Ortíz G,Ciudad CJ,Piña P,Vazquez K,Hidalgo A,Alatorre B,Garcia JA,Salamanca F,Peralta-Rodriguez R,Rangel A,Salcedo Mdoi
10.1016/j.arcmed.2005.04.016subject
Has Abstractpub_date
2005-09-01 00:00:00pages
448-58issue
5eissn
0188-4409issn
1873-5487pii
S0188-4409(05)00223-7journal_volume
36pub_type
杂志文章abstract：BACKGROUND AND AIMS:Thyroid hormones exert important effects on heart remodeling through mir-208. The process may have a role in myocardial changes in chronic kidney disease where thyroid abnormalities are common. In this study the effect of T4 supplementation on left ventricle (LV) remodeling in 5/6 nephrectomized rat...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2013.11.005
更新日期：2013-11-01 00:00:00
abstract：:In this study we evaluated the usefulness of ferruginous bodies (FB) quantification in lung digest and histologic sections from 40 patients with a history of exposure to inorganic dusts. The patients were matched with 40 cases without occupational exposure. The samples of peripheral lung tissue were digested and all F...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Cervical cancer (CC) is one of the principal public health problems in Mexico. The national mortality rate due to CC was estimated at 21.8 per 100,000 among women over 15 years old during 1994. Despite this high incidence little is known in Mexico about the risk factors for CC. The objectives of the study were to eval...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:Implantation is a complex spatio-temporal interaction between the genotypically different embryo and the mother. Success of this event requires the synchronization of development and effective biochemical communications from both sides. Chorionic gonadotropin (CG), which is a major embryonic signal in the primate, is ...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/s0188-4409(01)00330-7
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Antiepileptics including benzodiazepines have long been recognized to provoke seizures and precipitate status epilepticus occasionally. This has a special clinical importance in the case of diazepam because of its use as first choice medication in its management. This report is intended to highlight the clin...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(00)00043-6
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND AND AIMS:In previous studies, the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2) was shown to be associated with both lipid metabolism and longevity. We examined whether the polymorphism continued to be associated with abnormal levels of serum lipid/lipoprotein amon...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2011.09.010
更新日期：2011-10-01 00:00:00
abstract：:Nicorandil, the first clinically applied ATP-sensitive K+ channel (K+ATP) opener with nitrate property, has demonstrated cardioprotective effects in patients with multiples of heart diseases. However, it is unknown whether nicorandil has effects on left ventricular (LV) remodeling in rats with ischemic heart failure a...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2018.12.006
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Helicobacter pylori is the most common etiological factor of chronic infection worldwide. It has also been found in human dental plaques, mouth, saliva, tonsils and adenoid tissue, medial ear or nasal polyps and sinuses mucosa, as well in several benign and malignant lesions of the larynx and pharyn...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2011.12.005
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Cardiovascular (CV) risk factors are influenced by behavioral, cultural, and social factors, suggesting that acculturation plays a significant role in the emergency and growth of chronic disease. The objective of this study was to determine the relation between CV risk factors and the main components of accu...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.12.003
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:It is well documented that Giardia duodenalis undergoes surface antigenic variation both in vivo and in vitro. Proteins involved have been characterized and referred to as VSP (variable surface protein). METHODS:Two cloned cDNA inserts of 0.45 and 1.95 kb were obtained from G. duodenalis expression library ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2003.12.005
更新日期：2004-05-01 00:00:00
abstract：:Proteolytic activity was measured in lysates of four axenic and five xenic cultures of different strains of pathogenic E. histolytica, and in five non-pathogenic strains ("E. dispar") growing in xenic culture. There was no significant difference in total proteolytic activity, using either gelatin or albumin as substra...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Mycoplasmal pneumonia of swine causes considerable economic losses in porciculture. Diverse agents, such as environmental stress and infectious microorganisms, increase the possibility of infection, and the damage to pulmonary tissue when the infection is established. It is known that Mycoplasma hyopneumoniae has an i...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:Several clinical conditions suggest an effect of sex steroids on glucose homeostasis in women. Studies examining this phenomenon have yielded controversial results. METHODS:To investigate the effect of the menstrual cycle on insulin sensitivity, glucose effectiveness and acute insulin response to glucose us...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-0128(98)00008-6
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Few studies have described the association between hepcidin levels and cardiometabolic risk in the general population and more so by considering robust adjustment for confounding factors. Therefore, the aim of the present study was to investigate the associations between circulating hepcidin and ant...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2015.07.007
更新日期：2015-08-01 00:00:00
abstract：AIM OF THE STUDY:Rutin and Silibinin are active flavonoid compounds, well-known for possessing multiple biological activities. We have studied how Rutin and Silibinin in combination modulate wide range intracellular signaling cascades as evidenced by in-vitro research. Data obtained from preclinical studies provide evi...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2018.09.008
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND AND AIMS:Metabolic syndrome (MetS) is a disorder that includes a cluster of several risk factors for the development of type 2 diabetes and cardiovascular disease. The R230C variant of the ABCA1 gene has been associated with low HDL-cholesterol in several studies, but its association with MetS in children re...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2015.07.008
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:The main objectives in this work were to determine whether the relationship between serum testosterone concentration and electroencephalography (EEG) develop mental change observed in human males is also present in Macaca mulatta and, if so, to determine which frequency bands are involved and which regions c...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2004.06.003
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND AND AIMS:Childhood acute lymphoblastic leukemia (ALL) is the leading cause of childhood cancer-related deaths worldwide. Multiples studies have shown that ALL seems to be originated by an interaction between environmental and genetic susceptibility factors. The ARID5B polymorphisms are among the most reprodu...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2016.12.003
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Lung adenocarcinoma (LAC) is a major worldwide cause of death by cancer, it shows high aggressiveness, functional decline, systemic compromise and severe cachexia, which might be counteracted by dietary redox-active phytochemicals. Therefore, our aim was to establish the anticancer effects of the oral intake...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2019.11.006
更新日期：2020-01-01 00:00:00
abstract：:A matrix metalloproteinase with selective affinity for collagen was identified and partially purified from normal rat kidney. A two-step purification procedure consisting of gel filtration and affinity chromatography on Sepharose 4B-collagen resulted in an increase in specific activity of more than 3,000 times. The pa...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Phosphodiesterases 5 and 9 (PDE5, PDE9) are enzymes responsible for regulating second messenger signaling by hydrolyzing 3',5' cyclic guanosine monophosphate (cGMP). PDE isoforms are deregulated in some types of human cancer. The present study was carried out to evaluate the expression of phosphodie...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2012.08.006
更新日期：2012-08-01 00:00:00
abstract：:Familial isolated glucocorticoid deficiency is a form of potentially lethal hereditary unresponsiveness to ACTH that manifests as primary adrenal insufficiency, usually without mineralocorticoid deficiency. Affected children commonly present with hyperpigmentation, recurrent hypoglycemia, chronic asthenia and failure ...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/s0188-0128(99)00057-3
更新日期：1999-11-01 00:00:00
abstract：:Acute myeloid leukemia (AML) is a clonal disorder defined by the accumulation of abnormally differentiated myeloid cells that are not mature; any myeloid lineage can be affected and the extent of maturation of the leukemia blasts can also vary. Because mature blast cells of AML have very limited proliferative capacity...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2003.08.007
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Streptococcus pneumoniae is the leading cause of acute otitis media, pneumonia, meningitis, and sepsis. The heptavalent pneumococcal conjugate vaccine (PCV7) was incorporated into the national immunization program in Mexico in 2008. The aim of the study was to analyze the frequency of S. pneumoniae ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2015.02.004
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:PCI is an expensive procedure in our population and it implies a huge cost for the institutions and National Health Service. AIM OF THE STUDY:The main objective was to evaluate the technical and biological success of two stents designed in Mexico. METHODS:Ten York pigs, 4-6 months of age, underwent implant...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.03.016
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to determine concentrations of tumor necrosis factor-alpha (TNF-alpha) in normal, painful, and asymptomatic human dental pulps. METHODS:Pulps were obtained from three groups of teeth, including healthy teeth, asymptomatic teeth with caries and/or large restoration, and symptomatic ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(02)00396-x
更新日期：2002-09-01 00:00:00
abstract：:During the past few years, an increasing set of evidence has supported the major role of deregulation of the interaction patterns between glial cells and neurons in the pathway toward neuronal degeneration. Neurons and glial cells, together with brain vessels, constitute an integrated system for brain function. Inflam...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2007.10.001
更新日期：2008-01-01 00:00:00
abstract：:Behavioral changes and adherence to pharmacological treatment are essential for improving the prognosis in chronic illness. Lack of adherence to treatment is a common problem in every practice and many patients drop out of care prematurely. The present article is a review of our knowledge regarding adherence to treatm...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2004.12.001
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:Inflammation is a risk factor for mortality in patients with chronic renal failure (CRF). Prevention of extracellular fluid volume expansion and the use of certain drugs such as pentoxifylline (PF) may reduce inflammation and oxidative stress. The aim of this study is to analyze the effect of dietary sodium ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2006.08.010
更新日期：2007-01-01 00:00:00
abstract：:The number of patients requiring lung transplantation is increasing, with a significant unmet demand for grafts. Ex vivo lung perfusion has been developed to increase graft recruitment. The major complications of lung transplantation include chronic allograft dysfunction (CLAD) whose cumulative incidence ranges from 4...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2015.03.004
更新日期：2015-04-01 00:00:00
