Abstract：
BACKGROUND AND AIMS:Childhood acute lymphoblastic leukemia (ALL) is the leading cause of childhood cancer-related deaths worldwide. Multiples studies have shown that ALL seems to be originated by an interaction between environmental and genetic susceptibility factors. The ARID5B polymorphisms are among the most reproducible ALL associated-risk alleles in different populations. The aim of the present study was to examine the contribution of ARID5B, CEBPE, and PIP4K2 risk alleles for the development of ALL in children from Mexico City and Yucatan, Mexico. METHODS:A study was conducted with a total of 761 unrelated subjects. Two hundred eighty five ALL cases (111 from Yucatan and 174 from Mexico City) and 476 healthy subjects. Genotyping included the rs7088318 (PIP4K2A), rs10821936 (ARID5B), rs7089424 (ARID5B) and rs2239633 (CEBPE) polymorphisms. RESULTS:Associations between ALL and rs10821936 and rs7089424 ARID5B SNPs were found (OR = 1.9, 95% CI (1.5-2.4) and OR = 2.0, 95% CI (1.6-2.5), respectively). Moreover, a higher risk was observed in the homozygous risk genotypes of carriers from Mexico City (OR = 3.1, 95% CI (2.0-4.9) and OR 3.1, CI 95% (2.0-4.8), respectively). Otherwise, the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk. CONCLUSIONS:Our analysis suggests that ARID5B confers risk for childhood ALL in a Mexican population.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Bekker-Méndez VC,Núñez-Enríquez JC,Torres Escalante JL,Alvarez-Olmos E,González-Montalvoc PM,Jiménez-Hernández E,Sansón AM,Leal YA,Ramos-Cervantes MT,Guerra-Castillo FX,Ortiz-Maganda MP,Flores-Lujano J,Pérez-Saldivar ML,Velazqudoi
10.1016/j.arcmed.2016.12.003subject
Has Abstractpub_date
2016-11-01 00:00:00pages
623-628issue
8eissn
0188-4409issn
1873-5487pii
S0188-4409(16)30220-Xjournal_volume
47pub_type
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