Abstract:
BACKGROUND:The aim of this study was to determine concentrations of tumor necrosis factor-alpha (TNF-alpha) in normal, painful, and asymptomatic human dental pulps. METHODS:Pulps were obtained from three groups of teeth, including healthy teeth, asymptomatic teeth with caries and/or large restoration, and symptomatic teeth with clinical diagnosis of irreversible pulpitis. Pulpal tissues were collected, prepared, and analyzed for TNF-alpha concentration by ELISA technique. RESULTS:Nonparametric Kruskal-Wallis test revealed significant differences between TNF-alpha concentration in normal samples (64.01 +/- 53.12 pg/g) and irreversible symptomatic pulpal tissue (1962.99 +/- 1288.75 pg/g), between irreversible symptomatic and asymptomatic (1120.09 +/- 649.72 pg/g), and between normal and irreversible asymptomatic pulpal tissue (p = 0.000). CONCLUSIONS:TNF-alpha may be an objective marker for determining extent of pulpal inflammation associated with irreversible pulpitis.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Pezelj-Ribaric S,Anic I,Brekalo I,Miletic I,Hasan M,Simunovic-Soskic Mdoi
10.1016/s0188-4409(02)00396-xsubject
Has Abstractpub_date
2002-09-01 00:00:00pages
482-4issue
5eissn
0188-4409issn
1873-5487pii
S018844090200396Xjournal_volume
33pub_type
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journal_title:Archives of medical research
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doi:
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:
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