Inhibition of adhesion process mediated by anti-Entamoeba histolytica specific monoclonal IgA antibodies.

Abstract:

:Adhesion of trophozoites to target cells in the host intestine is the first of three consecutive steps (adherence, cytolytic effect and phagocytosis) involved in the invasion of colonic tissue by E. histolytica. To investigate the possible participation of the local secretory immune response in the interference with this early host-parasite relationship, we produced IgA monoclonal anti-E. histolytica antibodies to test their capacity for blocking the adhesion process in vitro (MDCK and HT-29 cell lines) and in situ (colonic mucosa from Balb/c mice and gerbils). Results demonstrate that the monoclonal antibodies tested inhibited trophozoite adherence both in vitro and in situ. This suggests that the local antibody response may play an important role in protection against the invasive process in intestinal amebiasis.

journal_name

Arch Med Res

authors

Leyva O,Rico G,Ramos F,Morán P,Melendro EI,Ximénez C

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

227-9

issue

2

eissn

0188-4409

issn

1873-5487

journal_volume

23

pub_type

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