Predictive value of creatine kinase (CK)-MB for diagnosis of acute myocardial infarction after major noncardiac surgery.

Abstract:

BACKGROUND:The aim of this study was to provide insight into the interpretation of CK-MB data after major noncardiac surgery. METHODS:Some 3,321 patients who underwent major non-emergent noncardiac procedures (orthopedic 31%, intrathoracic 12%, vascular 22%, other 35%) were studied. All patients had at least two CK samples measured postoperatively. RESULTS:Acute myocardial infarction was diagnosed in 43 (1.3%) patients using study criteria including CK-MB and electrocardiographic data. All of the various threshold values of peak CK-MB values and peak CK-MB as a percentage of total CK had poor positive predictive values because of high false positive rates and the low rate of acute myocardial infarction. CONCLUSION:These data demonstrate the need for markers of myocardial injury with greater cardiac specificity after noncardiac surgery.

journal_name

Arch Med Res

authors

López-Jiménez F,Goldman L,Thomas EJ,Kuntz KM,Sacks DB,Lee TH

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

33-7

issue

1

eissn

0188-4409

issn

1873-5487

journal_volume

29

pub_type

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