Abstract：
:Cardiovascular disease (CVD) is the leading cause of death in the world. According to the World Health Organization, an estimated 17.9 million people died from CVD in 2016, representing 31% of all global deaths. Of these deaths, 5% are due to myocardial infarction and stroke. Dyslipidemia is known as the major risk factor of atherosclerotic cardiovascular disease. With current therapies, about 60% of high-risk CVD patients do not achieve LDL-C goals, and in patients with familiar hypercholesterolemia (FH) at maximum intensity statin treatment, only 20% achieve LDL-C goals. We discuss new and future parenteral therapies for the management of lipid disorders.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Garcia R,Burkle Jdoi
10.1016/j.arcmed.2019.01.001subject
Has Abstractpub_date
2018-11-01 00:00:00pages
538-547issue
8eissn
0188-4409issn
1873-5487pii
S0188-4409(18)30822-1journal_volume
49pub_type
杂志文章,评审abstract：BACKGROUND:We tested the hypothesis that endurance over-training could alter the favorable effects of well-tolerated training on lipid profile. METHODS:At weeks 1, 6, 15, 26, 36, and 47 of the training program, blood was drawn to test lipid profile of 20 endurance-trained rowers. Diet and caloric intake were controlle...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2004.11.013
更新日期：2004-11-01 00:00:00
abstract：:In Mexico, hypercholesterolemia has become a major public health problem particularly in the states of the north of the country and in Mexico City, where a prevalence of 20% has been reported. Schemes of treatment have now been reinforced by the appearance of new cholesterol reducing drugs. The objective of the study ...
journal_title：Archives of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：BACKGROUND:Angiotensin converting enzyme (ACE) inhibitors and angiotensin II AT1-receptor antagonists prolong survival in experimental postischemic heart failure (CHF) in rats. The aim of this study was to investigate whether potential beneficial effects of early and long-term therapy with low doses of captopril or los...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/S0188-4409(03)00076-6
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND AND AIMS:HTLV-I-transformed T cells secrete biologically active forms of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF). In addition, HTLV-I-transformed cells have a high capacity of adhesion to endothelial cells. METHODS:We measured the circulating endothelial progenit...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2011.01.002
更新日期：2011-01-01 00:00:00
abstract：:Classical descriptions of the pathology of amebiasis portray the parasite as the cause of tissue damage and destruction, and in recent years a number of amebic molecules have been identified as virulence factors. In this review we describe a series of experiments that suggest a more complex host-parasite relation, at ...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2005.10.007
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Studies of breast cancer etiology suggest evidence that night shift working and occupational exposure to ionizing radiation (IR) are defined risk factors for breast cancer development. There are few studies to clarify neuroendocrine and inflammatory status and the possible consequences particularly in occupa...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.10.001
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Studies in platelet of 5-HT uptake transporters have been performed using binding assay methodology designed for ligand-receptor interactions; however, uptake transporters present requirements that may question the validity of these particular binding assays. METHODS:To explore methodologic aspects that may...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2003.03.001
更新日期：2003-09-01 00:00:00
abstract：:We report a study on the DNA organization in Entamoeba histolytica using a ribosomal DNA probe. The rDNA genes were found forming mers which were separated in a typical ladder pattern by pulse field electrophoresis. DNA rosette structures were visualized through electron microscopy in DNA eluted from bands recognized ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Distal renal tubular acidosis (dRTA) is characterized by a reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. Mutations in the SLC4A1 gene have been found to cause either autosomal dominant (AD) or autosomal recessive (AR)...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2012.05.001
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:High concentrations of interleukin-6 (IL-6) have been demonstrated in amniotic fluid (AF) from women with intra-amniotic infection. Recent studies have reported that IL-6 levels in AF were related to an increase in neonatal morbidity; moreover, higher IL-6 plasma levels have been observed in neonates with se...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-0128(99)00015-9
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND AND AIMS:An increasing number of studies have been published concerning meeting targets of clinical guidelines for different aspects of the diagnosis and treatment of patients with end-stage renal disease. Most of these studies have shown that guideline recommendations are not always satisfied, and results o...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2013.01.008
更新日期：2013-04-01 00:00:00
abstract：:A definitive single hypothesis about HIV pathogenesis is still lacking in specialized literature. Rather, a picture of the extreme complexity in AIDS causality ensues from the extensive information available. This article contains an outline of the most relevant data on the subject of AIDS pathogenesis, organized into...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1996-07-01 00:00:00
abstract：:Nicorandil, the first clinically applied ATP-sensitive K+ channel (K+ATP) opener with nitrate property, has demonstrated cardioprotective effects in patients with multiples of heart diseases. However, it is unknown whether nicorandil has effects on left ventricular (LV) remodeling in rats with ischemic heart failure a...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2018.12.006
更新日期：2018-11-01 00:00:00
abstract：:Implantation is a complex spatio-temporal interaction between the genotypically different embryo and the mother. Success of this event requires the synchronization of development and effective biochemical communications from both sides. Chorionic gonadotropin (CG), which is a major embryonic signal in the primate, is ...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/s0188-4409(01)00330-7
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:There is a need to assess whether human immunodeficiency virus (HIV)-infected patients are more likely than noninfected individuals to have any of the specific lipoprotein combination profiles identified as the best predictors of future cardiovascular disease in the general population. METHODS:One hundred f...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.06.012
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to determine whether newborn birth weights were associated with insulin-like growth factor I (IGF-I), zinc, and leptin in preeclamptic and normotensive pregnancies. METHODS:This study was done cross-sectionally and included 15 women with moderate preeclampsia (PE group) and ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(01)00364-2
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating IL-19 in acute ST-segment elevation myocardial infarction (STEMI) patients was detected....
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.01.007
更新日期：2020-02-01 00:00:00
abstract：:Thanks to the results of the multiple completed and ongoing genome sequencing projects and to the newly available recombination-based cloning techniques, it is now possible to build gene repositories with no precedent in their composition, formatting, and potential. This new type of gene repository is necessary to add...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/s0188-4409(02)00372-7
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Patients with certain types of stroke need urgent anticoagulation and it is extremely important for them to achieve fast and stable anticoagulant effect and receive individualized treatment during the initiation of warfarin therapy. METHODS:We conducted a prospective study among 210 acute stroke patients wh...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2015.05.001
更新日期：2015-05-01 00:00:00
abstract：:A prospective study to evaluate the role of vitamin C and cervico-vaginal infection in the premature rupture of amniotic membranes (PROM) was designed. The leukocyte vitamin C levels of 44 pregnant women that did not consume vitamin supplements was evaluated at weeks 20, 28 and 32 of pregnancy. On each evaluation the ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Exercise duration of constant-load endurance tests has been recently demonstrated to be more sensitive in detecting the changes after bronchodilator administration than either walking distance or peak oxygen uptake in patients with COPD. In the present study, we questioned whether exercise duration of progre...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.02.004
更新日期：2007-11-01 00:00:00
abstract：:Acute myeloid leukemia (AML) is a clonal disorder defined by the accumulation of abnormally differentiated myeloid cells that are not mature; any myeloid lineage can be affected and the extent of maturation of the leukemia blasts can also vary. Because mature blast cells of AML have very limited proliferative capacity...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2003.08.007
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:Because obesity masks the need for screening, there is no previous description of dyslipidemia in healthy normal-weight children. The aims of this study were a) to determine the prevalence of disorders in lipid profile among non-obese prepubertal children, and b) to establish its association with the family ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2006.06.003
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Previous published data have implicated TP53 codon 72 polymorphisms as risk factors for various cancers. Growing bodies of studies have been conducted on the association of TP53 codon 72 polymorphisms with susceptibility to oral carcinoma and have yielded inconclusive results. The aim of the present...
journal_title：Archives of medical research
pub_type： 杂志文章,meta分析
doi：10.1016/j.arcmed.2009.09.004
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:The aim of this study was to provide insight into the interpretation of CK-MB data after major noncardiac surgery. METHODS:Some 3,321 patients who underwent major non-emergent noncardiac procedures (orthopedic 31%, intrathoracic 12%, vascular 22%, other 35%) were studied. All patients had at least two CK sa...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:The diuretic response has been shown to be a robust independent marker of cardiovascular outcomes in acute heart failure (ADHF) patients. The objectives of this clinical research, will aim are to: a) include diuresis in the formula for diuretic response (R-to-D); b) add to R-to-D the value of a pre-discharge...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2018.08.007
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Metabolic acidosis (MA) is a frequent and serious complication in HIV-infected patients. The aim of the study is to compare patients with and without MA associated with HIV. METHODS:Patients were retrospectively studied involving all HIV-infected patients with blood gas analysis performed during ho...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2008.12.004
更新日期：2009-02-01 00:00:00
abstract：:Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outsid...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2014.11.010
更新日期：2014-11-01 00:00:00
abstract：:A matrix metalloproteinase with selective affinity for collagen was identified and partially purified from normal rat kidney. A two-step purification procedure consisting of gel filtration and affinity chromatography on Sepharose 4B-collagen resulted in an increase in specific activity of more than 3,000 times. The pa...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND AND AIMS:The pathogenesis of coronary artery ectasia (CE) is poorly understood. An underlying inflammatory process is suspected; current therapy aims to prevent thrombotic events. Presently, there is no evidence to support an anti-inflammatory approach for CE patients. We undertook this study to determine th...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2014.07.002
更新日期：2014-08-01 00:00:00
