Abstract:
BACKGROUND AND AIMS:The present study analyzed the relationship between TP53 codon 72 polymorphisms and the clinical outcome of advanced gastric cancer patients receiving capecitabine plus paclitaxel chemotherapy. METHODS:Three hundred patients with advanced gastric cancer treated with paclitaxel and capecitabine combination chemotherapy were enrolled in the present study. Genomic DNA was extracted from peripheral blood leukocytes and determined using allele specific polymerase chain reaction (AS-PCR). Correlation between TP53 codon 72 polymorphisms and treatment response, gastric cancer survival was analyzed. RESULTS:The Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to capecitabine plus paclitaxel chemotherapy in patients with gastric cancer when compared to the Arg/Arg genotype (30.6 vs. 63.2%, p value 0.000). Multivariate survival analysis also showed that the progression free survival (PFS) and overall survival (OS) for patients with Pro/Pro genotypes of TP53 codon 72 were worse than for those with the Arg/Arg genotype (hazard ratio [HR] = 2.177, p = 0.009; HR = 2.145, p = 0.038, respectively). CONCLUSIONS:TP53 codon 72 polymorphisms was effective in predicting the response to chemotherapy and correlate with PFS and OS in patients with advanced gastric cancer treated with paclitaxel and capecitabine chemotherapy.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Zha Y,Gan P,Liu Q,Yao Qdoi
10.1016/j.arcmed.2015.12.001subject
Has Abstractpub_date
2016-01-01 00:00:00pages
13-8issue
1eissn
0188-4409issn
1873-5487pii
S0188-4409(15)00285-4journal_volume
47pub_type
临床试验,杂志文章abstract:BACKGROUND:The aim of this study was to determine concentrations of tumor necrosis factor-alpha (TNF-alpha) in normal, painful, and asymptomatic human dental pulps. METHODS:Pulps were obtained from three groups of teeth, including healthy teeth, asymptomatic teeth with caries and/or large restoration, and symptomatic ...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(02)00396-x
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abstract::Nicorandil, the first clinically applied ATP-sensitive K+ channel (K+ATP) opener with nitrate property, has demonstrated cardioprotective effects in patients with multiples of heart diseases. However, it is unknown whether nicorandil has effects on left ventricular (LV) remodeling in rats with ischemic heart failure a...
journal_title:Archives of medical research
pub_type: 杂志文章
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abstract::Diabetes mellitus type II, a cause of preclinical left ventricular dysfunction that can progress to cardiac insufficiency ventricular dysfunction in diabetic patients, is attributed to systemic arterial hypertension, or ischemic cardiopathy. Diastolic ventricular dysfunction takes place during the course of diabetes m...
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abstract:OBJECTIVE:The aim of the study was to analyze, using a decision analysis approach, the probability of severity of illness due to delayed utilization of health services and inappropriate hospital medical treatment during the 2009 AH1N1 influenza epidemic in Mexico. METHODS:Patients with influenza AH1N1 confirmed by the...
journal_title:Archives of medical research
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abstract:BACKGROUND AND AIMS:The risks of insulin resistance and accelerated atherosclerosis are increased in chronic inflammatory diseases including rheumatoid arthritis (RA). Adipo-(cyto)kines are associated with insulin resistance, atherosclerosis and inflammation. This study aimed to determine serum adiponectin and vaspin l...
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abstract::Alzheimer's disease (AD) diagnosis still depends on the triad of clinical, imaging and neuropsychological testing. The development of accurate, easy to use and inexpensive biological markers for AD is a long-standing aspiration for researchers and the medical community. Here we describe some of the recent advances in ...
journal_title:Archives of medical research
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journal_title:Archives of medical research
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journal_title:Archives of medical research
pub_type: 杂志文章,评审
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2008.09.006
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2011.11.001
更新日期:2011-10-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Ultrafiltration, gel-sieve chromatography and HPLC were used to purify MLIF. This material was HCl-hydrolyzed and the amino acids analyzed by HPLC-ortho-ophthaldialdehyde. Two hydrophobic non-polar (ile,leu), two uncharged polar (thr,tyr) and two positively charged (basic) (his, arg) amino acids were found in clear ex...
journal_title:Archives of medical research
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doi:
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Studies in platelet of 5-HT uptake transporters have been performed using binding assay methodology designed for ligand-receptor interactions; however, uptake transporters present requirements that may question the validity of these particular binding assays. METHODS:To explore methodologic aspects that may...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2003.03.001
更新日期:2003-09-01 00:00:00
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journal_title:Archives of medical research
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doi:10.1016/j.arcmed.2020.06.013
更新日期:2020-10-01 00:00:00
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journal_title:Archives of medical research
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abstract:BACKGROUND AND AIMS:Jagged1/Notch3 signaling pathway plays a key role in angiogenesis of breast cancer, but little is known in TNBC. This study was designed to investigate the expression of Jagged1/Notch3 mRNA and protein in TNBC, analyze their correlations with clinicopathological characteristics and prognosis. Moreov...
journal_title:Archives of medical research
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journal_title:Archives of medical research
pub_type: 杂志文章,评审
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doi:10.1016/j.arcmed.2013.06.001
更新日期:2013-07-01 00:00:00
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更新日期:2005-09-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章,评审
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更新日期:2007-08-01 00:00:00
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更新日期:2019-10-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(02)00370-3
更新日期:2002-07-01 00:00:00
abstract::Intracellular communication is an essential process in both embryological development and for the maintenance of normal tissue physiology. We have established the presence of this type of communication between endothelial cells and vascular smooth muscle cells in man and have here investigated the close contacts betwe...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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更新日期:2007-11-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
abstract::The bioequivalence of three different commercial diazepam tablets (5 mg) using the innovator product (Valium, Roche) as a reference was evaluated in eight psychiatric patients, following a multiple-dose regimen (5 mg t.i.d.). Each patient received the four treatments sequentially according to a Latin square design, wi...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:
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