Abstract:
:Genetic alterations in tumors, as predictor of response to targeted-therapies or as prognostic markers, are clinically relevant to determine adequate therapeutic management. Tumor biopsy is currently the golden standard for somatic alterations assessment, but this approach is invasive and does not consider tumor heterogeneity. In various body fluids like plasma, somatic mutations have been identified. Circulating tumor DNA (ctDNA) holds promises in tumor burden monitoring or malignancies early detection. Since allele frequencies of circulating somatic mutations are low, highly sensitive novel assays have been developed to allow the investigation of the tumor genome, leading to the emergence of the "liquid biopsy" concept. Despite these technological advances, other assays for identifying intratumor and intermetastases heterogeneity need to be developed. Before being applied to clinic, ctDNA analyses need to be harmonized and validated with well-powered, well-designed studies. One of the primary prerequisite to incorporation of ctDNA analysis in the follow-up strategy of malignancies is the checking of the concordance with golden standard detection methods, imaging, circulating proteins and biopsy. This review focuses on the clinical interest of ctDNA in solid tumors and hematological malignancies.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Franczak C,Filhine-Tressarieu P,Broséus J,Gilson P,Merlin JL,Harlé Adoi
10.1016/j.arcmed.2018.10.007subject
Has Abstractpub_date
2018-07-01 00:00:00pages
297-305issue
5eissn
0188-4409issn
1873-5487pii
S0188-4409(18)30389-8journal_volume
49pub_type
杂志文章,评审abstract::Global warming has serious implications for all aspects of human life, including infectious diseases. The effect of global warming depends on the complex interaction between the human host population and the causative infectious agent. From the human standpoint, changes in the environment may trigger human migration, ...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
doi:10.1016/j.arcmed.2005.03.041
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Patients suffering from hypothyroidism tend to develop diastolic hypertension. 5-Hydroxytryptamine (5-HT) is an amine that contributes to the maintenance of the blood pressure through central and peripheral 5-HT receptors. Curiously, the hypothyroidism alters the density of the 5-HT receptors in rodent brain...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2020.03.013
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Preimplantation genetic diagnosis (PGD) of monogenic autosomal hereditary disorders following assisted conception usually involves the removal of one or two blastomeres from preimplantation embryos. However, the amount of DNA from a single blastomere is insufficient to amplify the region of interest. Hence, ...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2008.10.008
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND AIM:Oxalobacter formigenes is an intestinal bacterium that utilizes oxalate as the only source of energy. It has been suggested that the lack of colonization with this organism may be a risk factor for calcium oxalate urolithiasis. Because this problem was not investigated in pediatric stone formers, we ...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2009.05.004
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Recently, the Expert Committee of the American Diabetes Association proposed to decrease the lower limit for normal fasting plasma glucose (FPG) levels to 5.6 mmol/L. In this regard, the aim of this study was to determine the effect of lowering the criterion for normal FPG on the identification of subjects w...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2005.05.010
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive oxygen radical species are involved with the pathophysiology of cisplatin-induced hepatotoxicity. Molsidomine (MOL) can exert antioxidant an...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2013.09.013
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Lung adenocarcinoma (LAC) is a major worldwide cause of death by cancer, it shows high aggressiveness, functional decline, systemic compromise and severe cachexia, which might be counteracted by dietary redox-active phytochemicals. Therefore, our aim was to establish the anticancer effects of the oral intake...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2019.11.006
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Few studies have described the association between hepcidin levels and cardiometabolic risk in the general population and more so by considering robust adjustment for confounding factors. Therefore, the aim of the present study was to investigate the associations between circulating hepcidin and ant...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2015.07.007
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Although the role of cytokines in the development of Hashimoto's thyroiditis has already been established, its pathogenesis has not yet been clearly elucidated. The aim of our study was to investigate serum transforming growth factor-beta1 (TGF-beta1) levels in patients with Hashimoto's thyroiditis as well a...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2007.12.001
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND AND AIMS:MicroRNA-34a (miR-34a) as a tumor suppressor has been reported in many other studies. However, its role in modulating the sensitivity of breast cancer cells to adriamycin (ADR) remains unclear. The aim of this study is to evaluate the role of miR-34a in the sensitivity of breast cancer cells to ADR....
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2012.09.007
更新日期:2012-10-01 00:00:00
abstract::Classical descriptions of the pathology of amebiasis portray the parasite as the cause of tissue damage and destruction, and in recent years a number of amebic molecules have been identified as virulence factors. In this review we describe a series of experiments that suggest a more complex host-parasite relation, at ...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
doi:10.1016/j.arcmed.2005.10.007
更新日期:2006-02-01 00:00:00
abstract::The objective of this study was to compare two methods for the extraction of high motility sperm; washed semen and swim-up techniques, on 172 ejaculates from 53 patients with suspected infertility. High quality motile sperm had been essential for the success of the assisted reproductive procedures, in which these pati...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Previous studies demonstrated that (99m)Tc-labeled-ubiquicidin 29-41 ((99m)Tc-UBI 29-41) imaging is an accurate method for detection of bacterial infections. This study was conducted to evaluate the clinical use of (99m)Tc-UBI 29-41 for detection of mediastinitis after cardiac surgery. METHODS:Thirteen pati...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2008.09.002
更新日期:2008-11-01 00:00:00
abstract::A matrix metalloproteinase with selective affinity for collagen was identified and partially purified from normal rat kidney. A two-step purification procedure consisting of gel filtration and affinity chromatography on Sepharose 4B-collagen resulted in an increase in specific activity of more than 3,000 times. The pa...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Animal experiments showed that interaction between advanced glycation end products (AGE) and their receptors (RAGE) play an important role in the pathogenesis of diabetic complications. Soluble RAGE (sRAGE) can function as a decoy for RAGE ligands. The present study aimed to examine the levels of AG...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2011.11.001
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:A comprehensive understanding of the immune response induced by Mycobacterium bovis Bacille Calmette-Guérin in activation of protective T cells against tuberculosis is important to develop effective therapies to combat this disease. In this study, our experiments were designed to determine effects of transfo...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(02)00463-0
更新日期:2003-01-01 00:00:00
abstract::To determine the effects of a vegetarian diet with avocado as a source of monounsaturated fat on serum lipids, thirteen patients with phenotype II (twelve with IIa and one with IIb) dyslipidemia were included in a prospective, transversal and comparative study in which three four-week diets randomly assigned were asse...
journal_title:Archives of medical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Because obesity masks the need for screening, there is no previous description of dyslipidemia in healthy normal-weight children. The aims of this study were a) to determine the prevalence of disorders in lipid profile among non-obese prepubertal children, and b) to establish its association with the family ...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2006.06.003
更新日期:2006-11-01 00:00:00
abstract::During the past few years, an increasing set of evidence has supported the major role of deregulation of the interaction patterns between glial cells and neurons in the pathway toward neuronal degeneration. Neurons and glial cells, together with brain vessels, constitute an integrated system for brain function. Inflam...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
doi:10.1016/j.arcmed.2007.10.001
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Myocardial infarction (MI) is one of the most important diseases that has stimulated interest in understanding cardiac function recovery. SDF-1 is a chemotactic factor and a pro-angiogenic molecule; SDF-1 degradation is inhibited by dipeptidyl peptidase-4 (DPP4) inhibitors, such as vildagliptin. We investiga...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2019.07.004
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) has been shown to improve the clinical status and survival in congestive heart failure (CHF) patients, but little is known about its influence on neurohormonal profile. METHODS:Heart failure patients treated with CRT for moderate/severe heart failure were studied with...
journal_title:Archives of medical research
pub_type: 临床试验,杂志文章
doi:10.1016/j.arcmed.2008.07.004
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND AND AIMS:This study was designed to identify susceptibility to insulin resistance and the association of serum resistin and adiponectin with insulin resistance in patients with Behçet's disease (BD). Also, we identify risk determinants for insulin resistance in BD patients. METHODS:The study population cons...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2010.05.008
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Polymorphisms which are inherited alterations in the activity of cytochrome P450 1B1 (CYP1B1), catechol O-methyltransferase (COMT), manganese superoxide dismutase (MnSOD) hold the potential to define differences in estrogen metabolism and, thereby, possibly explain inter-individual differences in cancer susc...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2004.10.003
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Streptococcus pneumoniae constitutes one of the main causes of sepsis, bacteremia and meningitis (pneumococcal invasive disease - PID), and pneumonia in infants and small children. Antipneumococcal vaccination in Mexico is expected to be a useful strategy to reduce morbimortality due to this cause. ...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2012.12.005
更新日期:2013-02-01 00:00:00
abstract::Two hundred fifty women with hirsutism were studied, with a mean age of 25.5 years (ranging from 13 to 38 years). The evolution of hirsutism varied from 3 months to 13 years, being minimal in 82 patients (33%), mild to 101 (40%), moderate in 56 (23%) and severe in the remaining 11 women (4%). Polycystic ovary syndrome...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating IL-19 in acute ST-segment elevation myocardial infarction (STEMI) patients was detected....
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2020.01.007
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:The diuretic response has been shown to be a robust independent marker of cardiovascular outcomes in acute heart failure (ADHF) patients. The objectives of this clinical research, will aim are to: a) include diuresis in the formula for diuretic response (R-to-D); b) add to R-to-D the value of a pre-discharge...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2018.08.007
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Psychiatrists may be at an increased risk of suicide, since they encounter stressful factors in their everyday activities in addition to the sociodemographic factors for suicidal ideation reported for Mexican population. AIM OF THE STUDY:To determine whether experiences inherent to the profession were relat...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2019.11.010
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Supplementation with n3 long-chain polyunsaturated fatty acids (n3-LCPUFA) appears to affect body weight, adipokines, and insulin resistance (IR) in obese individuals. However, it is unclear whether the effect on IR is independent of weight loss and if the same effect is observed in children. We und...
journal_title:Archives of medical research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.arcmed.2011.06.010
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND AND AIMS:We undertook this study to investigate the association between CT perfusion characteristics and differentiation grade in lung cancer, as well as the pathological basis of this association. METHODS:Seventy three patients received CT perfusion scan and pathological biopsy, and 30 of them were availab...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2010.11.005
更新日期:2010-11-01 00:00:00