Assessment of Aortic Stiffness in Patients with Rheumatoid Arthritis Using Pulse Wave Velocity: An Update Meta-analysis.

Abstract:

BACKGROUNDS:Rheumatoid arthritis (RA) is a systemic autoimmune disease that confers one of the strongest risks for cardiovascular disease (CVD) morbidity and mortality than in general population. Pulse wave velocity (PWV) and augmentation index (AIx) are composite measures of arterial stiffness (AS) and associated with CV risk. AIM OF THE STUDY:The aim of this study was to systemically review the evidence regarding the relationship between PWV, AIx and RA, as well as underlying influential factors. METHODS:Eligible literatures were searched in PubMed, EMBASE and The Cochrane Library published up to February 28, 2019 in English. The pooled weight mean difference (WMD) with its 95% confidence interval (CI) was calculated using random-effect model analysis. RESULTS:A total of 38 studies were finally incorporated in the meta-analysis. The results indicated that, compared to controls, RA patients had significantly increased levels of carotid-femoral (cf)-PWV (WMD = 1.10 m/s, 95% CI: 0.84-1.35), brachial-ankle (ba)-PWV (WMD = 0.20 m/s, 95% CI: 0.12-0.28), cartoid-radial (cr)-PWV (WMD = 0.51 m/s, 95% CI: 0.23-0.79), AIx (WMD = 4.79%, 95% CI: 1.34-8.24) and AIx normalized to a 75 beats/minute heart rate (AIx@75) (WMD = 5.78%, 95% CI: 3.82-7.74) (all p <0.001). Meta-regression and subgroup analysis demonstrated significant association of cf-PWV with age, disease duration and erythrocyte sedimentation rate (ESR) in RA. CONCLUSIONS:Overall, there is increased PWV level in patients with RA, and this alteration is associated with age, disease duration and ESR.

journal_name

Arch Med Res

authors

Wang P,Huang L,Xu Q,Xu L,Deng FY,Lei SF

doi

10.1016/j.arcmed.2019.10.010

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

401-412

issue

7

eissn

0188-4409

issn

1873-5487

pii

S0188-4409(19)30351-0

journal_volume

50

pub_type

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