Cardiovascular Responses to 5-hydroxytryptamine in Methimazole-induced Hypothyroid Pithed Rats.

Abstract:

BACKGROUND:Patients suffering from hypothyroidism tend to develop diastolic hypertension. 5-Hydroxytryptamine (5-HT) is an amine that contributes to the maintenance of the blood pressure through central and peripheral 5-HT receptors. Curiously, the hypothyroidism alters the density of the 5-HT receptors in rodent brains. AIM OF THE STUDY:Analyze the effect of the methimazole-induced hypothyroidism on the peripheral cardiovascular responses elicited by 5-HT. METHODS:The vasopressor and tachycardic responses to 5-HT (3-300 μg/kg), and the vasodepressor responses to 5-HT, 5-carboxamidotryptamine (5-CT, 0.001-0.1 μg/kg), isoprenaline (0.03-1 μg/kg) and acetylcholine (ACh, 0.03-3 μg/kg), during an infusion of methoxamine, were determined in pithed hypothyroid rats. RESULTS:The tachycardic and vasopressor responses to 5-HT and the vasodepressor responses to 5-CT and ACh remained unaffected, the vasodepressor response to 5-HT reduced, and the vasodepressor response to isoprenaline enhanced and reduced at the lowest and highest dose, respectively. CONCLUSION:These results suggest that hypothyroidism impairs the vasodepressor response to 5-HT, which could contribute to hypothyroidism-induced hypertension.

journal_name

Arch Med Res

authors

Cobos-Puc L,Urbina-Ruiz P,Pacheco-Rosado J,Aguayo-Morales H,Sánchez-López A,Centurión D

doi

10.1016/j.arcmed.2020.03.013

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

310-316

issue

4

eissn

0188-4409

issn

1873-5487

pii

S0188-4409(19)30685-X

journal_volume

51

pub_type

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