Abstract：
BACKGROUND:Quinolone-induced mutagenesis in the Salmonella typhimurium hisG48 strains suggests that these antibiotics are oxygen free radical generators. The use of beta-carotene as antioxidant was evaluated as an alternative to reduce oxidative cell damage in patients who need therapy with nalidixic acid, norfloxacin, or pipemidic acid. The studied beta-carotene (30%), used by pharmaceutical laboratories as dietary complements, was not toxic or mutagenic for the S. typhimurium TA102 strain at a dose equivalent to 1,500 I.U. At the studied concentrations, the evaluated antimutagen did not modify the minimum inhibitory concentration of nalidixic acid, norfloxacin, or pipemidic acid against uropathogenic Escherichia coli strains. METHODS:The mutagenic effect of nalidixic acid and norfloxacin against hisG48 strains was inhibited with 1500 I.U. of beta-carotene. The antimutagenic effect of beta-carotene against mutations induced by pipemidic acid was observed even with 150 I.U. of beta-carotene. The antimutagenic effect against mutations induced on S. typhimurium TA102 or TA104 strains was observed only when the aroclor 1254 rat-induced liver S9 mixture was used. RESULTS:This mutagenic effect was detected only when the strains were exposed to quinolones and the beta-carotene simultaneously with the S9 mixture, suggesting that quinolones induce oxygen free radicals that may be scavenged by beta-carotene. CONCLUSIONS:The antimutagenic effect of this vitamin A precursor is probably due to the active molecule of vitamin A, a desmutagen with the ability of radical capture. A diet rich in beta-carotene or vitamin A could be a good alternative to reduce genotoxic risk to patients being treated with quinolone.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Arriaga-Alba M,Rivera-Sánchez R,Parra-Cervantes G,Barro-Moreno F,Flores-Paz R,García-Jiménez Edoi
10.1016/s0188-4409(00)00046-1subject
Has Abstractpub_date
2000-03-01 00:00:00pages
156-61issue
2eissn
0188-4409issn
1873-5487pii
S0188-4409(00)00046-1journal_volume
31pub_type
杂志文章abstract：:Hué, a city of about 300,000 inhabitants in Central Vietnam, is known as a "hot spot" for diseases caused by Entamoeba histolytica and in particular for amebic liver abscess (ALA), thus representing an excellent site for studies on the epidemiology and treatment of E. histolytica infections. Accordingly, during the la...
journal_title：Archives of medical research
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journal_title：Archives of medical research
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pub_type： 杂志文章
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journal_title：Archives of medical research
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更新日期：1993-07-01 00:00:00
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journal_title：Archives of medical research
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journal_title：Archives of medical research
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更新日期：1996-10-01 00:00:00
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journal_title：Archives of medical research
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更新日期：2011-02-01 00:00:00
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journal_title：Archives of medical research
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更新日期：1994-10-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章,meta分析
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更新日期：2009-10-01 00:00:00
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更新日期：2003-07-01 00:00:00
