Abstract：
BACKGROUND AND AIMS:Metabolic acidosis (MA) is a frequent and serious complication in HIV-infected patients. The aim of the study is to compare patients with and without MA associated with HIV. METHODS:Patients were retrospectively studied involving all HIV-infected patients with blood gas analysis performed during hospital stay admitted to a single hospital between April 2004 and July 2006. Statistical analysis was performed using SPSS 10.0 for Windows. RESULTS:Included in the study were 159 HIV patients, 72 cases (45.3%) with MA and 87 cases (54.7%) without. The comparison of both groups showed a mean arterial pH of 7.24 +/- 0.08 vs. 7.44 +/- 0.05, HCO(3) 12 +/- 5.7 vs. 21 +/- 5.1 mEq/L, serum urea 81 +/- 68 mg/dL vs. 39 +/- 46 mg/dL and serum creatinine 2.7 +/- 2.6 mg/dL vs. 1.2 +/- 1.9 mg/dL in MA-HIV and non-MA-HIV, respectively (p <0.05). Antiretroviral therapy (ART) was being administered to 38 subjects (52.8%) in MA-HIV group and 45 (51.7%) in non-MA-HIV group (p = 0.57). There was no association between the use of ART and MA. Mortality was higher in patients with acidosis (52.7 vs. 17.2%, p <0.0001). CONCLUSIONS:In the present study, MA was associated with acute kidney injury and increased mortality. There was no association between the use of ART and MA.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Daher EF,Cezar LC,Silva GB Jr,Lima RS,Damasceno LS,Lopes EB,Nunes FR,Mota RS,Libório ABdoi
10.1016/j.arcmed.2008.12.004subject
Has Abstractpub_date
2009-02-01 00:00:00pages
109-13issue
2eissn
0188-4409issn
1873-5487pii
S0188-4409(08)00301-9journal_volume
40pub_type
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