Abstract：
:At the end of the year 2019, the novel coronavirus (2019-nCoV) was spreading in Wuhan, China, and the outbreak process has a high speed. It was recognized as a pandemic by the World Health Organization (WHO) on 11 March 2020. Coronaviruses are enveloped and single-stranded RNA that have several families including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The pathogenesis mechanism and disease outcomes of SARS and MERS are now clear to some extent, but little information is available for 2019-nCoV. This newly identified corona virus infection represents flu-like symptoms, but usually the first symptoms are fever and dry cough. There has been no specific treatment against 2019-nCoV up to now, and physicians only apply supportive therapy. In the present article, we made an attempt to review the behavior of the virus around the world, epidemiology, a pathway for influx into the host cells, clinical presentation, as well as the treatments currently in use and future approaches; nitazoxanide may be our dream drug. We hope that this review has a positive impact on public knowledge for helping to deal with the 2019-nCoV and move one step forward toward its treatment in the near future.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Hemmati F,Saedi S,Hemmati-Dinarvand M,Zarei M,Seghatoleslam Adoi
10.1016/j.arcmed.2020.04.022subject
Has Abstractpub_date
2020-07-01 00:00:00pages
375-383issue
5eissn
0188-4409issn
1873-5487pii
S0188-4409(20)30550-6journal_volume
51pub_type
杂志文章,评审abstract：BACKGROUND:Exercise duration of constant-load endurance tests has been recently demonstrated to be more sensitive in detecting the changes after bronchodilator administration than either walking distance or peak oxygen uptake in patients with COPD. In the present study, we questioned whether exercise duration of progre...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.02.004
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:A recent revelation about increased susceptibility to HIV by use of nonoxynol-9 (N-9) has called for identification of novel molecules with potent sperm-attenuating activity and lower side-effect profile, as suitable alternatives. The present study was designed to investigate spermicidal activity in Bohadsch...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2008.06.007
更新日期：2008-10-01 00:00:00
abstract：OBJECT:Astragaloside IV (AS IV) has antioxidative and anti-apoptotic properties, however, its effects on juvenile mice with diabetic ketoacidosis (DKA) have not been determined. This study aims to explore the effect and mechanism of Astragaloside IV (AS-IV) on juvenile mice with DKA. METHODS:DKA model was established ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.06.013
更新日期：2020-10-01 00:00:00
abstract：:Glutamate neurotransmitter action on postsynaptic receptors is terminated by its clearance from the synaptic cleft by transporter proteins located in neurons and glial cells. Failure of glutamate removal can lead to neuronal death due to its well-known neurotoxic properties. Glutamate transporters are dependent on ext...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2005.05.014
更新日期：2006-01-01 00:00:00
abstract：:Alzheimer's disease (AD) diagnosis still depends on the triad of clinical, imaging and neuropsychological testing. The development of accurate, easy to use and inexpensive biological markers for AD is a long-standing aspiration for researchers and the medical community. Here we describe some of the recent advances in ...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2012.10.013
更新日期：2012-11-01 00:00:00
abstract：:In this report we show the chromosomal changes seen in a group of 303 Mexican patients with de novo Acute Myeloblastic Leukemia (AML). Two hundred forty-two patients were diagnosed and treated at two hospitals affiliated with the Instituto Mexicano del Seguro Social (IMSS). These are the Centro Medico Nacional Siglo X...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:The frequency of neurologic manifestations of the central nervous system (CNS) as a defining disease of acquired immunodeficiency syndrome (AIDS) (neurologic manifestation defining disease [NMDD-AIDS]) varies according to geographic region. The aim of this study was to determine its prevalence among patients...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2003.07.004
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:This study investigated the association of working conditions and lifestyle with the development of increased serum gamma-glutamyltransferase (GGT) in Japanese workers. METHODS:A follow-up study was carried out on workers of a telecommunication enterprise who received their first annual health check-up betw...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.03.027
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Osteoporosis (OP) and its fractures are a major problem due to their impact in morbidity and mortality in the elderly. Although this entity is well studied in other countries, OP and its fractures have not been evaluated carefully in our population. The objective was to assess risk factors for osteoporotic h...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:Chromosomal abnormalities have important diagnostic and prognostic significance in acute lymphoblastic leukemia (ALL). The purpose of this study was to define and classify the frequency and type of chromosomal abnormalities among newly diagnosed children with ALL and compare the results with those reported f...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2006.10.006
更新日期：2007-04-01 00:00:00
abstract：:Cholelithiasis is one of the most prevalent gastroenterological diseases, precipitated mainly by environmental factors. However, twin studies provided strong evidence for a role of genetic factors in the disease pathogenesis. An association between plasma lipoprotein levels and gallstone disease (GSD) was presented. A...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2006.11.003
更新日期：2007-04-01 00:00:00
abstract：:Policosanol, a defined mixture of high molecular weight aliphatic alcohol isolated and purified from sugar cane (Saccharum officinarum, L) wax is a new cholesterol-lowering agent effective in experimental models, healthy volunteers, and patients with type II hypercholesterolemia. Also, policosanol prevents the onset o...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:The bioequivalence of three different commercial diazepam tablets (5 mg) using the innovator product (Valium, Roche) as a reference was evaluated in eight psychiatric patients, following a multiple-dose regimen (5 mg t.i.d.). Each patient received the four treatments sequentially according to a Latin square design, wi...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND:Preimplantation genetic diagnosis (PGD) of monogenic autosomal hereditary disorders following assisted conception usually involves the removal of one or two blastomeres from preimplantation embryos. However, the amount of DNA from a single blastomere is insufficient to amplify the region of interest. Hence, ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2008.10.008
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Little is known about the potential relationship of obesity, adipose tissue and novel adipokines with cardiometabolic risk factors in end-stage renal disease. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with proposed desirable effects on inflammation, and lipid and ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2017.10.004
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The main objectives in this work were to determine whether the relationship between serum testosterone concentration and electroencephalography (EEG) develop mental change observed in human males is also present in Macaca mulatta and, if so, to determine which frequency bands are involved and which regions c...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2004.06.003
更新日期：2004-09-01 00:00:00
abstract：:We report a study on the DNA organization in Entamoeba histolytica using a ribosomal DNA probe. The rDNA genes were found forming mers which were separated in a typical ladder pattern by pulse field electrophoresis. DNA rosette structures were visualized through electron microscopy in DNA eluted from bands recognized ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND:Metabolic syndrome (MetS) is a heterogeneous clinical entity associated with insulin resistance, low-grade proinflammatory balance and impaired endothelial function, accelerating atherosclerosis. Atherosclerotic lesions worsen with age, smoking and co-morbidities, making it difficult to accurately diagnose t...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2019.05.003
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND AND AIMS:This study was carried out to assess and investigate the prevalence of overweight and obesity among preschool-age children living in northeast China using the World Health Organization (WHO), International Obesity Task Force (IOTF) and Centers for Disease Control and Prevention (CDC) standard criter...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2011.10.011
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:We undertook this study to analyze serum and platelet gamma-glutamyltransferase (GGT) activity and total antioxidant status (TAS) concentration during the course of pneumonia and to compare them between patients with normal platelet count and those who developed reactive thrombocytosis. METHODS:Platelet cou...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.01.005
更新日期：2007-05-01 00:00:00
abstract：:In Mexico, hypercholesterolemia has become a major public health problem particularly in the states of the north of the country and in Mexico City, where a prevalence of 20% has been reported. Schemes of treatment have now been reinforced by the appearance of new cholesterol reducing drugs. The objective of the study ...
journal_title：Archives of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：BACKGROUND AND AIMS:To compare the prevalence of lactose malabsorption (LM) in children by analyzing hydrogen content in expired air vs. the inclusion of methane excretion. METHODS:A total of 138 children (4-17 years old) attending different boarding schools in Mexico were included in this study. To measure H₂ and CH₄...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2013.04.005
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:During congestive heart failure, desensitization of beta-adrenoceptors is related to a lower adrenergic responsiveness in the heart; little is known about alpha 1-adrenoceptors in the vasculature under this condition. We evaluated alpha 1D-adrenoceptor response in aorta and carotid arteries in a model of con...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-0128(99)00033-0
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND AND AIMS:Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive oxygen radical species are involved with the pathophysiology of cisplatin-induced hepatotoxicity. Molsidomine (MOL) can exert antioxidant an...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2013.09.013
更新日期：2013-10-01 00:00:00
abstract：:Chronic cerebellar stimulation (CCS) applied to the superio-medial cortex reduces generalized cerebral spasticity, athetoid movements, and seizures. Eighteen clinics have reported on 600 cerebral palsy (CP) patients who comprise 90% of those treated with CCS. CP patients have varying degrees of limited abilities inter...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/s0188-4409(00)00065-5
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Estrogens exert profound effects on target tissues. These effects are mediated by two estrogen receptors (ER(alpha) and ER(beta)) that bind to specific DNA sequences in estrogen-dependent genes. Other molecules such as growth factors, transcription factors and some oncoproteins might interact with the estrog...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.03.030
更新日期：2005-07-01 00:00:00
abstract：:Corneal neovascularization is a significant, sight-threatening complication of many ocular surface disorders. Various growth factors and proteinases are involved in corneal neovascularization. The data supporting a causal role for vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are exten...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2007.04.006
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Bisalbuminemia is a dysproteinemia characterized by the occurrence of two albumin fractions on serum protein separation by electrophoresis on cellulose acetate sheets. Bisalbuminemia may occur as a hereditary trait or as analytical interference with some drugs, especially penicillin. METHODS:Two patients wi...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(00)00251-4
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Recently, the Expert Committee of the American Diabetes Association proposed to decrease the lower limit for normal fasting plasma glucose (FPG) levels to 5.6 mmol/L. In this regard, the aim of this study was to determine the effect of lowering the criterion for normal FPG on the identification of subjects w...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.05.010
更新日期：2006-01-01 00:00:00
abstract：:The effect of electric field stimulation for promoting axonal growth between sural to facial nerve grafts in cases of congenital permanent facial palsy associated with hemifacial microsomia was studied. For this purpose, a total of 17 patients with unilateral congenital permanent facial palsy associated with hemifacia...
journal_title：Archives of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-04-01 00:00:00
