Abstract：
BACKGROUND AND AIMS:Phosphodiesterases 5 and 9 (PDE5, PDE9) are enzymes responsible for regulating second messenger signaling by hydrolyzing 3',5' cyclic guanosine monophosphate (cGMP). PDE isoforms are deregulated in some types of human cancer. The present study was carried out to evaluate the expression of phosphodiesterase isoenzymes, PDE5 and PDE9, in benign and malignant breast tumors. METHODS:The expression levels of PDE5 and PDE9 were assayed in malignant and benign breast tumors and corresponding normal breast tissues using quantitative real-time RT-PCR. Moreover, the correlation between PDE5, PDE9 relative expression and clinicopathological characteristics were analyzed. RESULTS:The relative expressions of PDE5 and PDE9 in malignant tumors were significantly higher than those of respective normal breast tissues and benign tumors (5.5-fold, p <0.001 and 6-fold, p <0.001, respectively). Furthermore, a significant positive correlation was found between PDE5 and PDE9 overexpression and tumor grade, stage, and lymph node involvement. However, a negative correlation was observed with age. CONCLUSIONS:Based on the present results, it is concluded that assessment of PDE5 and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer. To the best of our knowledge, this is the first study to show that PDE5 and PDE9 expression levels are higher in malignant breast tumors than those of normal and benign breast tissue.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Karami-Tehrani F,Moeinifard M,Aghaei M,Atri Mdoi
10.1016/j.arcmed.2012.08.006subject
Has Abstractpub_date
2012-08-01 00:00:00pages
470-5issue
6eissn
0188-4409issn
1873-5487pii
S0188-4409(12)00209-3journal_volume
43pub_type
杂志文章abstract：:COVID-19 is a devastating global pandemic around the world. While the majority of infected cases appear mild, in some cases individuals present respiratory complications with possible serious lung damage. There are no specific treatments for COVID-19 as yet, though a number are under evaluation, including experimental...
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pub_type： 杂志文章,评审
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abstract：BACKGROUND:The benefits of a special stroke care unit (SSCU) over a non-specialized stroke care unit (NSSCU) is well documented in the literature. However, there are concerns that the benefits seen in the SSCU do not consider clinical risk factors that affect thrombolysis therapy. METHOD:Retrospective data were collec...
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journal_title：Archives of medical research
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journal_title：Archives of medical research
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pub_type： 临床试验,杂志文章
doi：
更新日期：1996-07-01 00:00:00
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更新日期：1997-07-01 00:00:00
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journal_title：Archives of medical research
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journal_title：Archives of medical research
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