Abstract:
BACKGROUND AND AIMS:Small cell lung cancer (SCLC) is frequently associated with syndrome of inappropriate antidiuretic hormone (SIADH) secretion. In this study we investigated the prognostic value of SIADH in Chinese patients with SCLC. METHODS:We prospectively studied a total of 385 patients with SCLC diagnosed in our institution. The relationship between the SIADH and treatment outcomes including progression-free survival (PFS) and overall survival (OS) were analyzed. Univariate analysis and Cox multivariate analyses were used for statistical analyses. PFS and OS curves were drawn using Kaplan-Meier method. RESULTS:The median PFS and OS in patients with SIADH was 6.7 months (95% confidence interval [CI]: 4.3-9.1) and 11.6 months (95% CI: 7.4-15.7), respectively. The corresponding PFS and OS in SCLC without SIADH was 9.2 months (95% CI: 8.6-9.8) and 19.2 months (95% CI: 16.5-21.9), respectively; the difference between groups was statistically significant (p = 0.007 and p = 0.000, respectively). The association of SIADH with poor PFS (p = 0.000) and OS (p = 0.002) retained its statistical significance after adjusting for potential confounding variables. In addition, PFS (p = 0.000) and OS (p = 0.000) of SIAHD patients with plasma sodium <125 mmol/L or without plasma sodium recovery to normal level are both shorter than in patients without SIADH. OS in SIAHD patients with plasma sodium recovery time to normal level is also shorter than patients without SIADH (p = 0.03). CONCLUSIONS:SIADH is a common occurrence in patients with SCLC and is associated with poor prognosis for SCLC in Chinese patients.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Wang X,Liu M,Zhang L,Ma Kdoi
10.1016/j.arcmed.2015.12.006subject
Has Abstractpub_date
2016-01-01 00:00:00pages
19-24issue
1eissn
0188-4409issn
1873-5487pii
S0188-4409(15)00290-8journal_volume
47pub_type
杂志文章abstract:BACKGROUND:Coronary artery disease is the significant cause of morbidity and mortality today. The treatment of coronary artery disease is improving, but its prevalence is increasing. Both primary and secondary prevention measures are of vital importance. METHODS:In this study, vitamin C, total antioxidant status, malo...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(01)00381-2
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abstract::The pathological sequence for type 2 diabetes is complex and entails many different elements that act in concert to cause that disease. This review proposes a sequence of events and how they interact by a careful analysis of the human and animal model literature. A genetic predisposition must exist, although to date v...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
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journal_title:Archives of medical research
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更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.arcmed.2008.06.007
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journal_title:Archives of medical research
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更新日期:2016-08-01 00:00:00
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更新日期:2011-01-01 00:00:00
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更新日期:2019-10-01 00:00:00
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journal_title:Archives of medical research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-09-01 00:00:00
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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更新日期:2013-08-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章,meta分析
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更新日期:2009-05-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
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