Paradoxic response to diazepam in complex partial status epilepticus.

Abstract:

BACKGROUND:Antiepileptics including benzodiazepines have long been recognized to provoke seizures and precipitate status epilepticus occasionally. This has a special clinical importance in the case of diazepam because of its use as first choice medication in its management. This report is intended to highlight the clinical importance of such a situation. METHODS:The clinical course of a 28-year old man with complex partial status, which lasted for two months, is described in detail. RESULTS:Paradoxic response to diazepam was documented under EEG monitoring. A similar response was also noted for midazolam, and had probably contributed in exacerbating and prolonging the duration of status. CONCLUSION:Paradoxic response to diazepam and midazolam is rare, but may be under-recognized. It should be considered in the setting of refractory status epilepticus.

journal_name

Arch Med Res

authors

Al Tahan A

doi

10.1016/s0188-4409(00)00043-6

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

101-4

issue

1

eissn

0188-4409

issn

1873-5487

pii

S0188-4409(00)00043-6

journal_volume

31

pub_type

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