Abstract：
BACKGROUND:Selenoproteins S (SELS or VIMP) may regulate cytokine production, and thus play a key role in the control of the inflammatory response. METHODS:This study consisted of 136 Iranian patients with cardiovascular disease (65 MetS-affected and 71 MetS un-affected individuals) in the selengene study. Expression of two variants of VIMP including VIMP I and II were analyzed in all subjects using Real-Time PCR and ELISA. RESULTS:The level of VIMP was lower in MetS+ compared to the MetS- subjects (p <0.05). We found no significant differences in quantitative expression of VIMP I and VIMP II in both groups. VIMP I reveal a reverse correlation with fasting blood sugar (FBS) (r = -0.45, p = 0.009). Moreover, SELS in protein level has negative correlation with WC (r = -0.171, p = 0.049) and positive correlation with HDL (r = 0.176, p = 0.046). CONCLUSIONS:Our study suggests that VIMP in protein level is significantly lower in MetS and shows a reverse correlation with WC and positive correlation with HDL. Therefore, with regard to the functional role of this protein, it is possible to deduce that its lower expression leads to the higher secretion of unfolded proteins into the cytosol and outside the cell, where they cannot play their exact roles in the different pathways. Moreover, the reverse correlation of VIMP I with FBS suggests further consideration of VIMP and its variant VIMP I expression in regards to potential development of major CVD risk factors.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Gharipour M,Behmanesh M,Salehi M,Vaseghi G,Nezafati P,Dianatkhah M,Khosravi E,Hosseini M,Sadeghi Mdoi
10.1016/j.arcmed.2020.05.005subject
Has Abstractpub_date
2020-08-01 00:00:00pages
535-541issue
6eissn
0188-4409issn
1873-5487pii
S0188-4409(19)30435-7journal_volume
51pub_type
杂志文章abstract：BACKGROUND:Annually, there are more than 6 million deaths from a type of malignant neoplasia worldwide. In developing countries, the highest rates of incidence of malignant neoplasias are uterine cervical cancer, stomach, lung, esophagus, pharynx, and liver cancers. Recent estimates on the incidence of cancer worldwide...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(01)00290-9
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Injecting a neurotoxin virus into ovary of adult rats has provided morphologic evidence of a multisynaptic neural pathway between ovary and central nervous system (CNS). Vagus nerve is one of the pathways used by CNS to send and receive information to and from the ovary. METHODS:The present study analyzed w...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2004.03.007
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND AND AIMS:In this study, we aimed to investigate whether 1800 MHz frequency electromagnetic radiation (EMR) has an effect on bone healing. METHODS:A total of 30 Wistar albino rats were divided into two equal groups. Fractures were created in the right tibias of all rats; next, intramedullary fixations with K...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2014.01.006
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Because lymphocytes from fragile X patients have been reported as hypersensitive to bleomycin-induced chromatid breaks and because the number of trinucleotide repeats in families with fragile X syndrome has a propensity to expand, we have investigated the possibility that fragile X cells may be hypersensitiv...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(01)00376-9
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND AND AIMS:Jagged1/Notch3 signaling pathway plays a key role in angiogenesis of breast cancer, but little is known in TNBC. This study was designed to investigate the expression of Jagged1/Notch3 mRNA and protein in TNBC, analyze their correlations with clinicopathological characteristics and prognosis. Moreov...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2017.03.014
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive oxygen radical species are involved with the pathophysiology of cisplatin-induced hepatotoxicity. Molsidomine (MOL) can exert antioxidant an...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2013.09.013
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Peroxisome proliferator activated receptor-gamma (PPARgamma) and lipoprotein lipase (LPL) genes are important in pathways of triglyceride metabolism, insulin resistance and adipogenesis. We hypothesized that polymorphisms of PPARgamma Pro12Ala, LPL HindIII and LPL Ser447X influence severity of coron...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2010.01.005
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Metabolic acidosis (MA) is a frequent and serious complication in HIV-infected patients. The aim of the study is to compare patients with and without MA associated with HIV. METHODS:Patients were retrospectively studied involving all HIV-infected patients with blood gas analysis performed during ho...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2008.12.004
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Previous studies investigated the impact of miR-423 rs6505162 C>A polymorphism on individual susceptibility to risk, but the conclusions are still controversial and inconclusive. We performed a meta-analysis to get a more precise and comprehensive assessment of the association between miR-423 rs6505...
journal_title：Archives of medical research
pub_type： 杂志文章,meta分析
doi：10.1016/j.arcmed.2019.04.002
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:A comprehensive understanding of the immune response induced by Mycobacterium bovis Bacille Calmette-Guérin in activation of protective T cells against tuberculosis is important to develop effective therapies to combat this disease. In this study, our experiments were designed to determine effects of transfo...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(02)00463-0
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Further cases of novel influenza A (H1N1) outbreak are expected in the coming months. Vaccination has been proven to be essential to control a pandemic of influenza; therefore, considerable efforts and resources have been devoted to develop a vaccine against the influenza A (H1N1) virus. With the cu...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2010.01.004
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Identifying gene-environment interaction in the context of multiple environmental factors has been a challenging task. We aimed to use conditional inference tree (CTREE) to strata myocardial infarction (MI) risk synthesizing information from both genetic and environmental factors. METHODS:We conduc...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2017.12.001
更新日期：2017-08-01 00:00:00
abstract：:Cervical cancer (CC) is one of the principal public health problems in Mexico. The national mortality rate due to CC was estimated at 21.8 per 100,000 among women over 15 years old during 1994. Despite this high incidence little is known in Mexico about the risk factors for CC. The objectives of the study were to eval...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND AND AIMS:The etiology of atherosclerosis is multifactorial. Genetic and environmental factors are involved in the development of atherosclerosis. Human arylamine N-acetyltransferase 2 (NAT2) is an important metabolizing enzyme that exhibits genetic polymorphisms and modifies individual response and/or toxici...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2010.03.008
更新日期：2010-04-01 00:00:00
abstract：:Nicorandil, the first clinically applied ATP-sensitive K+ channel (K+ATP) opener with nitrate property, has demonstrated cardioprotective effects in patients with multiples of heart diseases. However, it is unknown whether nicorandil has effects on left ventricular (LV) remodeling in rats with ischemic heart failure a...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2018.12.006
更新日期：2018-11-01 00:00:00
abstract：AIMS:To explore the effect of salvianolic acid B (Sal B) on regulation of SIRT3/FOXO1 signaling pathway in rats with non-alcoholic steatohepatitis (NASH). METHODS:Sixty Sprague Dawley (SD) rats were randomly divided into control, model and treatment groups. After 12 weeks of successful model establishment with high fa...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2017.11.016
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Oxidative and endoplasmic reticulum stresses contribute to the pathogenesis of β-cell dysfunction in diabetes mellitus. This study investigates the effect of isopulegol on the above stresses in HFD/STZ induced diabetic rats. METHODS:Animals in group I and II were placed in normal pellet diet and group II wa...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.02.001
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Supplementation with n3 long-chain polyunsaturated fatty acids (n3-LCPUFA) appears to affect body weight, adipokines, and insulin resistance (IR) in obese individuals. However, it is unclear whether the effect on IR is independent of weight loss and if the same effect is observed in children. We und...
journal_title：Archives of medical research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.arcmed.2011.06.010
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:The J wave has been seen in idiopathic ventricular fibrillation, Brugada syndrome, and early repolarization syndrome. Although these conditions share some ECG features, the clinical consequences are markedly different. J wave presentation in healthy subjects is not a rare phenomenon, although its characteris...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.08.006
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Distal renal tubular acidosis (dRTA) is characterized by a reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. Mutations in the SLC4A1 gene have been found to cause either autosomal dominant (AD) or autosomal recessive (AR)...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2012.05.001
更新日期：2012-05-01 00:00:00
abstract：BACKGROUNDS AND AIMS:Selenium nanoparticles (SeNPs) have been reported to exhibit an inhibitory effect on cancer cells. In the present study, we aimed to compare the in vitro and in vivo effects of SeNPs and folic acid surface-coated selenium nanoparticles (FA@SeNPs) on breast cancer. METHODS:FA@SeNPs and SeNPs were c...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2018.04.007
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND AND AIMS:In previous studies, the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2) was shown to be associated with both lipid metabolism and longevity. We examined whether the polymorphism continued to be associated with abnormal levels of serum lipid/lipoprotein amon...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2011.09.010
更新日期：2011-10-01 00:00:00
abstract：:Despite that the human gastrointestinal tract is the most populated ecological niche by bacteria in the human body, much is still unknown about its characteristics. This site is highly susceptible to the effects of many external factors that may affect in the quality and the quantity of the microbiome. Specific factor...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2017.11.004
更新日期：2017-11-01 00:00:00
abstract：:Amebic liver abscess (ALA) is associated with a state of transient suppression of cell-mediated immunity (CMI). T4 helper-inducer cell number is reported to be reduced. However, little is known of the reason for such reduction. Adenosine deaminase (ADA), an enzyme of salvage pathway in purine metabolism, is reported t...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Policosanol, a defined mixture of high molecular weight aliphatic alcohol isolated and purified from sugar cane (Saccharum officinarum, L) wax is a new cholesterol-lowering agent effective in experimental models, healthy volunteers, and patients with type II hypercholesterolemia. Also, policosanol prevents the onset o...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:The E. histolytica rDNA episome consists of a 3.7 kb HindIII fragment located downstream of the rDNA inverted repeats. We have determined the complete nucleotide sequence of this fragment and have shown that it is comprised of two families of short tandem repeats, the 170 bp DraI repeat and the 144 bp ScaI repeat. Eac...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outsid...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2014.11.010
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:There is a need to assess whether human immunodeficiency virus (HIV)-infected patients are more likely than noninfected individuals to have any of the specific lipoprotein combination profiles identified as the best predictors of future cardiovascular disease in the general population. METHODS:One hundred f...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.06.012
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Lipoprotein(a) [Lp(a)] is an independent cardiovascular risk factor. We present real-life characteristics of patients with increased Lp(a) levels attending a University Lipid Clinic. METHODS:We retrospectively studied patients attending the University of Ioannina Hospital Lipid Clinic with Lp(a) levels ≥30 m...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.12.003
更新日期：2020-12-27 00:00:00
abstract：BACKGROUND:Cisplatin is a widely used chemotherapy agent that has several adverse effects, such as ototoxicity. Evaluation of hearing loss due to cisplatin therapy in children is difficult. The purpose of this study was to compare the validity of distortion product otoacoustic emissions (DPOAEs) with pure tone audiomet...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/S0188-4409(03)00022-5
更新日期：2003-05-01 00:00:00
