Abstract:
BACKGROUND:Adrenoceptors have been involved in the regulation of hepatocyte proliferation after partial hepatectomy, as well as in primary culture. This report characterizes alpha 1- and beta-adrenoceptor change during the time-course of liver regeneration in adult Wistar Kyoto rats. METHODS:Saturation binding assays with [3H]prazosin or [3H]dihydroalprenolol (for alpha 1- and beta-adrenoceptors, respectively) were done in liver plasma membranes from 6-month-old rats subjected to 70% hepatectomy followed by hepatic regeneration. RESULTS:[3H]Prazosin and [3H]dihydroalprenolol binding gave control Bmax values of 101 +/- 10 and 12 +/- 1 fmol/mg protein and Kd of 0.50 +/- 0.10 and 4.1 +/- 0.4 nM for alpha 1- and beta-adrenoceptors, respectively. alpha 1-Adrenoceptor number and Kd increased at 24 and 48 h and returned to control values at 72 and 96 h after surgery, whereas beta-adrenoceptors augmented at 48 and 72 h, with a Kd change at 24 and 48 h posthepatectomy. CONCLUSIONS:These results suggest that dual control of alpha 1- and beta-adrenoceptor membrane expression could be involved in different steps during hepatocyte proliferation, and that Wistar Kyoto rats have a different adrenoceptor pattern expression from other rat strains.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Reyes-Salcido V,Villalobos-Molina Rdoi
10.1016/s0188-0128(98)00028-1subject
Has Abstractpub_date
1999-03-01 00:00:00pages
89-92issue
2eissn
0188-4409issn
1873-5487pii
S0188-0128(98)00028-1journal_volume
30pub_type
杂志文章abstract::One of the mechanisms that Entamoeba histolytica uses to evade host immune response is inhibition of the polymorphonuclear (PMN) leukocyte respiratory burst. In studies previously conducted in a model used in our laboratory, we observed that when treating trophozoites with different zinc concentrations certain amebic ...
journal_title:Archives of medical research
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abstract:BACKGROUND:Antiepileptics including benzodiazepines have long been recognized to provoke seizures and precipitate status epilepticus occasionally. This has a special clinical importance in the case of diazepam because of its use as first choice medication in its management. This report is intended to highlight the clin...
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abstract:BACKGROUND:It is well documented that Giardia duodenalis undergoes surface antigenic variation both in vivo and in vitro. Proteins involved have been characterized and referred to as VSP (variable surface protein). METHODS:Two cloned cDNA inserts of 0.45 and 1.95 kb were obtained from G. duodenalis expression library ...
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journal_title:Archives of medical research
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abstract:BACKGROUND:Studies of breast cancer etiology suggest evidence that night shift working and occupational exposure to ionizing radiation (IR) are defined risk factors for breast cancer development. There are few studies to clarify neuroendocrine and inflammatory status and the possible consequences particularly in occupa...
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journal_title:Archives of medical research
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abstract:BACKGROUND:American trypanosomiasis (Chagas' disease), an anthropozoonosis fairly common in rural Latin America, has become an urban disease due to continuous migration, intra- and internationally. Blood transfusion, the second important pathway for transmission, increases its impact. Recognition of seropositive subjec...
journal_title:Archives of medical research
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journal_title:Archives of medical research
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更新日期:1997-01-01 00:00:00
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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doi:10.1016/j.arcmed.2011.12.005
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journal_title:Archives of medical research
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doi:
更新日期:1997-04-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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更新日期:1993-04-01 00:00:00
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