Abstract:
BACKGROUND:We undertook this study to analyze serum and platelet gamma-glutamyltransferase (GGT) activity and total antioxidant status (TAS) concentration during the course of pneumonia and to compare them between patients with normal platelet count and those who developed reactive thrombocytosis. METHODS:Platelet count, GGT activity and TAS concentration in serum (S) and platelet (Plt) isolates were measured in 60 patients with community-acquired pneumonia (CAP) on admission and at discharge. RESULTS:At the end of treatment, platelet count increased significantly from the value recorded on admission. By the end of treatment, 42% of patients developed reactive thrombocytosis. Serum and platelet GGT activity was higher, whereas (S)TAS was significantly lower in CAP patients than in control subjects. On admission, (Plt)TAS was significantly higher in CAP patients as compared with control subjects; at discharge, (Plt)TAS was lower in comparison with either patient admission and control subjects. GGT activity and TAS concentration in serum and platelet isolate on admission did not differ significantly between patients with and without thrombocytosis. At discharge, (S)GGT activity showed no significant changes, whereas (Plt)GGT decreased significantly in patients with thrombocytosis as compared with those without thrombocytosis. In patients with thrombocytosis, (S)TAS concentration showed no significant difference, whereas (Plt)TAS concentration measured at discharge was significantly lower in patients with thrombocytosis as compared to those with normal platelet count. CONCLUSIONS:The pattern of changes in (Plt)GGT catalytic activity and TAS concentration might be indicative of a certain role of thrombocytosis during treatment in patients with CAP. Further investigations are necessary to clarify these changes.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Laskaj R,Dodig S,Cepelak I,Kuzman Idoi
10.1016/j.arcmed.2007.01.005subject
Has Abstractpub_date
2007-05-01 00:00:00pages
424-31issue
4eissn
0188-4409issn
1873-5487pii
S0188-4409(07)00035-5journal_volume
38pub_type
杂志文章abstract:BACKGROUND:Bisalbuminemia is a dysproteinemia characterized by the occurrence of two albumin fractions on serum protein separation by electrophoresis on cellulose acetate sheets. Bisalbuminemia may occur as a hereditary trait or as analytical interference with some drugs, especially penicillin. METHODS:Two patients wi...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(00)00251-4
更新日期:2000-11-01 00:00:00
abstract::In Mexico, hypercholesterolemia has become a major public health problem particularly in the states of the north of the country and in Mexico City, where a prevalence of 20% has been reported. Schemes of treatment have now been reinforced by the appearance of new cholesterol reducing drugs. The objective of the study ...
journal_title:Archives of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Urinalysis is one of the most common studies performed on the diabetic patient at every visit. The presence of leukocyturia is relatively common but it is not clear what the attitude of the physician toward this particular finding should be. The main objective of the present study was to investigate the clin...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(00)00072-2
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Annually, there are more than 6 million deaths from a type of malignant neoplasia worldwide. In developing countries, the highest rates of incidence of malignant neoplasias are uterine cervical cancer, stomach, lung, esophagus, pharynx, and liver cancers. Recent estimates on the incidence of cancer worldwide...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(01)00290-9
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:The present study was designed to examine whether resveratrol, a potent antioxidant, protects against renal ischemia-reperfusion (I/R) injury. METHODS:Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 6 h of reperfusion. Resveratrol (RVT, 30 m...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2006.04.003
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Metabolic syndrome (MetS) is a disorder that includes a cluster of several risk factors for the development of type 2 diabetes and cardiovascular disease. The R230C variant of the ABCA1 gene has been associated with low HDL-cholesterol in several studies, but its association with MetS in children re...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2015.07.008
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Cellular events in cisplatin-mediated nephrotoxicity include apoptosis induction, decreased protein synthesis, changes in the subcellular redistribution of Bax mitochondrial dysfunction, DNA injury, increased lipid peroxidation, depletion of glutathione and decrease in enzymatic activity of renal antioxidant...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2006.02.008
更新日期:2006-08-01 00:00:00
abstract::Adhesion of trophozoites to target cells in the host intestine is the first of three consecutive steps (adherence, cytolytic effect and phagocytosis) involved in the invasion of colonic tissue by E. histolytica. To investigate the possible participation of the local secretory immune response in the interference with t...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Many studies indicate that the production of reactive oxygen species (ROS) after renal ischemia/reperfusion (I/R) may initiate the cascade of cellular injury. It has been demonstrated that ozone oxidative preconditioning (OzoneOP) may prevent the damage induced by ROS and attenuate renal I/R injury. On the b...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2007.09.005
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Wind instrument playing requires a strenuous respiratory activity. Previous studies investigating effect of wind instrument playing on pulmonary function are equivocal. METHODS:In the present study, 34 male, non-smoker wind players in a military band were compared with 44 healthy non-smoker males by pulmona...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2005.09.015
更新日期:2006-05-01 00:00:00
abstract::In this report we show the chromosomal changes seen in a group of 303 Mexican patients with de novo Acute Myeloblastic Leukemia (AML). Two hundred forty-two patients were diagnosed and treated at two hospitals affiliated with the Instituto Mexicano del Seguro Social (IMSS). These are the Centro Medico Nacional Siglo X...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::A prospective study to evaluate the role of vitamin C and cervico-vaginal infection in the premature rupture of amniotic membranes (PROM) was designed. The leukocyte vitamin C levels of 44 pregnant women that did not consume vitamin supplements was evaluated at weeks 20, 28 and 32 of pregnancy. On each evaluation the ...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Immunity in leishmaniasis is mediated by T cells, but protective responses in humans have not been fully defined. In this study, the functional activity of CD4+ T cell clones derived from an immune individual was investigated to identify potentially protective responses. The T cells proliferated and produced interfero...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:Lipoprotein(a) [Lp(a)] is an independent cardiovascular risk factor. We present real-life characteristics of patients with increased Lp(a) levels attending a University Lipid Clinic. METHODS:We retrospectively studied patients attending the University of Ioannina Hospital Lipid Clinic with Lp(a) levels ≥30 m...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2020.12.003
更新日期:2020-12-27 00:00:00
abstract:BACKGROUND AND AIMS:It remains unclear whether U50488H (a selective kappa-opioid receptor agonist) produces anti-apoptotic effect during ischemia and reperfusion (I/R). Therefore, the effect of U50488H on myocardial apoptosis was investigated in the present study. METHODS:Rats were subjected to 45min coronary artery o...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2009.04.009
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in developing countries. The aim of the study was to determine the association between serum CD26 concentration and outcome of patients with ESCC. METHODS:A total of 183 patients with ESCC and 254 healthy controls were selected. Blo...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2016.07.005
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND AND AIMS:In previous studies, the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2) was shown to be associated with both lipid metabolism and longevity. We examined whether the polymorphism continued to be associated with abnormal levels of serum lipid/lipoprotein amon...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2011.09.010
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND AIMS:To explore hepatoprotective action of curcumin (CMN, a bioflavonoid) on oxaliplatin (Oxa)-triggered mitochondrial oxidative stress and respiratory chain complexes in liver of rats. Oxa is a ubiquitously utilized platinum-based chemotherapeutic agent commonly used for the treatment of colorectal canc...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2017.01.010
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:We assessed the auditory function of 94 patients with type 2 diabetes mellitus and 94 age- and sex-matched healthy subjects. METHODS:To study the influence of the clinical characteristics of the disease on the auditory function, after a clinical interview with ophthalmological assessment, subjects were eval...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2005.02.002
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The frequency of neurologic manifestations of the central nervous system (CNS) as a defining disease of acquired immunodeficiency syndrome (AIDS) (neurologic manifestation defining disease [NMDD-AIDS]) varies according to geographic region. The aim of this study was to determine its prevalence among patients...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2003.07.004
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Phosphodiesterases 5 and 9 (PDE5, PDE9) are enzymes responsible for regulating second messenger signaling by hydrolyzing 3',5' cyclic guanosine monophosphate (cGMP). PDE isoforms are deregulated in some types of human cancer. The present study was carried out to evaluate the expression of phosphodie...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2012.08.006
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND AND AIM:Oxalobacter formigenes is an intestinal bacterium that utilizes oxalate as the only source of energy. It has been suggested that the lack of colonization with this organism may be a risk factor for calcium oxalate urolithiasis. Because this problem was not investigated in pediatric stone formers, we ...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2009.05.004
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Coronary artery disease is the significant cause of morbidity and mortality today. The treatment of coronary artery disease is improving, but its prevalence is increasing. Both primary and secondary prevention measures are of vital importance. METHODS:In this study, vitamin C, total antioxidant status, malo...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(01)00381-2
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Little is known about the potential relationship of obesity, adipose tissue and novel adipokines with cardiometabolic risk factors in end-stage renal disease. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with proposed desirable effects on inflammation, and lipid and ...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2017.10.004
更新日期:2017-07-01 00:00:00
abstract::The amebicidal action of metronidazole is activated when the enzyme pyruvate:ferredoxin oxido-reductase transfers reducing equivalents to the nitro group of the drug. The enzyme is present in Entamoeba histolytica and other anaerobic parasites like Giardia and Trichomonas that lack mitochondria. The selectivity of the...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
doi:
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Injecting a neurotoxin virus into ovary of adult rats has provided morphologic evidence of a multisynaptic neural pathway between ovary and central nervous system (CNS). Vagus nerve is one of the pathways used by CNS to send and receive information to and from the ovary. METHODS:The present study analyzed w...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2004.03.007
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Extended-spectrum β-lactamase (ESBLs) production is still the most frequent mechanism of resistance to cephalosporins in gram-negative bacteria. The aim of the study was to identify the types of ESBL-producing Enterobacteriaceae clinical isolates causing nosocomial infections in Mexico. METHODS:ESB...
journal_title:Archives of medical research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.arcmed.2011.02.004
更新日期:2011-02-01 00:00:00
abstract::Glutamate neurotransmitter action on postsynaptic receptors is terminated by its clearance from the synaptic cleft by transporter proteins located in neurons and glial cells. Failure of glutamate removal can lead to neuronal death due to its well-known neurotoxic properties. Glutamate transporters are dependent on ext...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
doi:10.1016/j.arcmed.2005.05.014
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Polymorphisms which are inherited alterations in the activity of cytochrome P450 1B1 (CYP1B1), catechol O-methyltransferase (COMT), manganese superoxide dismutase (MnSOD) hold the potential to define differences in estrogen metabolism and, thereby, possibly explain inter-individual differences in cancer susc...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2004.10.003
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND AIMS:This study is concerned with the expressions of growth-associated protein-43 (GAP-43) mRNA and protein in the anterior horn of the spinal cord after brachial plexus injury. METHODS:Animals were killed 1, 7, 14 days after injury and were divided into three injury groups: group 1, right C(7) ventral ...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2010.10.005
更新日期:2010-10-01 00:00:00