Abstract：
BACKGROUND:The present study was designed to examine whether resveratrol, a potent antioxidant, protects against renal ischemia-reperfusion (I/R) injury. METHODS:Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 6 h of reperfusion. Resveratrol (RVT, 30 mg/kg, i.p.) or vehicle was administered twice, at 30 min prior to ischemia and immediately before the reperfusion period. At the end of the reperfusion period, rats were decapitated and kidney samples were taken for histological examination or determination of levels of renal malondialdehyde (MDA), an end product of lipid peroxidation; glutathione (GSH), a key antioxidant; and myeloperoxidase (MPO) activity, an index of tissue neutrophil infiltration. Formation of reactive oxygen species in hepatic tissue samples was monitored by using chemiluminescence (CL) technique with luminol and lucigenin probes. Renal tissue collagen content as a fibrosis marker was also determined, while serum creatinine and urea concentrations were measured for the evaluation of renal function. Tumor necrosis factor-alpha (TNF-alpha ) and lactate dehydrogenase (LDH) were also assayed in serum samples. RESULTS:Ischemia/reperfusion caused a significant decrease in tissue GSH level, which was accompanied by significant increases in the renal luminol and lucigenin CL values, MDA level, MPO activity and collagen content. Similarly, serum creatinine and BUN levels, as well as LDH and TNF-alpha, were elevated in the I/R group as compared to control group. On the other hand, resveratrol treatment reversed all these biochemical indices, as well as histopathological alterations that were induced by I/R. CONCLUSIONS:Findings of the present study suggest that resveratrol exerts renoprotective effects via its radical scavenging and antioxidant activities, which appear to involve the inhibition of tissue neutrophil infiltration.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Sener G,Tuğtepe H,Yüksel M,Cetinel S,Gedik N,Yeğen BCdoi
10.1016/j.arcmed.2006.04.003subject
Has Abstractpub_date
2006-10-01 00:00:00pages
822-9issue
7eissn
0188-4409issn
1873-5487pii
S0188-4409(06)00154-8journal_volume
37pub_type
杂志文章abstract：BACKGROUND AND AIMS:We undertook this study to investigate the association between CT perfusion characteristics and differentiation grade in lung cancer, as well as the pathological basis of this association. METHODS:Seventy three patients received CT perfusion scan and pathological biopsy, and 30 of them were availab...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2010.11.005
更新日期：2010-11-01 00:00:00
abstract：:Two hundred fifty women with hirsutism were studied, with a mean age of 25.5 years (ranging from 13 to 38 years). The evolution of hirsutism varied from 3 months to 13 years, being minimal in 82 patients (33%), mild to 101 (40%), moderate in 56 (23%) and severe in the remaining 11 women (4%). Polycystic ovary syndrome...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:One of the most frequent malignancies in women worldwide is carcinoma of the uterine cervix. High-risk human papillomavirus (HPV) infection is considered the most important etiological factor of uterine cervical cancer. Our aim was to identify novel cellular genes that could potentially act as predictive mol...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.04.016
更新日期：2005-09-01 00:00:00
abstract：:Amebic liver abscess (ALA) is associated with a state of transient suppression of cell-mediated immunity (CMI). T4 helper-inducer cell number is reported to be reduced. However, little is known of the reason for such reduction. Adenosine deaminase (ADA), an enzyme of salvage pathway in purine metabolism, is reported t...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND AND AIMS:The major limiting factor in therapeutic application of mesenchymal stem cells (MSCs) is their high vulnerability during the early days of transplantation. Hence, researchers have been encouraged to find various strategies to make the cells resistant to different stresses before and after transplant...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2013.03.006
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:A comprehensive understanding of the immune response induced by Mycobacterium bovis Bacille Calmette-Guérin in activation of protective T cells against tuberculosis is important to develop effective therapies to combat this disease. In this study, our experiments were designed to determine effects of transfo...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(02)00463-0
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to provide insight into the interpretation of CK-MB data after major noncardiac surgery. METHODS:Some 3,321 patients who underwent major non-emergent noncardiac procedures (orthopedic 31%, intrathoracic 12%, vascular 22%, other 35%) were studied. All patients had at least two CK sa...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Lung adenocarcinoma (LAC) is a major worldwide cause of death by cancer, it shows high aggressiveness, functional decline, systemic compromise and severe cachexia, which might be counteracted by dietary redox-active phytochemicals. Therefore, our aim was to establish the anticancer effects of the oral intake...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2019.11.006
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The objective of this study was to assess the effect of maternal depressive symptomatology on fat deposition in a group of pregnant adolescents. METHODS:A case-control study was performed with 85 pregnant women (45 adolescents and 40 adults) who attended a prenatal care course at a teaching hospital in Mexi...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(00)00041-2
更新日期：2000-01-01 00:00:00
abstract：:The effect of electric field stimulation for promoting axonal growth between sural to facial nerve grafts in cases of congenital permanent facial palsy associated with hemifacial microsomia was studied. For this purpose, a total of 17 patients with unilateral congenital permanent facial palsy associated with hemifacia...
journal_title：Archives of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-04-01 00:00:00
abstract：:Classical descriptions of the pathology of amebiasis portray the parasite as the cause of tissue damage and destruction, and in recent years a number of amebic molecules have been identified as virulence factors. In this review we describe a series of experiments that suggest a more complex host-parasite relation, at ...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2005.10.007
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Thymectomy is considered the most effective treatment for achieving sustained improvement as well as remission in patients with myasthenia gravis (MG), and most neurologists favor the use of this procedure. The main focus of many current studies is to determine response-predicting factors. METHODS:Clinical ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(02)00405-8
更新日期：2002-11-01 00:00:00
abstract：:During the past few years, an increasing set of evidence has supported the major role of deregulation of the interaction patterns between glial cells and neurons in the pathway toward neuronal degeneration. Neurons and glial cells, together with brain vessels, constitute an integrated system for brain function. Inflam...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2007.10.001
更新日期：2008-01-01 00:00:00
abstract：:Global warming has serious implications for all aspects of human life, including infectious diseases. The effect of global warming depends on the complex interaction between the human host population and the causative infectious agent. From the human standpoint, changes in the environment may trigger human migration, ...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2005.03.041
更新日期：2005-11-01 00:00:00
abstract：:Genetic alterations in tumors, as predictor of response to targeted-therapies or as prognostic markers, are clinically relevant to determine adequate therapeutic management. Tumor biopsy is currently the golden standard for somatic alterations assessment, but this approach is invasive and does not consider tumor heter...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2018.10.007
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:We undertook this study to compare the effectiveness and safety of antenatal daily and weekly supplementation with iron, folic acid, and vitamin B(12) in healthy, pregnant women who were not anemic at gestational week 20. METHODS:Women with singleton pregnancies and blood hemoglobin (Hb) >115 g/L at gestati...
journal_title：Archives of medical research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.arcmed.2005.11.011
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to determine concentrations of tumor necrosis factor-alpha (TNF-alpha) in normal, painful, and asymptomatic human dental pulps. METHODS:Pulps were obtained from three groups of teeth, including healthy teeth, asymptomatic teeth with caries and/or large restoration, and symptomatic ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(02)00396-x
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:Short tandem repeats (STRs) on the non-pseudoautosomal region of the Y-chromosome are DNA polymorphic markers able to solve special cases in legal medicine, for instance in paternity testing where the alleged father is not available, and in forensic situations, such as rape cases, where mixtures of male/fema...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(01)00266-1
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:Although several studies have identified factors associated with bone mineral density (BMD), little research is available on Mexican women. METHODS:A cross-sectional study was conducted in 1,622 female workers between 20 and 80 years of age at the Mexican Social Security Institute (IMSS), an integral part o...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2003.12.001
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND AND AIMS:This study was designed to identify susceptibility to insulin resistance and the association of serum resistin and adiponectin with insulin resistance in patients with Behçet's disease (BD). Also, we identify risk determinants for insulin resistance in BD patients. METHODS:The study population cons...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2010.05.008
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:It is well documented that Giardia duodenalis undergoes surface antigenic variation both in vivo and in vitro. Proteins involved have been characterized and referred to as VSP (variable surface protein). METHODS:Two cloned cDNA inserts of 0.45 and 1.95 kb were obtained from G. duodenalis expression library ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2003.12.005
更新日期：2004-05-01 00:00:00
abstract：:Idiopathic ventricular tachycardia is a well described syndrome of both left and right ventricular origin. This study reports the feasibility and efficacy of catheter ablation in this entity. Fourteen patients (mean age 30 +/- 10 years of age) and six patients (mean age 51 +/- 9 years of age) underwent endocardial cat...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:Policosanol, a defined mixture of high molecular weight aliphatic alcohol isolated and purified from sugar cane (Saccharum officinarum, L) wax is a new cholesterol-lowering agent effective in experimental models, healthy volunteers, and patients with type II hypercholesterolemia. Also, policosanol prevents the onset o...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:Wind instrument playing requires a strenuous respiratory activity. Previous studies investigating effect of wind instrument playing on pulmonary function are equivocal. METHODS:In the present study, 34 male, non-smoker wind players in a military band were compared with 44 healthy non-smoker males by pulmona...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.09.015
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Little is known about the potential relationship of obesity, adipose tissue and novel adipokines with cardiometabolic risk factors in end-stage renal disease. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with proposed desirable effects on inflammation, and lipid and ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2017.10.004
更新日期：2017-07-01 00:00:00
abstract：:The most frequent cause of preventable blindness in adults, in the developed world, is diabetic retinopathy (DR). The early treatable phase of this complication is clinically silent. In order to institute effective laser photocoagulation and prevention of blindness, timely detection is crucial. Consequently there is a...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND:Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating IL-19 in acute ST-segment elevation myocardial infarction (STEMI) patients was detected....
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.01.007
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Bacteremia is a common serious manifestation of disease in the intensive care unit (ICU), which requires quick and accurate determinations of pathogens to select the appropriate antibiotic treatment. To overcome the shortcomings of traditional bacterial culture (BC), we have adapted next-generation ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2016.08.004
更新日期：2016-07-01 00:00:00
abstract：:E. histolytica, pathogenic, and E. dispar, non-pathogenic, being morphologically identical are, when recovered as cysts in feces, diagnosed as E. histolytica. A survey on The Seychelles demonstrated that when culture and zymodeme characterization was used to compare against microscopy alone, the risk of overdiagnosis ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Heroin abuse causes various medical and surgical complications. We report a case of heroin-induced severe bilateral compartment syndrome complicated by rhabdomyolysis, acute renal failure and extremely elevated creatinine kinase. A 30-year-old male heroin addict presented to the emergency department of Mount Vernon Ho...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.07.013
更新日期：2006-05-01 00:00:00
