Abstract:
BACKGROUND AND AIMS:The major limiting factor in therapeutic application of mesenchymal stem cells (MSCs) is their high vulnerability during the early days of transplantation. Hence, researchers have been encouraged to find various strategies to make the cells resistant to different stresses before and after transplantation. Overexpression of HIF-1α in MSCs to confer resistance against harmful conditions was the aim of this study. METHODS:Using an in vitro approach, we engineered MSCs to overexpress HIF-1α and then evaluated their viability following exposure to hypoxic and oxidative stresses. The inherent expression of HIF-1α was downregulated by siRNA. Viability and apoptosis of the MSCs were then evaluated in vitro following their exposure to hypoxic and oxidative stress conditions. RESULTS:Whereas overexpression of HIF-1α in MSCs was protective against cell death and apoptosis triggered by hypoxic and oxidative stress conditions, its downregulation increased apoptosis and death rate. CONCLUSIONS:Our study is the first to demonstrate how human MSCs can be manipulated to gain protection against stresses that potentially limit their clinical application.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Kiani AA,Kazemi A,Halabian R,Mohammadipour M,Jahanian-Najafabadi A,Roudkenar MHdoi
10.1016/j.arcmed.2013.03.006subject
Has Abstractpub_date
2013-04-01 00:00:00pages
185-93issue
3eissn
0188-4409issn
1873-5487pii
S0188-4409(13)00077-5journal_volume
44pub_type
杂志文章abstract:BACKGROUND AND AIMS:Monocyte chemotactic protein-1 (MCP-1) gene polymorphisms play important roles in regulating immunological reactions and may be associated with pulmonary tuberculosis. However, the relationship between the MCP-1 -2518 gene polymorphism and susceptibility to spinal tuberculosis remains unknown. We un...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2013.12.007
更新日期:2014-02-01 00:00:00
abstract::In contrast to the prophylactic HPV vaccines that exhibit great promise in reducing the burden of cervical cancer, there is limited progress towards the development of immune therapeutic strategies that would help those women who are already infected with high-risk HPV and do not benefit from the current vaccines. The...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
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abstract::The objective of the study was to identify the patterns of recurrence in patients with squamous cell carcinoma of the anal canal (SCCAC) vs. the size of the primary tumor and its further possible impact on its treatment outcome. We reviewed 78 patients treated between 1975 to 1991. They were classified according to to...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
doi:
更新日期:1995-10-01 00:00:00
abstract::Adhesion of trophozoites to target cells in the host intestine is the first of three consecutive steps (adherence, cytolytic effect and phagocytosis) involved in the invasion of colonic tissue by E. histolytica. To investigate the possible participation of the local secretory immune response in the interference with t...
journal_title:Archives of medical research
pub_type: 杂志文章
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journal_title:Archives of medical research
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abstract::Corneal neovascularization is a significant, sight-threatening complication of many ocular surface disorders. Various growth factors and proteinases are involved in corneal neovascularization. The data supporting a causal role for vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are exten...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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journal_title:Archives of medical research
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journal_title:Archives of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:1992-10-01 00:00:00
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journal_title:Archives of medical research
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:A recent revelation about increased susceptibility to HIV by use of nonoxynol-9 (N-9) has called for identification of novel molecules with potent sperm-attenuating activity and lower side-effect profile, as suitable alternatives. The present study was designed to investigate spermicidal activity in Bohadsch...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2008.06.007
更新日期:2008-10-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
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journal_title:Archives of medical research
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(01)00360-5
更新日期:2002-05-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2007.02.004
更新日期:2007-11-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章,meta分析
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更新日期:2020-10-01 00:00:00
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journal_title:Archives of medical research
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更新日期:2015-02-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-05-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2007.10.004
更新日期:2008-04-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2006.11.003
更新日期:2007-04-01 00:00:00
abstract::In order to establish the sensitivity and specificity of transesophageal stress echocardiography with dobutamine (TEE-dobutamine) in the early detection of myocardial ischemia we studied 30 consecutive patients from the Coronary Care Unit (CCU) of the Hospital de Cardiología, Centro Médico Nacional Siglo XXI. The resu...
journal_title:Archives of medical research
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:The design of efficient rabies control programs within a geographic area requires an appropriate knowledge of the local epidemiological cycles. In Latin America, there is a geographical overlap of the two main epidemiological cycles: (a) the terrestrial cycle, where the dog is the main terrestrial vector and...
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更新日期:1999-03-01 00:00:00
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更新日期:2020-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Animal experiments showed that interaction between advanced glycation end products (AGE) and their receptors (RAGE) play an important role in the pathogenesis of diabetic complications. Soluble RAGE (sRAGE) can function as a decoy for RAGE ligands. The present study aimed to examine the levels of AG...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2011.11.001
更新日期:2011-10-01 00:00:00