Weekly iron as a safe alternative to daily supplementation for nonanemic pregnant women.


BACKGROUND:We undertook this study to compare the effectiveness and safety of antenatal daily and weekly supplementation with iron, folic acid, and vitamin B(12) in healthy, pregnant women who were not anemic at gestational week 20. METHODS:Women with singleton pregnancies and blood hemoglobin (Hb) >115 g/L at gestational week 20 (equivalent to 105 g/L at sea level) were randomly assigned to two groups, one consuming one tablet containing 60 mg iron, 200 mug folic acid and 1 mug vitamin B(12) daily (DS, n = 56); the other consuming two tablets once weekly (WS, n = 60). Blood Hb and serum ferritin concentrations were measured every 4 weeks from weeks 20 to 36, and pregnancy outcomes were evaluated. RESULTS:Mild anemia and hypoferritinemia throughout pregnancy occurred less frequently in DS than WS. None of the 116 women had Hb concentrations <103 g/L at any evaluation point. In contrast, hemoconcentration (Hb >145 g/L) from gestational week 28 onwards occurred in 11% in DS and 2% in WS. We observed ex post facto that hemoconcentration at gestational week 28 was associated with a significantly higher relative risk of low birth weight (RR 6.23, 95% CI 1.46-26.57) and premature delivery (RR 7.78, 95% CI 1.45-24.74). CONCLUSIONS:In women who were nonanemic at gestational week 20, both schemes (DS and WS) prevented the occurrence of Hb levels <100 g/L. DS women had a higher incidence of hemoconcentration. Hemoconcentration was associated with increased risk of low birth weight and premature delivery.


Arch Med Res


Casanueva E,Viteri FE,Mares-Galindo M,Meza-Camacho C,Loría A,Schnaas L,Valdés-Ramos R




Has Abstract


2006-07-01 00:00:00














  • Prevalence of overweight and obesity among preschool children from six cities of northeast China.

    abstract:BACKGROUND AND AIMS:This study was carried out to assess and investigate the prevalence of overweight and obesity among preschool-age children living in northeast China using the World Health Organization (WHO), International Obesity Task Force (IOTF) and Centers for Disease Control and Prevention (CDC) standard criter...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Ma YN,Chen T,Wang D,Liu MM,He QC,Dong GH

    更新日期:2011-10-01 00:00:00

  • Roles of Autophagy and Protein Kinase C-epsilon in Lipid Metabolism of Nonalcoholic Fatty Liver Cell Models.

    abstract:OBJECTIVE:To investigate interaction between autophagy and PKC-ε in lipid metabolism of NAFLD cell models. METHODS:HL-7702 cells and SK-HEP-1 cells were cultured in vitro as NAFLD cell models and treated with RAPA to induce autophagy. 3-MA was used to inhibit cell autophagy. And HL-7702 and SK-HEP-1 cell were ordinary...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Yan R,Niu CY,Tian Y

    更新日期:2018-08-01 00:00:00

  • Epidemiologic panorama of stomach cancer mortality in Mexico.

    abstract:BACKGROUND:Annually, there are more than 6 million deaths from a type of malignant neoplasia worldwide. In developing countries, the highest rates of incidence of malignant neoplasias are uterine cervical cancer, stomach, lung, esophagus, pharynx, and liver cancers. Recent estimates on the incidence of cancer worldwide...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Tovar-Guzmán V,Hernández-Girón C,Barquera S,Rodríguez-Salgado N,López-Carrillo L

    更新日期:2001-07-01 00:00:00

  • Efficacy of pravastatin as a hypolipidemic agent in patients with polygenic hypercholesterolemia.

    abstract::In Mexico, hypercholesterolemia has become a major public health problem particularly in the states of the north of the country and in Mexico City, where a prevalence of 20% has been reported. Schemes of treatment have now been reinforced by the appearance of new cholesterol reducing drugs. The objective of the study ...

    journal_title:Archives of medical research

    pub_type: 临床试验,杂志文章


    authors: Aldrete-Velasco J,Casanova JM,Mejía P,Martínez P

    更新日期:1992-10-01 00:00:00

  • Evaluation of the antimeningococcal immunoglobin activity against five strains of Neisseria meningitidis group B from Latin America using mice as model.

    abstract::To know the activity of antimeningococcal immunoglobulin, Balb/c mice of 18-22 g of body weight were challenged with 5 serotype B strains of Neisseria meningitidis (Nm) isolated from patients of different Latin American countries. The specific antimeningococcal Ig was extracted from the serum of volunteers previously ...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Perez-Ramirez PJ,Infante Bourzac JF,Sifontes Rodriguez S,Caro Azoy E,Balboa Gonzalez J,Sierra Gonzalez G,Campa Huergo C,Capo de Paz V

    更新日期:1997-01-01 00:00:00

  • American trypanosomiasis (Chagas' disease) and blood banking in Mexico City: seroprevalence and its potential transfusional transmission risk.

    abstract:BACKGROUND:American trypanosomiasis (Chagas' disease), an anthropozoonosis fairly common in rural Latin America, has become an urban disease due to continuous migration, intra- and internationally. Blood transfusion, the second important pathway for transmission, increases its impact. Recognition of seropositive subjec...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Monteón-Padilla VM,Hernández-Becerril N,Guzmán-Bracho C,Rosales-Encina JL,Reyes-López PA

    更新日期:1999-09-01 00:00:00

  • HIF-1α confers resistance to induced stress in bone marrow-derived mesenchymal stem cells.

    abstract:BACKGROUND AND AIMS:The major limiting factor in therapeutic application of mesenchymal stem cells (MSCs) is their high vulnerability during the early days of transplantation. Hence, researchers have been encouraged to find various strategies to make the cells resistant to different stresses before and after transplant...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Kiani AA,Kazemi A,Halabian R,Mohammadipour M,Jahanian-Najafabadi A,Roudkenar MH

    更新日期:2013-04-01 00:00:00

  • Y-chromosome haplotypes for six short tandem repeats (STRs) in a Mexican population.

    abstract:BACKGROUND:Short tandem repeats (STRs) on the non-pseudoautosomal region of the Y-chromosome are DNA polymorphic markers able to solve special cases in legal medicine, for instance in paternity testing where the alleged father is not available, and in forensic situations, such as rape cases, where mixtures of male/fema...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Rangel-Villalobos H,Jaloma-Cruz AR,Sandoval-Ramírez L,Velarde-Félix JS,Gallegos-Arreola MP,Figuera LE

    更新日期:2001-05-01 00:00:00

  • Anemia in children with and without Helicobacter pylori infection.

    abstract:BACKGROUND:Iron deficiency is the most common cause of anemia in children. Recently there has been evidence to suggest a relationship between Helicobacter pylori gastritis and iron deficiency anemia. Because both H. pylori infection and iron-deficiency anemia are common in children, we studied any correlation between H...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Haghi-Ashtiani MT,Monajemzadeh M,Motamed F,Mahjoub F,Sharifan M,Shahsiah R,Kashef N

    更新日期:2008-07-01 00:00:00

  • Comparative Assessment of Serum Adipokines Zinc-α2-glycoprotein and Adipose Triglyceride Lipase, and Cardiovascular Risk Factors Between Normal Weight and Obese Patients with Hemodialysis.

    abstract:BACKGROUND:Little is known about the potential relationship of obesity, adipose tissue and novel adipokines with cardiometabolic risk factors in end-stage renal disease. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with proposed desirable effects on inflammation, and lipid and ...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Hosseinzadeh-Attar MJ,Mahdavi-Mazdeh M,Yaseri M,Zahed NS,Alipoor E

    更新日期:2017-07-01 00:00:00

  • Comparison of fluoxetine and paroxetine in type II diabetes mellitus patients.

    abstract:BACKGROUND:This study aims to investigate the efficacy of fluoxetine and paroxetine on the levels of depression-anxiety, quality of life, disability, and metabolic control in type II diabetes mellitus (DM) patients. METHODS:The patients were first applied the Hospital Anxiety-Depression Scale (HADS). After a psychiatr...

    journal_title:Archives of medical research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gülseren L,Gülseren S,Hekimsoy Z,Mete L

    更新日期:2005-03-01 00:00:00

  • Extraction and partial characterization of a low molecular weight collagenase from normal rat kidney.

    abstract::A matrix metalloproteinase with selective affinity for collagen was identified and partially purified from normal rat kidney. A two-step purification procedure consisting of gel filtration and affinity chromatography on Sepharose 4B-collagen resulted in an increase in specific activity of more than 3,000 times. The pa...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Vadillo-Ortega F,González-Avila G,Montfort I,Bermejo L,Pérez-Tamayo R

    更新日期:1995-10-01 00:00:00

  • Accelerated mice skin acute wound healing in vivo by combined treatment of argon and helium plasma needle.

    abstract:BACKGROUND AND AIMS:The efficacy of a direct application of plasma needle to in vivo wound healing was experimentally studied in mice. This kind of plasma has achieved considerable success in blood coagulation and tissue restoration in mice. In the development of the present study, an argon plasma needle was chosen for...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: García-Alcantara E,López-Callejas R,Morales-Ramírez PR,Peña-Eguiluz R,Fajardo-Muñoz R,Mercado-Cabrera A,Barocio SR,Valencia-Alvarado R,Rodríguez-Méndez BG,Muñoz-Castro AE,de la Piedad-Beneitez A,Rojas-Olmedo IA

    更新日期:2013-04-01 00:00:00

  • Comparison of pyruvate kinase variants from breast tumor and normal breast.

    abstract:BACKGROUND:Pyruvate kinase isozymes in human breast tumor tissue were compared in this study with normal human breast tissue. Two forms of pyruvate kinase present in normal and tumor human breast were purified by ammonium sulfate precipitation, dialysis, gel filtration, ion exchange, and affinity chromatography. Molecu...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Yilmaz S,Ozan S,Ozercan IH

    更新日期:2003-07-01 00:00:00

  • A single nucleotide polymorphism in the vascular endothelial growth factor gene is associated with recurrence of hepatocellular carcinoma after transplantation.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF), an important regulator of angiogenesis and vascular permeability, is involved in various steps of many malignancies. Gene polymorphisms within the gene encoding VEGF have been shown to be independently associated with an adverse outcome in various malignancies inclu...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Wu LM,Xie HY,Zhou L,Yang Z,Zhang F,Zheng SS

    更新日期:2009-10-01 00:00:00

  • Association of Selenoprotein S Expression and its Variants with Metabolic Syndrome in Subjects with Cardiovascular Disease.

    abstract:BACKGROUND:Selenoproteins S (SELS or VIMP) may regulate cytokine production, and thus play a key role in the control of the inflammatory response. METHODS:This study consisted of 136 Iranian patients with cardiovascular disease (65 MetS-affected and 71 MetS un-affected individuals) in the selengene study. Expression o...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Gharipour M,Behmanesh M,Salehi M,Vaseghi G,Nezafati P,Dianatkhah M,Khosravi E,Hosseini M,Sadeghi M

    更新日期:2020-08-01 00:00:00

  • Lipid profile and anticardiolipin antibodies in Behcet's disease.

    abstract:BACKGROUND:Behcet's disease (BD) is a multisystem disorder characterized by a relapsing inflammatory process of unknown etiology. It is well known that atherothrombosis in systemic inflammatory disorders is closely related to coagulation and lipid metabolism abnormalities. The purpose of this study was to investigate s...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Musabak U,Baylan O,Cetin T,Yesilova Z,Sengul A,Saglam K,Inal A,Kocar IH

    更新日期:2005-07-01 00:00:00

  • Pattern-visual evoked potentials in thinner abusers.

    abstract::Organic solvents cause injury to lipids of neuronal and glial membranes. A well known characteristic of workers exposed to thinner is optic neuropathy. We decided to look for neurophysiologic signs of visual damage in patients identified as thinner abusers. Pattern reversal visual evoked potentials was performed on 34...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Poblano A,Lope Huerta M,Martínez JM,Falcón HD

    更新日期:1996-01-01 00:00:00

  • Epidemiological association between body fat percentage and cervical cancer: a cross-sectional population-based survey from Mexico.

    abstract:BACKGROUND AND AIMS:Various studies have reported a direct association of cervical cancer risk with obesity and weight but not with the body fat percentage (BFP). The aim of this study was to analyze various anthropometric measures as potential risk factors for cervical cancer. METHODS:A total of 20,236 women were inc...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: López-Hernández D

    更新日期:2013-08-01 00:00:00

  • MDR1 C3435T polymorphism in patients with breast cancer.

    abstract:BACKGROUND:The human multidrug-resistant gene (MDR1) encodes P-glycoprotein (Pgp), a membrane-bound efflux transporter conferring resistance to a number of natural cytotoxic drugs and potentially toxic xenobiotics. Single-nucleotide polymorphisms (SNPs) in MDR1 gene are associated with phenotypic variation in Pgp expre...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Turgut S,Yaren A,Kursunluoglu R,Turgut G

    更新日期:2007-07-01 00:00:00

  • Growth deficits in children with sickle cell disease.

    abstract:BACKGROUND:Growth deficits are common in children with sickle cell disease. Few prospective studies are available and the pathophysiologic basis for the impaired growth is not clearly understood. Our objectives were to collect data on anthropomorphic measurements of children with sickle cell disease prospectively follo...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Silva CM,Viana MB

    更新日期:2002-05-01 00:00:00

  • Auditory impairment in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:We assessed the auditory function of 94 patients with type 2 diabetes mellitus and 94 age- and sex-matched healthy subjects. METHODS:To study the influence of the clinical characteristics of the disease on the auditory function, after a clinical interview with ophthalmological assessment, subjects were eval...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Díaz de León-Morales LV,Jáuregui-Renaud K,Garay-Sevilla ME,Hernández-Prado J,Malacara-Hernández JM

    更新日期:2005-09-01 00:00:00

  • Further physicochemical characterization of the monocyte locomotion inhibition factor (MLIF) produced by Entamoeba histolytica.

    abstract::Ultrafiltration, gel-sieve chromatography and HPLC were used to purify MLIF. This material was HCl-hydrolyzed and the amino acids analyzed by HPLC-ortho-ophthaldialdehyde. Two hydrophobic non-polar (ile,leu), two uncharged polar (thr,tyr) and two positively charged (basic) (his, arg) amino acids were found in clear ex...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Díaz-Guerra O,Rico G,Ladrón de Guevara O,Padilla P,García L,Kretschmer RR

    更新日期:1992-01-01 00:00:00

  • Pharmacological Activity of Quercetin and 5 Caffeoylquinic Acid Oral Intake in Male Balb/c Mice with Lung Adenocarcinoma.

    abstract:BACKGROUND:Lung adenocarcinoma (LAC) is a major worldwide cause of death by cancer, it shows high aggressiveness, functional decline, systemic compromise and severe cachexia, which might be counteracted by dietary redox-active phytochemicals. Therefore, our aim was to establish the anticancer effects of the oral intake...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Albrecht C,Cittadini MC,Soria EA

    更新日期:2020-01-01 00:00:00

  • Association between Val158Met functional polymorphism in the COMT gene and risk of preeclampsia in a Chinese population.

    abstract:BACKGROUND AND AIMS:The catechol-O-methyltransferase (COMT) gene is a potential candidate in altering risk for preeclampsia due to the important enzymatic effects in the metabolism of steroid hormones. It contains a non-synonymous G-A base change at codon 158 in the membrane bound isoform, which leads to a valine-to-me...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Liang S,Liu X,Fan P,Liu R,Zhang J,He G,Liu Y,Bai H

    更新日期:2012-02-01 00:00:00

  • TP53 Codon 72 Polymorphism Predicts Efficacy of Paclitaxel Plus Capecitabine Chemotherapy in Advanced Gastric Cancer Patients.

    abstract:BACKGROUND AND AIMS:The present study analyzed the relationship between TP53 codon 72 polymorphisms and the clinical outcome of advanced gastric cancer patients receiving capecitabine plus paclitaxel chemotherapy. METHODS:Three hundred patients with advanced gastric cancer treated with paclitaxel and capecitabine comb...

    journal_title:Archives of medical research

    pub_type: 临床试验,杂志文章


    authors: Zha Y,Gan P,Liu Q,Yao Q

    更新日期:2016-01-01 00:00:00

  • Serum immunoglobulins, IL-1beta, IL-2, and IFN-gamma gamma level in patients with lymphedema treated with ortho-beta-hydroxy-ethyl rutosides (HR).

    abstract:BACKGROUND:This investigation was undertaken to study the clinical characteristics and the humoral immune pattern in lymphedema patients undergoing O-beta-hydroxy-ethyl rutoside therapy. METHODS:A complete physical examination was performed on 27 lymphedema patients (postmastectomy and postphlebitis) and 17 healthy co...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: de Schenquer DG,Schenquer N

    更新日期:2001-03-01 00:00:00

  • Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by kappa-opioid receptor agonist.

    abstract:BACKGROUND AND AIMS:It remains unclear whether U50488H (a selective kappa-opioid receptor agonist) produces anti-apoptotic effect during ischemia and reperfusion (I/R). Therefore, the effect of U50488H on myocardial apoptosis was investigated in the present study. METHODS:Rats were subjected to 45min coronary artery o...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Rong F,Peng Z,Ye MX,Zhang QY,Zhao Y,Zhang SM,Guo HT,Hui B,Wang YM,Liang C,Gu CH,Tao C,Cui Q,Yu SQ,Yi DH,Pei JM

    更新日期:2009-05-01 00:00:00

  • Diet as Regulator of Gut Microbiota and its Role in Health and Disease.

    abstract::In recent years, the gut microbiota has been of great interest due to its role in maintaining health and its association with the development of different diseases such as obesity and diabetes. The objective of the present review is to show the main functions of the gut microbiota, the role in the degradation of compl...

    journal_title:Archives of medical research

    pub_type: 杂志文章,评审


    authors: Sánchez-Tapia M,Tovar AR,Torres N

    更新日期:2019-07-01 00:00:00

  • Cardiovascular risk factors and acculturation in Yaquis and Tepehuanos Indians from Mexico.

    abstract:BACKGROUND:Cardiovascular (CV) risk factors are influenced by behavioral, cultural, and social factors, suggesting that acculturation plays a significant role in the emergency and growth of chronic disease. The objective of this study was to determine the relation between CV risk factors and the main components of accu...

    journal_title:Archives of medical research

    pub_type: 杂志文章


    authors: Rodríguez-Morán M,Guerrero-Romero F,Brito-Zurita O,Rascón-Pacheco RA,Pérez-Fuentes R,Sánchez-Guillén MC,González-Ortiz M,Martínez-Abundis E,Simental-Mendía LE,Madero A,Revilla-Monsalve C,Flores-Martínez SE,Islas-Andrade S,Cruz

    更新日期:2008-04-01 00:00:00