Abstract：
BACKGROUND:Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating IL-19 in acute ST-segment elevation myocardial infarction (STEMI) patients was detected. METHOD:Both plasma IL-19 levels and IL-19 mRNA expression in peripheral blood mononuclear cells (PBMCs) from STEMI patients and chest pain syndrome (CPS) patients were detected at different time points, including 1 d, 3 d, 7 d and 14 d after treatment and on admission. RESULTS:Compared with the CPS patients, IL-19 levels and IL-19 gene expression were significantly increased in STEMI patients and peaked at 1 d. From 1-14 d, refocusing treatment, including emergency percutaneous coronary intervention (PCI) and thrombolysis, markedly reduced IL-19 expression and promoted its recovery; of the treatments, the effect of emergency PCI was most significant. In addition, similar trends were also observed with cTnI, NT-proBNP and C-reactive protein (CRP) levels. Furthermore, correlation analysis showed that IL-19 levels were positively correlated with cTnI, NT-proBNP, CRP levels and left ventricular ejection fraction (LVEF) in STEMI patients. CONCLUSIONS:IL-19 is correlated with the severity of acute myocardial infarction, which may be a new idea for the clinical treatment of myocardial infarction.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Qi L,Zhang J,Wu K,Shi S,Ji Q,Miao H,Que Bdoi
10.1016/j.arcmed.2020.01.007subject
Has Abstractpub_date
2020-02-01 00:00:00pages
160-166issue
2eissn
0188-4409issn
1873-5487pii
S0188-4409(19)30958-0journal_volume
51pub_type
杂志文章abstract：BACKGROUND:Gamma-irradiation of platelet concentrates may inactive contaminated lymphocytes and subsequently inhibit the synthesis of cytokine in platelet during storage. The aim of this study was to determine the effect of gamma-irradiation on the production of IL-8 and lymphocyte proliferation isolated from random do...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2008.05.004
更新日期：2008-08-01 00:00:00
abstract：:We report a study on the DNA organization in Entamoeba histolytica using a ribosomal DNA probe. The rDNA genes were found forming mers which were separated in a typical ladder pattern by pulse field electrophoresis. DNA rosette structures were visualized through electron microscopy in DNA eluted from bands recognized ...
journal_title：Archives of medical research
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doi：
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abstract：BACKGROUND:Studies in platelet of 5-HT uptake transporters have been performed using binding assay methodology designed for ligand-receptor interactions; however, uptake transporters present requirements that may question the validity of these particular binding assays. METHODS:To explore methodologic aspects that may...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2003.03.001
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abstract：:Diabetes mellitus type II, a cause of preclinical left ventricular dysfunction that can progress to cardiac insufficiency ventricular dysfunction in diabetic patients, is attributed to systemic arterial hypertension, or ischemic cardiopathy. Diastolic ventricular dysfunction takes place during the course of diabetes m...
journal_title：Archives of medical research
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doi：10.1016/s0188-4409(00)00264-2
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abstract：:Intracellular communication is an essential process in both embryological development and for the maintenance of normal tissue physiology. We have established the presence of this type of communication between endothelial cells and vascular smooth muscle cells in man and have here investigated the close contacts betwe...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:This investigation was undertaken to study the clinical characteristics and the humoral immune pattern in lymphedema patients undergoing O-beta-hydroxy-ethyl rutoside therapy. METHODS:A complete physical examination was performed on 27 lymphedema patients (postmastectomy and postphlebitis) and 17 healthy co...
journal_title：Archives of medical research
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journal_title：Archives of medical research
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journal_title：Archives of medical research
pub_type： 杂志文章,评审
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journal_title：Archives of medical research
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journal_title：Archives of medical research
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journal_title：Archives of medical research
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doi：10.1016/j.arcmed.2004.03.007
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journal_title：Archives of medical research
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doi：10.1016/j.arcmed.2005.07.011
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doi：10.1016/j.arcmed.2009.07.011
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journal_title：Archives of medical research
pub_type： 杂志文章,评审
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更新日期：2015-07-01 00:00:00
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journal_title：Archives of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Archives of medical research
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journal_title：Archives of medical research
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doi：
更新日期：1992-01-01 00:00:00
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更新日期：2011-11-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Monocyte chemotactic protein-1 (MCP-1) gene polymorphisms play important roles in regulating immunological reactions and may be associated with pulmonary tuberculosis. However, the relationship between the MCP-1 -2518 gene polymorphism and susceptibility to spinal tuberculosis remains unknown. We un...
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更新日期：2014-02-01 00:00:00
