Abstract：
BACKGROUND:Myocardial infarction (MI) is one of the most important diseases that has stimulated interest in understanding cardiac function recovery. SDF-1 is a chemotactic factor and a pro-angiogenic molecule; SDF-1 degradation is inhibited by dipeptidyl peptidase-4 (DPP4) inhibitors, such as vildagliptin. We investigated whether vildagliptin affects angiogenesis in MI and improves cardiac function recovery. METHODS:We established a therapeutic strategy using vildagliptin and G-CSF treatment to improve cardiac function recovery after MI in mice. RESULTS:Vildagliptin treatment increased the myocardial homing of circulating CXCR4+ stem cells and angiogenesis. The combination of vildagliptin and G-CSF treatment attenuated cardiac remodeling and improved survival and cardiac function after MI. Vildagliptin treatment induced active SDF-1, which preserved the cardiac SDF-1-CXCR4 homing axis for MI injury. CONCLUSION:Vildagliptin and G-CSF induced stem cell mobilization and increased angiogenesis as a therapeutic strategy for improving survival and cardiac function after MI.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Li M,Wang Z,Xia H,Yu L,Hu Zdoi
10.1016/j.arcmed.2019.07.004subject
Has Abstractpub_date
2019-04-01 00:00:00pages
133-141issue
3eissn
0188-4409issn
1873-5487pii
S0188-4409(18)30701-Xjournal_volume
50pub_type
杂志文章abstract：:Public and governmental concern regarding increasing cancer mortality trends in children in Mexico led us to investigate the current situation of childhood cancer in this country, as well as to discuss the reasons for which no decline in total and childhood cancer mortality has been documented during the past decades....
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(00)00094-1
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abstract：BACKGROUND AND AIMS:An increasing number of studies have been published concerning meeting targets of clinical guidelines for different aspects of the diagnosis and treatment of patients with end-stage renal disease. Most of these studies have shown that guideline recommendations are not always satisfied, and results o...
journal_title：Archives of medical research
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.05.010
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abstract：BACKGROUND AND AIMS:The use of automated peritoneal dialysis (APD) is increasing compared to continuous ambulatory peritoneal dialysis (CAPD). Surprisingly, little data about health benefits and cost of APD exist, and virtually no information comparing the cost-utility between CAPD and APD is available. We undertook th...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2013.10.017
更新日期：2013-11-01 00:00:00
abstract：:Corneal neovascularization is a significant, sight-threatening complication of many ocular surface disorders. Various growth factors and proteinases are involved in corneal neovascularization. The data supporting a causal role for vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are exten...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2007.04.006
更新日期：2007-10-01 00:00:00
abstract：:Acute myeloid leukemia (AML) is a clonal disorder defined by the accumulation of abnormally differentiated myeloid cells that are not mature; any myeloid lineage can be affected and the extent of maturation of the leukemia blasts can also vary. Because mature blast cells of AML have very limited proliferative capacity...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
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journal_title：Archives of medical research
pub_type： 杂志文章
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.12.001
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journal_title：Archives of medical research
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pub_type： 杂志文章
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更新日期：2010-11-01 00:00:00
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更新日期：2016-10-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(02)00370-3
更新日期：2002-07-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2005.03.041
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.08.006
更新日期：2008-02-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2017.11.016
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Thyroid hormones exert important effects on heart remodeling through mir-208. The process may have a role in myocardial changes in chronic kidney disease where thyroid abnormalities are common. In this study the effect of T4 supplementation on left ventricle (LV) remodeling in 5/6 nephrectomized rat...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2013.11.005
更新日期：2013-11-01 00:00:00
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doi：
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pub_type： 杂志文章,随机对照试验
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更新日期：2011-08-01 00:00:00
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更新日期：2010-05-01 00:00:00
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更新日期：2012-02-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
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更新日期：2011-02-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.04.015
更新日期：2006-01-01 00:00:00
abstract：:COVID-19 is a devastating global pandemic around the world. While the majority of infected cases appear mild, in some cases individuals present respiratory complications with possible serious lung damage. There are no specific treatments for COVID-19 as yet, though a number are under evaluation, including experimental...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.04.018
更新日期：2020-08-01 00:00:00
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journal_title：Archives of medical research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-09-01 00:00:00
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journal_title：Archives of medical research
pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0188-4409(01)00360-5
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Polymorphisms which are inherited alterations in the activity of cytochrome P450 1B1 (CYP1B1), catechol O-methyltransferase (COMT), manganese superoxide dismutase (MnSOD) hold the potential to define differences in estrogen metabolism and, thereby, possibly explain inter-individual differences in cancer susc...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2004.10.003
更新日期：2005-01-01 00:00:00
