Abstract：
:Corneal neovascularization is a significant, sight-threatening complication of many ocular surface disorders. Various growth factors and proteinases are involved in corneal neovascularization. The data supporting a causal role for vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are extensive. Inhibition of VEGF and MMPs is a main strategy for treating corneal neovascularization. Several findings have shown that corneal neovascularization can be reduced by using anti-VEGF and anti-MMPs agents. Efficacy of a nutrient mixture (NM) containing lysine, proline, ascorbic acid, and green tea extract has been demonstrated for reducing VEGF and MMPs secretion by various cells. Moreover, NM can inhibit endothelial cell migration and capillary tube formation. We herein note that topical application of NM is potentially useful for inhibiting corneal neovascularization and restoration of corneal clarity. Further investigations in animal models are needed to place NM alongside corneal neovascularization therapeutics.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Shakiba Y,Mostafaie Adoi
10.1016/j.arcmed.2007.04.006subject
Has Abstractpub_date
2007-10-01 00:00:00pages
789-91issue
7eissn
0188-4409issn
1873-5487pii
S0188-4409(07)00134-8journal_volume
38pub_type
杂志文章,评审abstract：:During the late 1940s, Alfred Jost demonstrated that mammalian sex differentiation begins in fetal testis, producing two factors necessary for the establishment of phenotypic males. Castrated embryos prior to testis differentiation led to phenotypic female differentiation. Jost proposed the existence of a testis-deter...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/s0188-4409(01)00317-4
更新日期：2001-11-01 00:00:00
abstract：:The identification of human IgG immunoglobulins on the surface of Vibrio cholerae O1, and Haemophilus influenzae type b microorganisms was assessed via a flow cytometric technique. A group of 31 healthy mother-full term newborn duo sera from a non-endemic cholera area was assayed. The sera of mothers and full-term new...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:It remains unclear whether the activation of kappa-opioid receptors has strong hypotensive effects under hypertensive condition, and the underlying mechanisms have not yet been investigated. Therefore, the present study is designed to use spontaneously hypertensive rats (SHR) to investigate the effects of a ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.04.009
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:Lipoprotein(a) [Lp(a)] is an independent cardiovascular risk factor. We present real-life characteristics of patients with increased Lp(a) levels attending a University Lipid Clinic. METHODS:We retrospectively studied patients attending the University of Ioannina Hospital Lipid Clinic with Lp(a) levels ≥30 m...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.12.003
更新日期：2020-12-27 00:00:00
abstract：BACKGROUND:Angiotensin converting enzyme (ACE) inhibitors and angiotensin II AT1-receptor antagonists prolong survival in experimental postischemic heart failure (CHF) in rats. The aim of this study was to investigate whether potential beneficial effects of early and long-term therapy with low doses of captopril or los...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/S0188-4409(03)00076-6
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND AND AIMS:As a newly discovered B-cell subset, PDCA-1(+) B cells have been shown to participate in the immune clearance of invading pathogens. The prominence of PDCA-1(+) B cell immunity in the pathogenesis of Helicobacter pylori infection prompted us to explore the potential role of this subset in gastric H....
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2016.04.003
更新日期：2016-02-01 00:00:00
abstract：:The amebicidal action of metronidazole is activated when the enzyme pyruvate:ferredoxin oxido-reductase transfers reducing equivalents to the nitro group of the drug. The enzyme is present in Entamoeba histolytica and other anaerobic parasites like Giardia and Trichomonas that lack mitochondria. The selectivity of the...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1996-10-01 00:00:00
abstract：:Organic solvents cause injury to lipids of neuronal and glial membranes. A well known characteristic of workers exposed to thinner is optic neuropathy. We decided to look for neurophysiologic signs of visual damage in patients identified as thinner abusers. Pattern reversal visual evoked potentials was performed on 34...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:In this report we show the chromosomal changes seen in a group of 303 Mexican patients with de novo Acute Myeloblastic Leukemia (AML). Two hundred forty-two patients were diagnosed and treated at two hospitals affiliated with the Instituto Mexicano del Seguro Social (IMSS). These are the Centro Medico Nacional Siglo X...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:Three exoglucanase genes have been described in Saccharomyces cerevisiae. The bulk of the exoglucanase (EXO) activity is encoded by the EXG1 gene, whose primary gene product is differentially glycosylated during its transit to the cell surface to yield three isoenzymes: EXOI, EXOII and EXOII1/2. EXOII, the major isoen...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：
更新日期：1993-10-01 00:00:00
abstract：:Classical descriptions of the pathology of amebiasis portray the parasite as the cause of tissue damage and destruction, and in recent years a number of amebic molecules have been identified as virulence factors. In this review we describe a series of experiments that suggest a more complex host-parasite relation, at ...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2005.10.007
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:It has been recently shown that oral administration of D002, a mixture of higher aliphatic primary alcohols isolated from beeswax, inhibits rat microsomal lipid peroxidation. This justified the present attempt to investigate whether D002 also exerts antioxidant effects in humans. METHODS:The effects of D002...
journal_title：Archives of medical research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0188-4409(01)00315-0
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND AND AIMS:In Brazil, sickle cell anemia (SCA) is one of the most common genetic disorders. The levels of fetal hemoglobin (HbF) may be influenced by the presence of genetic modifiers; among these are the β(S)-globin haplotypes, associated with the clinical heterogeneity presented by the disease. Patients with...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2012.08.014
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Psychiatrists may be at an increased risk of suicide, since they encounter stressful factors in their everyday activities in addition to the sociodemographic factors for suicidal ideation reported for Mexican population. AIM OF THE STUDY:To determine whether experiences inherent to the profession were relat...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2019.11.010
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Urinalysis is one of the most common studies performed on the diabetic patient at every visit. The presence of leukocyturia is relatively common but it is not clear what the attitude of the physician toward this particular finding should be. The main objective of the present study was to investigate the clin...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(00)00072-2
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND AND AIMS:Small cell lung cancer (SCLC) is frequently associated with syndrome of inappropriate antidiuretic hormone (SIADH) secretion. In this study we investigated the prognostic value of SIADH in Chinese patients with SCLC. METHODS:We prospectively studied a total of 385 patients with SCLC diagnosed in ou...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2015.12.006
更新日期：2016-01-01 00:00:00
abstract：:In this study we evaluated the usefulness of ferruginous bodies (FB) quantification in lung digest and histologic sections from 40 patients with a history of exposure to inorganic dusts. The patients were matched with 40 cases without occupational exposure. The samples of peripheral lung tissue were digested and all F...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:This study investigated the association of working conditions and lifestyle with the development of increased serum gamma-glutamyltransferase (GGT) in Japanese workers. METHODS:A follow-up study was carried out on workers of a telecommunication enterprise who received their first annual health check-up betw...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.03.027
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Estrogens exert profound effects on target tissues. These effects are mediated by two estrogen receptors (ER(alpha) and ER(beta)) that bind to specific DNA sequences in estrogen-dependent genes. Other molecules such as growth factors, transcription factors and some oncoproteins might interact with the estrog...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.03.030
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:We assessed the auditory function of 94 patients with type 2 diabetes mellitus and 94 age- and sex-matched healthy subjects. METHODS:To study the influence of the clinical characteristics of the disease on the auditory function, after a clinical interview with ophthalmological assessment, subjects were eval...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2005.02.002
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND AND AIMS:Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive oxygen radical species are involved with the pathophysiology of cisplatin-induced hepatotoxicity. Molsidomine (MOL) can exert antioxidant an...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2013.09.013
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:The benefits of a special stroke care unit (SSCU) over a non-specialized stroke care unit (NSSCU) is well documented in the literature. However, there are concerns that the benefits seen in the SSCU do not consider clinical risk factors that affect thrombolysis therapy. METHOD:Retrospective data were collec...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2019.01.002
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:The J wave has been seen in idiopathic ventricular fibrillation, Brugada syndrome, and early repolarization syndrome. Although these conditions share some ECG features, the clinical consequences are markedly different. J wave presentation in healthy subjects is not a rare phenomenon, although its characteris...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2007.08.006
更新日期：2008-02-01 00:00:00
abstract：:High-risk-type human papillomavirus DNA sequences are found in a high percentage of carcinomas from the uterine-cervix, with the viral E1-E2 gene region usually disrupted and the E6 and E7 oncoproteins consistently expressed. The E2 protein is known to repress early transcription from genital HPV promoters having a pr...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Umbilical cord blood (UCB) has been identified as a good source of hematopoietic and nonhematopoietic stem cells that can be easily isolated. In the present study we investigated the possibility of whether stem cells in mononuclear UCB grown under defined conditions can produce progeny with neural p...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2011.10.003
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:A recent revelation about increased susceptibility to HIV by use of nonoxynol-9 (N-9) has called for identification of novel molecules with potent sperm-attenuating activity and lower side-effect profile, as suitable alternatives. The present study was designed to investigate spermicidal activity in Bohadsch...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2008.06.007
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to determine whether newborn birth weights were associated with insulin-like growth factor I (IGF-I), zinc, and leptin in preeclamptic and normotensive pregnancies. METHODS:This study was done cross-sectionally and included 15 women with moderate preeclampsia (PE group) and ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/s0188-4409(01)00364-2
更新日期：2002-01-01 00:00:00
abstract：:It is likely that monosodium glutamate (MSG) is the excitotoxin that has been most commonly employed to characterize the process of excitotoxicity and to improve understanding of the ways that this process is related to several pathological conditions of the central nervous system. Excitotoxicity triggered by neonatal...
journal_title：Archives of medical research
pub_type： 杂志文章,评审
doi：10.1016/j.arcmed.2014.11.014
更新日期：2014-11-01 00:00:00
abstract：OBJECT:Astragaloside IV (AS IV) has antioxidative and anti-apoptotic properties, however, its effects on juvenile mice with diabetic ketoacidosis (DKA) have not been determined. This study aims to explore the effect and mechanism of Astragaloside IV (AS-IV) on juvenile mice with DKA. METHODS:DKA model was established ...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2020.06.013
更新日期：2020-10-01 00:00:00
abstract：AIMS:To explore the effect of salvianolic acid B (Sal B) on regulation of SIRT3/FOXO1 signaling pathway in rats with non-alcoholic steatohepatitis (NASH). METHODS:Sixty Sprague Dawley (SD) rats were randomly divided into control, model and treatment groups. After 12 weeks of successful model establishment with high fa...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2017.11.016
更新日期：2017-08-01 00:00:00
