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Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia.

Abstract：

OBJECTIVES:Anthracyclines and cytarabine are cornerstones for intensive chemotherapy in acute myeloid leukemia (AML). The goals of this study were to comprehensively assess deviations from theoretical doses and the impact of body-surface area (BSA) on patients' characteristics, physicians' strategy, dose adjustment, and clinical outcome. METHODS:The GOELAMS 2001 phase III trial included 823 AML patients below 60 years of age. In the course of treatment, anthropomorphic parameters and chemotherapy doses were prospectively registered. RESULTS:Very high BSA (≥2.15 m2 ) was the factor most significantly associated with the physician's decision to reduce chemotherapy doses during induction and postremission therapy. Despite similar AML characteristics and therapeutic strategies, the very high BSA group exhibited a significantly worse survival (5-years OS of 27%) compared to the low (BSA≤1.5 m2 ), intermediate (1.5 m2

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Cahu X,Carré M,Recher C,Pigneux A,Hunault-Berger M,Vey N,Chevallier P,Delaunay J,Gyan E,Lioure B,Bonmati C,Himberlin C,Hicheri Y,Guillerm G,Didier B,Larosa F,Ojeda-Uribe M,Bernard M,Bene MC,Ifrah N,Cahn JY

doi

10.1111/ejh.12850

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

443-449

issue

5

eissn

0902-4441

issn

1600-0609

journal_volume

98

pub_type

杂志文章

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