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Assessment of the value of treatment with granulocyte colony-stimulating factor in children with acute lymphoblastic leukemia: a randomized clinical trial.

Abstract：

:The present trial was designed to test the effects of G-CSF on the duration of the second phase of induction chemotherapy in children with newly diagnosed acute lymphoblastic leukemia (ALL). A total of 32 patients were assigned randomly to a group that received (14 patients; group A) or a group that did not receive (18 patients; group B) G-CSF (10 g/kg/day subcutaneously and daily) throughout of the second phase of induction therapy. One of 14 (7.1%) patients in group A and 2 of 18 (11.1%) patients in group B completed the course of chemotherapy within the planned time. The median length of this phase was 37 days (range, 29 to 65; mean, 40; SD, 8.6) for patients in group A and 36 days (range, from 29 to 55; mean, 38; SD, 7.4) for those in group B, and the difference was not statistically significant. The number of days during which patients had granulocyte counts of less than 2 x 10(9)/l, the number of febrile episodes of unknown origin, the number of bacterial and fungal infections and the number of days of hospitalization did not differ in a statistically significant manner between the two groups. Our data suggest that G-CSF supportive therapy may be unnecessary in children with neutropenia of short duration, for whom the risk of infection is low.

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Dibenedetto SP,Ragusa R,Ippolito AM,Lo Nigro L,Di Cataldo A,D'Amico S,Miraglia V

doi

10.1111/j.1600-0609.1995.tb01816.x

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

93-6

issue

2

eissn

0902-4441

issn

1600-0609

journal_volume

55

pub_type

临床试验,杂志文章,随机对照试验

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