FDA's and EMA's approval of brentuximab vedotin for advanced Hodgkin lymphoma: Another player in the town?

Abstract:

:ECHELON-1 study is a randomized open-labeled controlled trial investigating whether addition of brentuximab vedotin to chemotherapy offers benefit over the standard chemotherapy regimen in advanced Hodgkin lymphoma. After a median follow-up of 24.6 months, it has met its primary endpoint the reduction of modified progression-free survival being 23 percent. However, the beneficial effects have not been seen across all subgroups leading to further questions. The main aim of this review is to tackle these questions to provide the reader with in-depth insight of pros and cons of this novel, promising but ultimately controversial regimen.

journal_name

Eur J Haematol

authors

Milunović V,Mišura Jakobac K,Kursar M,Mandac Rogulj I,Ostojić Kolonić S

doi

10.1111/ejh.13269

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

145-151

issue

3

eissn

0902-4441

issn

1600-0609

journal_volume

103

pub_type

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