Venlafaxine-induced ecchymoses and impaired platelet aggregation.

abstract：:Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the co...

journal_title：European journal of haematology

authors： Tsutsumi Y,Tanaka J,Kanamori H,Musashi M,Minami H,Fukushima A,Yamato H,Ehira N,Kawamura T,Obara S,Ogura N,Asaka M,Imamura M,Masauzi N

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:Chimeric antigen receptor (CAR) T cells targeting B cell maturation antigen (BCMA) have shown impressive results in clinical studies for relapsed/refractory multiple myeloma (RRMM). We performed a systematic literature review to summarize the current body of evidence on the role of anti-BCMA CAR T cells fo...

journal_title：European journal of haematology

authors： Gagelmann N,Ayuk F,Atanackovic D,Kröger N

更新日期：2020-04-01 00:00:00

abstract：:Forty-six consecutive patients with acute lymphoblastic leukaemia (ALL), having a median age of 23 years (range 14 to 64), underwent induction and consolidation chemotherapy with weekly parenteral vincristine, adriamycin, l-asparaginase and daily oral prednisone (VAAP), followed by standard central nervous system (CNS...

journal_title：European journal of haematology

authors： Jacobs P,Wood L

更新日期：1992-08-01 00:00:00

abstract：:The European LeukemiaNet (ELN) is composed of several work packages, four of them being directly involved in the various aspects of diagnosis. On the occasion of the annual ELN meeting of 2015 in Mannheim, these four work packages collectively examined the current situation and future prospects of cytomorphology, flow...

journal_title：European journal of haematology

authors： Béné MC,Grimwade D,Haferlach C,Haferlach T,Zini G,European LeukemiaNet.

更新日期：2015-10-01 00:00:00

abstract：:506 unselected, previously untreated patients with Hodgkin's disease were treated at the Finsen Institute between 1969 and 1983. The prognostic significance of age, sex, stage, systemic symptoms, histologic subtype, number of involved nodal regions, total tumour burden (peripheral + intrathoracic nodal tumour burden, ...

journal_title：European journal of haematology

authors： Specht L,Nissen NI

更新日期：1989-08-01 00:00:00

abstract：:15 cases of acute leukemia (AL) displaying a TdT+, HLA-DR+ phenotype were studied; surface immunoglobulins, T cell markers and the common acute lymphoblastic leukaemia (c-ALL) antigen were negative, as were peroxidase and non-specific esterase cytochemical reactions. All cases were extensively investigated by conventi...

journal_title：European journal of haematology

authors： Basso G,Putti MC,Catoretti G,Consolini R,Galdiolo D,Guglielmi C,Messina C,Milanesi C,Testi AM,Xillo MZ

更新日期：1987-02-01 00:00:00

abstract：:Eighteen patients with malignant lymphoma, 10 non-Hodgkin's and 8 Hodgkin's, were treated with high-dose CVB (cyclophosphamide 4 x 1.5 g/m2, etoposide 4 x 250-400 mg/m2, carmustine 4 x 150-200 mg/m2), followed by autologous peripheral blood stem cells (PBSC, 13 patients) or bone marrow (BM, 5 patients) transplantation...

journal_title：European journal of haematology

authors： Patti C,Majolino I,Scimè R,Indovina A,Vasta S,Liberti G,Gentile S,Santoro A,Pisa R,Caronia F

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:Mantle cell lymphoma (MCL) is an incurable disease with an aggressive course and novel treatment strategies are urgently needed. The purpose of this study was to evaluate the effects of histone deacetylase (HDAC) inhibitors, a new group of antiproliferative agents, on human MCL cells. METHODS:Three MCL cell...

journal_title：European journal of haematology

authors： Heider U,Kaiser M,Sterz J,Zavrski I,Jakob C,Fleissner C,Eucker J,Possinger K,Sezer O

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:To assess the molecular basis of phenotypic heterogeneity in north Indian patients with thalassemia major (TM). METHODS:To determine the clinical severity, 130 patients of TM were studied for the age of first presentation and frequency of blood transfusion. The type of beta mutations, Xmn-1(G)gamma polymorp...

journal_title：European journal of haematology

authors： Sharma N,Das R,Kaur J,Ahluwalia J,Trehan A,Bansal D,Panigrahi I,Marwaha RK

更新日期：2010-06-01 00:00:00

abstract：:Myeloproliferative neoplasms associated with FIP1L1-PDGFR rearrangements represent a rare subset of myeloid and lymphoid malignancies, characterised by the presence of eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 genes. The fusion product of such genes is a tyrosine kinase oncoprotein sensitive to imatini...

journal_title：European journal of haematology

authors： Barraco D,Carobolante F,Candoni A,Simeone E,Piccaluga P,Tabanelli V,Fanin R

更新日期：2014-06-01 00:00:00

abstract：:Severe iron overload is frequent in dehydrated hereditary stomatocytosis (DHSt) despite well-compensated hemolysis and no or little transfusion requirement. We investigated 4 patients with proven DHSt, in whom the degree of hemolysis was closely related to iron status. Genetic modifiers increasing iron stores (HFE:pCy...

journal_title：European journal of haematology

authors： Orvain C,Da Costa L,Van Wijk R,Pissard S,Picard V,Mansour-Hendili L,Cunat S,Giansily-Blaizot M,Cartron G,Schved JF,Aguilar-Martinez P

更新日期：2018-10-01 00:00:00

abstract：UNLABELLED:Historically, treatment of invasive fungal infections (IFI) has consisted of amphotericin B. However, new therapeutic agents have recently been introduced. At the same time, the relatively low incidence of IFI and the progress in the diagnostic accuracy of IFI have made routine use of empirical antifungal th...

journal_title：European journal of haematology

authors： Cherif H,Kalin M,Björkholm M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES AND METHODS:We conducted a retrospective analysis to evaluate the outcomes of 28 heavily pretreated (median 3 (2-6) treatment lines, sixteen (57%) allotransplanted) relapsed/refractory acute myeloid leukemia patients who had failed salvage venetoclax-based therapies. RESULTS:The median age was 59 years (20-...

journal_title：European journal of haematology

authors： Zucenka A,Pileckyte R,Trociukas I,Peceliunas V,Vaitekenaite V,Maneikis K,Davainis L,Zvirblis T,Stoskus M,Gineikiene E,Norvilas R,Dirse V,Surauciute A,Zucenkiene E,Griskevicius L

更新日期：2021-01-01 00:00:00

abstract：:We tested the immunosuppressive effect of cord blood (CB) natural killer (NK) cells using highly purified CB NK cells in mixed lymphocyte cultures (MLC) containing autologous CB T cells as responders. Control cultures were done without NK cells. Our findings revealed that CB NK cells induced a dose-dependent inhibitio...

journal_title：European journal of haematology

authors： El Marsafy S,Dosquet C,Coudert MC,Bensussan A,Carosella E,Gluckman E

更新日期：2001-04-01 00:00:00

abstract：:Steroid-refractory graft-versus-host disease (GvHD) is a complication following an allogeneic stem cell transplantation with limited therapeutic options. Studies have shown a response in up to 80% of patients with this condition after treatment with the CD25 monoclonal antibody, basiliximab. Despite the good responses...

journal_title：European journal of haematology

authors： Chakupurakal G,García-Márquez MA,Shimabukuro-Vornhagen A,Theurich S,Holtick U,Hallek M,Scheid C,von Bergwelt-Baildon M

更新日期：2016-08-01 00:00:00

abstract：:In 18 beta-thalassaemia families from the Ferrara area the incidence of an inherited low flavin mononucleotide (FMN)-dependent pyridoxine phosphate (PNP) oxidase activity, a sensitive indicator of red-cell FMN deficiency, is higher in related members in these families than in the unrelated spouses and controls subject...

journal_title：European journal of haematology

authors： Anderson BB,Perry GM,Clements JE,Studds C,Fashola R,Salsini G,Vullo C

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVES:Here, we tested the hypothesis that human M-CSF (hM-CSF) overexpressed in cord blood (CB) CD34+ cells would induce differentiation and survival of monocytes and osteoclasts in vitro and in vivo. METHODS:Human M-CSF was overexpressed in cord blood CD34+ cells using a lentiviral vector. RESULTS:We show that ...

journal_title：European journal of haematology

authors： Montano Almendras CP,Thudium CS,Löfvall H,Moscatelli I,Schambach A,Henriksen K,Richter J

更新日期：2017-05-01 00:00:00

abstract：:Several reports of successful empirical treatment of idiopathic hypereosinophilic syndrome with imatinib led to the recent identification of the FIP1L1-PDGFRA fusion gene rearrangement, which characterizes a distinctive group of chronic eosinophilic leukemias. This fusion gene can be detected in eosinophils, neutrophi...

journal_title：European journal of haematology

authors： Capovilla M,Cayuela JM,Bilhou-Nabera C,Gardin C,Letestu R,Baran-Marzak F,Fenaux P,Martin A

更新日期：2008-01-01 00:00:00

abstract：:Immune thrombocytopenic purpura (ITP) is an autoimmune disorder, and high-dose dexamethasome (HD-DXM) has been used as a first-line therapy for patients with ITP. However, little is known about the role of dendritic cells (DCs) and CD4(+)Foxp3(+) regulatory T (Treg) cells in the pathogenesis of chronic ITP and the eff...

journal_title：European journal of haematology

authors： Ling Y,Cao X,Yu Z,Ruan C

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Interferon-alpha (IFNalpha) was the first effective pharmacologic treatment of hairy cell leukemia (HCL). Since 1990 purine analogs replaced IFNalpha because of higher rates of complete remission and an invariable disease recurrence after cessation of IFNalpha. However, there are only limited data about long-...

journal_title：European journal of haematology

authors： Benz R,Siciliano RD,Stussi G,Fehr J

更新日期：2009-03-01 00:00:00

abstract：:Marrow fibroblast colony formation was studied in patients with myeloproliferative disorders, using human serum or platelet-derived growth factor plus plasma-derived serum as growth-stimulating factors. Colony numbers negatively correlated with the patient's age, but were not different from those of controls. However,...

journal_title：European journal of haematology

authors： Kimura A,Katoh O,Hyodo H,Kusumi S,Kuramoto A

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVES:Overexpression of FK506 binding protein 51 (FKBP51) in megakaryocytic progenitor cells generated from purified CD34+ cells in patients with idiopathic myelofibrosis (IMF) has been demonstrated. It has been suggested that FKBP51 is involved in the dysregulation of the apoptotic programme with consecutive prol...

journal_title：European journal of haematology

authors： Bock O,Neusch M,Büsche G,Mengel M,Kreipe H

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to compare the major transplant outcomes between patients receiving hematopoietic stem cell transplantation (HSCT) from bone marrow (BM) or peripheral blood stem cells (PBSC). METHODS:All consecutive HSCT patients using BM or PBSC from an HLA-matched related donors for haemat...

journal_title：European journal of haematology

authors： Campregher PV,Hamerschlak N,Colturato VA,Mauad MA,de Souza MP,Bouzas LF,Tavares Rde C,Barros JC,Chiattone R,Paz A,Silla L,Vigorito AC,Miranda E,Funke VA,Flowers ME

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The single nucleotide polymorphism SNP309 with a change from T to G in the promoter region of the MDM2 gene is shown to increase the MDM2 protein levels and attenuate the p53 levels and associates with disease progression in several tumors. OBJECTIVE:In this study, the role of the polymorphism was investiga...

journal_title：European journal of haematology

authors： Willander K,Ungerbäck J,Karlsson K,Fredrikson M,Söderkvist P,Linderholm M

更新日期：2010-09-01 00:00:00

abstract：:Administration of both glycosylated and non-glycosylated recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) induces an immediate transient granulocytopenia of 1-3 hours' duration. In order to explore this phenomenon, granulocytes were labelled with 111Indium and the effect on the kinetics of...

journal_title：European journal of haematology

authors： Hovgaard D,Schifter S,Rabøl A,Mortensen BT,Nissen NI

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:The mutational status of the immunoglobulin (Ig) V(H) gene in B-cell chronic lymphocytic leukaemia (B-CLL) identifies two subgroups of patients with significantly different outcomes. We investigated the association of ZAP-70 expression with IgVH mutational status in B-CLL by quantifying ZAP-70 mRNA, to evalua...

journal_title：European journal of haematology

authors： Catherwood MA,Matthews C,Niblock R,Dobbin E,Morris TC,Alexander HD

更新日期：2006-04-01 00:00:00

abstract：:As a component of the MRN complex (which is a heterotrimeric protein complex consisting of MRE11, RAD50 and NBS1), NBS1 plays an important role in cellular response to DNA damage and the maintenance of chromosomal integrity. Leukemia is common in NBS1 germ line-mutated patients. The NBS1 E185Q polymorphism (8360G>C, r...

journal_title：European journal of haematology

authors： Jiang L,Liang J,Jiang M,Yu X,Zheng J,Liu H,Wu D,Zhou Y

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The clinical severity in thalassaemia major (TM) depends on the underlying mutations of the beta-globin gene and the degree of iron overload. OBJECTIVE:The aim of the study was to investigate the impact of genotype on the development of endocrine complications in TM in our center. SUBJECTS AND METHODS:126 ...

journal_title：European journal of haematology

authors： Skordis N,Michaelidou M,Savva SC,Ioannou Y,Rousounides A,Kleanthous M,Skordos G,Christou S

更新日期：2006-08-01 00:00:00

abstract：:An intensive protocol utilizing mitoxantrone, high-dose cytarabine, vincristine, etoposide and methylprednisolone as induction therapy for chronic myeloid leukemia in blast transformation is described. Fourteen patients were treated, with a remission/second chronic phase achieved in 64%. None of the 3 patients older t...

journal_title：European journal of haematology

authors： Lipton JH,Messner HA,Curtis JE,Atkins HL,Minden MD

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVES:MicroRNAs (miRNAs) play key roles in a wide variety of normal and pathological cellular processes. A number of studies identified hematopoietic-specific miRNAs that are necessary for correct function of blood cells. Out of our microarray data, we chose 13 miRNAs that showed differential expression in periphe...

journal_title：European journal of haematology

authors： Merkerova M,Belickova M,Bruchova H

更新日期：2008-10-01 00:00:00