Effectiveness of propagermanium treatment in multiple myeloma patients.

abstract：OBJECTIVE:The primary objective was to assess the effect of central nervous system involvement in acute myeloid leukemia (CNS-AML) on outcomes after allogeneic hematopoietic stem cell transplant (allo-HCT). The secondary objective was to assess the utility of pretransplant cerebrospinal fluid (CSF) assessment in AML. ...

journal_title：European journal of haematology

authors： Prem S,Atenafu EG,Avena J,Bautista R,Law A,Lam W,Michelis FV,Kim DDH,Viswabandya A,Lipton JH,Mattsson J,Kumar R

更新日期：2019-11-01 00:00:00

abstract：:In March 1981, a 53-year-old man presented with itching and was diagnosed as having myelofibrosis. There was gradual enlargement of the spleen over the following 5 yr. His spleen had to be removed in February 1986 because of physical discomfort. 3 months post-splenectomy he became polycythaemic. Bone marrow examinatio...

journal_title：European journal of haematology

authors： Dokal I,Pagliuca A,Deenmamode M,Mufti GJ,Lewis SM

更新日期：1989-01-01 00:00:00

abstract：:BLyS and APRIL share two receptors - transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B-cell maturation antigen (BCMA) - and BLyS binds to a third receptor, BAFF-R. We previously reported that TACI gene expression is a good indicator of a BLyS-binding receptor in human multipl...

journal_title：European journal of haematology

authors： Moreaux J,Sprynski AC,Dillon SR,Mahtouk K,Jourdan M,Ythier A,Moine P,Robert N,Jourdan E,Rossi JF,Klein B

更新日期：2009-08-01 00:00:00

abstract：:The effect of human recombinant interferon alpha 2 (IFN alpha 2) on hairy cells obtained from 16 patients was evaluated. All patients promptly responded to induction of remission with 2 X 10(6) U/m2 interferon alpha 2 b, three times a week, sc. In order to achieve a more detailed insight into the mode of action of int...

journal_title：European journal of haematology

authors： Schwarzmeier JD,Schwabe M,Prischl F,Wagner L,Lion T,Micksche M,Köller U

更新日期：1987-11-01 00:00:00

abstract：:Cardiac disease is the primary cause of mortality in beta-thalassemia patients. Except for ventricular dysfunction and pulmonary hypertension that represent the main forms of heart disease in these patients, valvular abnormalities including valvular regurgitation, endocardial thickening and calcification and mitral va...

journal_title：European journal of haematology

authors： Farmakis D,Deftereos S,Giakoumis A,Polymeropoulos E,Aessopos A

更新日期：2004-04-01 00:00:00

abstract：:We analyzed the expression of the inhibitor of apoptosis survivin by immunocytochemistry in bone marrow cells from patients with chronic myelomonocytic leukemia (CMML) to evaluate possible abnormalities in comparison with other myelodysplastic (MDS) and myeloproliferative syndromes, and to investigate a possible corre...

journal_title：European journal of haematology

authors： Invernizzi R,Travaglino E,Benatti C,Malcovati L,Della Porta M,Cazzola M,Ascari E

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVES:Homoharringtonine (HHT) was efficient in therapying patients with acute myeloid leukemia (AML) in China, but little is known about the mechanism of its action. As the abnormal activation of JAK2 associated pathway is important to AML, we try to explore the effect of HHT on JAK2-STAT pathway in AML cells, thu...

journal_title：European journal of haematology

authors： Tong H,Ren Y,Zhang F,Jin J

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate serum leptin levels in idiopathic thrombocytopenic purpura (ITP), in order to determine the influence of leptin on the pathogenesis of ITP. SUBJECTS AND METHODS:Forty-six untreated patients with chronic ITP were compared with 40 healthy people of similar age, sex an...

journal_title：European journal of haematology

authors： Zhan M,Zhao H,Yang R,Han ZC

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Patients with hematologic malignancies are at substantial risk of developing invasive fungal infections (IFI) that are associated with substantial morbidity and mortality. This article reviews the epidemiology, risk factors, and efficacy of antifungal prophylaxis in patients with hematologic malignancies. ME...

journal_title：European journal of haematology

authors： Maertens J

更新日期：2007-04-01 00:00:00

abstract：:The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these...

journal_title：European journal of haematology

authors： Guimarães JS,Cominal JG,Silva-Pinto AC,Olbina G,Ginzburg YZ,Nandi V,Westerman M,Rivella S,de Souza AM

更新日期：2015-06-01 00:00:00

abstract：:Thirty-four patients with myelodysplastic syndromes, 23 men and 11 women, aged between 47 and 80 years, with all types of myelodysplastic syndromes were treated with 13-cis-retinoic acid. The dose of retinoic acid ranged between 10 and 60 mg/m2/daily and was administered in combination with vitamin E to diminish side ...

journal_title：European journal of haematology

authors： Bourantas KL,Tsiara S,Christou L

更新日期：1995-10-01 00:00:00

abstract：:We are reporting here the results of differential gene expression experiments comparing two siblings, a 21-yr-old male and a 19-yr-old female, with the same alpha-thalassemia genotype (-alpha(3.7)/(--SEA)) and quite different levels of Hb H in the peripheral blood (18.7 and 5%, respectively). By using mRNA differentia...

journal_title：European journal of haematology

authors： Wenning MR,Mello MP,Andrade TG,Lanaro C,Albuquerque DM,Saad ST,Costa FF,Sonati MF

更新日期：2009-11-01 00:00:00

abstract：:We serially determined serum erythropoietin (Epo) and the reticulocyte count in patients with various types of leukemia during chemotherapy. Serum Epo increased soon after the initiation of chemotherapy and decreased after the termination of therapy irrespective of the types of leukemia or treatment regimen. However, ...

journal_title：European journal of haematology

authors： Sawabe Y,Kikuno K,Iseki T,Lida S,Tabata Y,Yonemitsu H

更新日期：1996-11-01 00:00:00

abstract：INTRODUCTION:Symptomology of AL amyloidosis can be vague, with a broad range of manifestations and potential etiologies. We sought to determine whether time from initial patient-reported symptom onset to diagnosis was associated with survival. METHODS:The Boston University Amyloidosis Patient Database was queried for ...

journal_title：European journal of haematology

authors： Schulman A,Connors LH,Weinberg J,Mendelson LM,Joshi T,Shelton AC,Sanchorawala V

更新日期：2020-10-01 00:00:00

abstract：:We generated a 100-kb map of the region 5' of the PML (promyelocytic leukemia) gene on human chromosome 15q22 and identified a new gene provisionally named STORP for stomatin-related protein. The STORP gene is positioned 2 kb upstream of the PML gene in a head-to-head configuration, and contains 7 exons spanning a gen...

journal_title：European journal of haematology

authors： Gilles F,Glenn M,Goy A,Remache Y,Zelenetz AD

更新日期：2000-02-01 00:00:00

abstract：:It has been recently demonstrated that ecto-5'nucleotidase (5'NT) activity is significantly decreased in the peripheral blood lymphocytes (PBL) of homosexual men. This paper reports a study of PBL 5'NT activity in 38 hemophiliacs at risk for the acquired immunodeficiency syndrome (AIDS). The enzyme activity was correl...

journal_title：European journal of haematology

authors： Massaia M,Pioppo P,Dianzani U,Guerra MG,Peyretti F,Pileri A,Tamponi G

更新日期：1987-04-01 00:00:00

abstract：:Cytosine arabinoside (ara-C) and etoposide are often used in combination in the treatment of acute myelocytic leukemia (AML). The intracellular phosphorylation of ara-C to its 5'-triphosphate (ara-CTP) is a prerequisite for its cytotoxic effects. It has been shown in vitro that etoposide can impair the formation of ar...

journal_title：European journal of haematology

authors： Liliemark J,Knochenhauer E,Gruber A,Pettersson B,Björkholm M,Peterson C

更新日期：1993-01-01 00:00:00

abstract：:MALT lymphoma is usually described in association with Helicobacter pylori, HCV, HHV8, Campylobacter jejuni or in a setting of overreactive immunity. In HIV(+) patients, MALT lymphoma is most commonly described in children. We describe here an original case of HIV(+) MALT lymphoma with bronchial, conjuctival and laryn...

journal_title：European journal of haematology

authors： Girard T,Luquet-Besson I,Baran-Marszak F,Raphaël M,Boué F

更新日期：2005-01-01 00:00:00

abstract：AIM:This review summarises the importance, recent progress and issues in measuring patient-reported outcomes (PROs) in haemophilia research. METHODS:A critical review of recent advances and trends in measuring haemophilia-related PROs was conducted, using current regulatory guidelines and methodological recommendation...

journal_title：European journal of haematology

authors： Pocoski J,Benjamin K,Michaels LA,Flood E,Sasane R

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To correlate different polymorphisms of the beta-globin cluster with fetal hemoglobin (HbF) level in beta-thalassemia and E-beta thalassemia patients. METHODS:Fifteen thalassemia patients, seven with high HbF and not requiring transfusion, eight with lower HbF and requiring transfusion were studied for beta-...

journal_title：European journal of haematology

authors： Bandyopadhyay S,Mondal BC,Sarkar P,Chandra S,Das MK,Dasgupta UB

更新日期：2005-07-01 00:00:00

abstract：:The new World Health Organization (WHO) classification of hematologic malignancies has incorporated t(8;21) myelodysplastic syndromes (MDS) according to the French-American-British classification into the category of acute myeloid leukemia (AML) with t(8;21)(q22;q22), while our knowledge about clinicopathological feat...

journal_title：European journal of haematology

authors： Kaneda K,Kojima K,Takeuchi M,Takimoto H,Takaba S,Shinagawa K,Kobayashi H,Miyata A,Hara M,Tanimoto M

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Wnt signaling induces a plethora of intracellular responses that dictate normal or abnormal cellular behavior. Abnormal WNT signaling has been related to the development of leukemogenic processes. In this regard, it is important to know the expression profile of WNT receptors in normal and malignant cells, i...

journal_title：European journal of haematology

authors： Alvarez-Zavala M,Riveros-Magaña AR,García-Castro B,Barrera-Chairez E,Rubio-Jurado B,Garcés-Ruíz OM,Ramos-Solano M,Aguilar-Lemarroy A,Jave-Suarez LF

更新日期：2016-08-01 00:00:00

abstract：:Over the last two decades, the role of microRNAs has been extensively investigated, and it has become clear that these small non-coding RNAs play an essential role in several biological processes including erythropoiesis and that their dysregulation is associated with pathologies. Recent technical innovations have con...

journal_title：European journal of haematology

authors： Azzouzi I,Schmugge M,Speer O

更新日期：2012-07-01 00:00:00

abstract：:Patients with essential thrombocythemia (ET) often suffer from neurological symptoms (NS) not ever resulting from previous thrombotic cerebral events (TCE). We reported NS occurred in 282 patients, in order to identify the factors influencing ET-related NS in the absence of TCE, and the response to therapy. Overall, 1...

journal_title：European journal of haematology

authors： Aroldi A,Cecchetti C,Colombo A,Cattaneo L,Pioltelli PE,Pogliani EM,Elli EM

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the kinetics of molecular response in chronic myeloid leukemia (CML) patients treated with imatinib and to compare between the fluorescent in situ hybridization (FISH), multiplex and real-time quantitative RT-PCR (RQ-PCR) methods with this respect. METHODS:Molecula...

journal_title：European journal of haematology

authors： Raanani P,Ben-Bassat I,Gan S,Trakhtenbrot L,Mark Z,Ashur-Fabian O,Itskovich S,Brok-Simoni F,Rechavi G,Amariglio N,Nagler A

更新日期：2004-10-01 00:00:00

abstract：:Bcl-2 expression, the number of apoptotic cells and the growth and differentiation of early bone marrow progenitor cells were studied in patients with confirmed diagnosis of acute myeloid leukaemia (AML). Bone marrow cells from normal individuals were used as controls. We observed an increased percentage of bcl-2-mono...

journal_title：European journal of haematology

authors： Bincoletto C,Saad ST,da Silva ES,Queiroz ML

更新日期：1999-01-01 00:00:00

abstract：:The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic ris...

journal_title：European journal of haematology

authors： Purdy JC,Shatzel JJ

更新日期：2020-12-03 00:00:00

abstract：OBJECTIVE:Myelodysplastic syndromes (MDS) and aplastic anemia (AA) are the most common anemias that require transfusion therapy in Japan. This retrospective survey investigated relationships between iron overload, chelation practices, and morbidity/mortality in patients with these diseases. METHOD:Medical histories of...

journal_title：European journal of haematology

authors： Takatoku M,Uchiyama T,Okamoto S,Kanakura Y,Sawada K,Tomonaga M,Nakao S,Nakahata T,Harada M,Murate T,Ozawa K,Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes.

更新日期：2007-06-01 00:00:00

abstract：:In 18 beta-thalassaemia families from the Ferrara area the incidence of an inherited low flavin mononucleotide (FMN)-dependent pyridoxine phosphate (PNP) oxidase activity, a sensitive indicator of red-cell FMN deficiency, is higher in related members in these families than in the unrelated spouses and controls subject...

journal_title：European journal of haematology

authors： Anderson BB,Perry GM,Clements JE,Studds C,Fashola R,Salsini G,Vullo C

更新日期：1989-04-01 00:00:00

abstract：:Skin necrosis caused by heparins is a rare complication. We report a case of a 71-yr-old white woman who developed painful diffuse skin lesions, most probably related to enoxaparin treatment. Other causes of skin necrosis, including heparin induced thrombocytopenia, disseminated intravascular coagulation, protein C/pr...

journal_title：European journal of haematology

authors： Nadir Y,Mazor Y,Reuven B,Sarig G,Brenner B,Krivoy N

更新日期：2006-08-01 00:00:00