Outcomes of relapsed or refractory acute myeloid leukemia patients failing venetoclax-based salvage therapies.

Abstract:

OBJECTIVES AND METHODS:We conducted a retrospective analysis to evaluate the outcomes of 28 heavily pretreated (median 3 (2-6) treatment lines, sixteen (57%) allotransplanted) relapsed/refractory acute myeloid leukemia patients who had failed salvage venetoclax-based therapies. RESULTS:The median age was 59 years (20-80), 20 patients (71%) had ECOG 2-4 status, and 18 patients (64%) were stratified to European Leukemia Network 2017 adverse risk group. The most common mutations were ASXL1 (21%), RUNX1 (18%), FLT3 ITD/TKD (18%), PTPN11 (15%), NRAS/KRAS (15%), and WT1 (15%). Twenty-two patients (79%) received different post-venetoclax salvage therapies with the overall response rate of 23% (complete remission + morphological leukemia-free state). Three of six (50%) patients achieved complete remissions after therapy with venetoclax + actinomycin D ± low-dose cytarabine. The remaining 6 patients did not receive any further salvage treatment mainly due to poor general condition. The median overall survival was 3.9 months for all patients (4.3 for those receiving post-venetoclax salvage vs 1.3 months receiving palliative care alone, P < .001). CONCLUSIONS:Though the remission rate and survival of patients failing venetoclax are poor, a small proportion of these R/R AML patients may still respond to cautious intensification of chemotherapy with venetoclax.

journal_name

Eur J Haematol

authors

Zucenka A,Pileckyte R,Trociukas I,Peceliunas V,Vaitekenaite V,Maneikis K,Davainis L,Zvirblis T,Stoskus M,Gineikiene E,Norvilas R,Dirse V,Surauciute A,Zucenkiene E,Griskevicius L

doi

10.1111/ejh.13527

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

105-113

issue

1

eissn

0902-4441

issn

1600-0609

journal_volume

106

pub_type

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