Chronic lymphocytic leukemia: a retrospective study of 122 cases.

abstract：OBJECTIVES:An aberrant pattern of expression of L-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34+ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). METHODS:In a three-colour flow cytometric assay, we evaluated the expression of L-selectin and ICA...

journal_title：European journal of haematology

authors： Buccisano F,Maurillo L,Tamburini A,Del Poeta G,Del Principe MI,Ammatuna E,Consalvo MI,Campagna S,Ottaviani L,Sarlo C,Renzi D,Faccia S,Fraboni D,Lo Coco F,Amadori S,Venditti A

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Aberrant DNA methylation at CpG islands within promoters is increasingly recognised as a common event in human cancers and has been associated with the silencing of important tumour suppressor genes. Epigenetic therapy using hypomethylating agents has demonstrated clinical effectiveness; the drugs azacitidin...

journal_title：European journal of haematology

authors： Poloni A,Goteri G,Zizzi A,Serrani F,Trappolini S,Costantini B,Mariani M,Olivieri A,Catarini M,Centurioni R,Alesiani F,Giantomassi F,Stramazzotti D,Biagetti S,Alfonsi S,Berardinelli E,Leoni P

更新日期：2013-09-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) characterized by the translocation t(11;14)(q13;q32). This lymphoma exhibits a poor prognosis and remains incurable with standard chemotherapy approaches. Recently, we have shown that a majority of patients with acute-type adult T-cell leuke...

journal_title：European journal of haematology

authors： Liu F,Yoshida N,Suguro M,Kato H,Karube K,Arita K,Yamamoto K,Tsuzuki S,Oshima K,Seto M

更新日期：2013-01-01 00:00:00

abstract：:The aim of the present study was to determine whether angelicin is able to increase the expression of gamma-globin genes in human erythroid cells. Angelicin is structurally related to psoralens, a well-known chemical class of photosensitizers used for their antiproliferative activity in treatment of different skin dis...

journal_title：European journal of haematology

authors： Lampronti I,Bianchi N,Borgatti M,Fibach E,Prus E,Gambari R

更新日期：2003-09-01 00:00:00

abstract：:Paraneoplastic neurologic syndromes may develop in Hodgkin's disease (HD). We describe three young female patients with neurological disorders, not explained by other causes, preceding diagnosis or relapse of HD. The lack of response of the paraneoplastic syndrome to successful treatment of HD among our three patients...

journal_title：European journal of haematology

authors： Maslovsky I,Volchek L,Blumental R,Ducach A,Lugassy G

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:Secondary antibody deficiency (SAD), associated with severe, recurrent or persistent infections, is common in patients with haematological malignancies (HM), but unifying guidance on immunoglobulin replacement therapy (IgRT) in these patients is lacking. We aimed to develop consensus statements for the use o...

journal_title：European journal of haematology

authors： Jolles S,Michallet M,Agostini C,Albert MH,Edgar D,Ria R,Trentin L,Lévy V

更新日期：2021-01-16 00:00:00

abstract：:T-cell lymphoma is an aggressive lymphoma that cannot be cured despite aggressive therapy, including autologous stem cell transplantation. Thalidomide is an immunomodulatory drug with numerous properties that has proven effective in relapsed multiple myeloma and, to a lesser extent, in other hematologic diseases. We r...

journal_title：European journal of haematology

authors： Damaj G,Bouabdallah R,Vey N,Bilger K,Mohty M,Gastaut JA

更新日期：2005-02-01 00:00:00

abstract：:Patients with essential thrombocythemia (ET) often suffer from neurological symptoms (NS) not ever resulting from previous thrombotic cerebral events (TCE). We reported NS occurred in 282 patients, in order to identify the factors influencing ET-related NS in the absence of TCE, and the response to therapy. Overall, 1...

journal_title：European journal of haematology

authors： Aroldi A,Cecchetti C,Colombo A,Cattaneo L,Pioltelli PE,Pogliani EM,Elli EM

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Cell cycle arrest by FOXO transcription factors involves in transcriptional activation of p27(kip1), although the exact mechanism remains unclear. And it has been evidenced that reduced level of p27(kip1) which is frequently occurred in human cancers has been associated with poor prognosis. In this study, our...

journal_title：European journal of haematology

authors： Zhao Y,Fei M,Wang Y,Lu M,Cheng C,Shen A

更新日期：2008-08-01 00:00:00

abstract：:Acute tumour lysis syndrome (ATLS) is a well recognised complication of treatment of a variety of malignant disorders. It commonly occurs in patients with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL) with the administration of combined cytotoxic chemotherapy. It is rarely reported after single-...

journal_title：European journal of haematology

authors： Duzova A,Cetin M,Gümrük F,Yetgin S

更新日期：2001-06-01 00:00:00

abstract：:The β⁰-thalassemia/Hb-E causes a wide range of severe conditions. A high medical cost is incurred in severe cases. Thus, the prevention of new cases of β⁰-thalassemia/Hb-E is required. The aim of this study is to use the SYTO9 and SYBR GREEN1 high-resolution melting (HRM) analysis for prenatal diagnosis of β⁰-thalasse...

journal_title：European journal of haematology

authors： Pornprasert S,Sukunthamala K

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Levels of the angiogenic cytokines placental growth factor (PlGF) and soluble Fms-like tyrosine kinase-1 (sFlt-1) and the angiogenic balance, expressed by sFlt-1/PlGF ratio, are perturbed in sickle-cell disease and iron overload, but they have not been evaluated in non-transfusion-dependent thalassemia (NTDT...

journal_title：European journal of haematology

authors： Kelaidi C,Kattamis A,Apostolakou F,Poziopoulos C,Lazaropoulou C,Delaporta P,Kanavaki I,Papassotiriou I

更新日期：2018-06-01 00:00:00

abstract：:This study was conducted in order to assess myocardial and liver iron concentrations (LICs) using serial magnetic resonance imaging (MRI) scans in patients with beta-thalassaemia major, over a 4-yr period, and consequently to compare the effectiveness of different chelation regimens. Fifty children and young adults wi...

journal_title：European journal of haematology

authors： Christoforidis A,Haritandi A,Tsatra I,Tsitourides I,Karyda S,Athanassiou-Metaxa M

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:A retrospective study was performed to explore the effect of splenectomy on iron balance in thalassemia major (TM). METHODS:Twenty two TM patients treated with splenectomy were compared with a control group (non-splenectomized patients) matched for sex, age, pretransfusional Hb, chelation therapy, and durati...

journal_title：European journal of haematology

authors： Casale M,Cinque P,Ricchi P,Costantini S,Spasiano A,Prossomariti L,Minelli S,Frega V,Filosa A

更新日期：2013-07-01 00:00:00

abstract：:Splenic volume was measured by visual assessment of planar images of the spleen, and also by single photon emission computerised tomography (SPECT) using 99mtechnetium tin colloid, in a group of 33 patients with primary thrombocythaemia (PT) or reactive thrombocytosis. Volumes greater than 337 cm3 correlated strongly ...

journal_title：European journal of haematology

authors： Messinezy M,Chapman R,Dudley JM,Nunan TO,Pearson TC

更新日期：1988-04-01 00:00:00

abstract：INTRODUCTION/OBJECTIVES:Acute myeloid leukemia (AML) accounts for 90% of all cases of acute leukemia in adults. In Brazil, the mortality from myeloid leukemia is 1.74/100 000 men and 1.37/100 000 women. Our aim was to review and update guidelines of the Brazilian Society of Bone Marrow Transplantation on indications of...

journal_title：European journal of haematology

authors： Silla L,Dulley F,Saboya R,Kerbauy F,de Moraes Arantes A,Pezzi A,Gross LG,Paton E,Hamerschlak N

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To determine the safety, dose-limiting toxicity and maximum tolerated dose (MTD) of the novel hydroxamate histone deacetylase inhibitor belinostat (PXD101) in patients with advanced hematological neoplasms. PATIENTS AND METHODS:Sequential dose-escalating cohorts of three to six patients with hematological mali...

journal_title：European journal of haematology

authors： Gimsing P,Hansen M,Knudsen LM,Knoblauch P,Christensen IJ,Ooi CE,Buhl-Jensen P

更新日期：2008-09-01 00:00:00

abstract：:Over the last two decades, the role of microRNAs has been extensively investigated, and it has become clear that these small non-coding RNAs play an essential role in several biological processes including erythropoiesis and that their dysregulation is associated with pathologies. Recent technical innovations have con...

journal_title：European journal of haematology

authors： Azzouzi I,Schmugge M,Speer O

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:A subset analysis of the randomised, phase 3, MDS-004 study to evaluate outcomes in patients with International Prognostic Scoring System (IPSS)-defined Low-/Intermediate (Int)-1-risk myelodysplastic syndromes (MDS) with isolated del(5q). METHODS:Patients received lenalidomide 10 mg/d (days 1-21; n = 47) or ...

journal_title：European journal of haematology

authors： Giagounidis A,Mufti GJ,Mittelman M,Sanz G,Platzbecker U,Muus P,Selleslag D,Beyne-Rauzy O,te Boekhorst P,del Cañizo C,Guerci-Bresler A,Nilsson L,Lübbert M,Quesnel B,Ganser A,Bowen D,Schlegelberger B,Göhring G,Fu T,Be

更新日期：2014-11-01 00:00:00

abstract：:Langerhans cells originate in bone marrow and probably belong to the monocyte-macrophage lineage. CD1 is a specific marker of Langerhans cells. By immunofluorescence and immunoelectron microscopy, CD1a antigen and myeloid markers (CD11, CD13, CD14, CD15, CD33, HLA-DR) were studied in 53 cases of acute myeloid leukemia...

journal_title：European journal of haematology

authors： Misery L,Campos L,Dezutter-Dambuyant C,Guyotat D,Treille D,Schmitt D,Thivolet J

更新日期：1992-01-01 00:00:00

abstract：:A patient presented with symptoms of cerebellar degeneration and nephrotic syndrome. A work-up at that time failed to reveal an underlying disease; however, 20 months later Hodgkin's disease was diagnosed. Hodgkin's lymphadenopathy developed 2 wk after prednisone therapy for the nephrotic syndrome had been discontinue...

journal_title：European journal of haematology

authors： Spyridonidis A,Fischer KG,Glocker FX,Fetscher S,Klisch J,Behringer D

更新日期：2002-05-01 00:00:00

abstract：:In further studying the mechanism of action of IFN-alpha in HCL, we cultured the HCL cell line JOK-1 and the IFN-sensitive Burkitt cell line Daudi with and without IFN-alpha and investigated the changes in density of a number of surface antigens by use of mAb and flow cytometry analyses. During culture with IFN-alpha,...

journal_title：European journal of haematology

authors： Nielsen B,Madsen PS,Jensen AW,Hokland P,Hokland M

更新日期：1992-03-01 00:00:00

abstract：:6 patients with massive splenomegaly but no peripheral adenopathy were diagnosed by splenectomy as having lymphoma; and were found to have widespread disease. Despite the seriousness of their illness at presentation, all have survived for a median time of 101.5 months and reached complete remission. ...

journal_title：European journal of haematology

authors： King DJ,Dawson AA,Thompson WD

更新日期：1987-02-01 00:00:00

abstract：INTRODUCTION:Outcome of patients with standard-risk (SR) multiple myeloma (MM) has improved; however, subsets of patients do worse than expected. We sought to identify the factors associated with inferior outcome. METHODS:We evaluated 51 patients with SR MM that received upfront autologous hematopoietic stem cell tran...

journal_title：European journal of haematology

authors： Badar T,Srour S,Bashir Q,Shah N,Al-Atrash G,Hosing C,Popat U,Nieto Y,Orlowski RZ,Champlin R,Qazilbash MH

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:Disseminated adenovirus (AdV) infections following allogeneic stem cell transplantation (allo-SCT) are increasingly recognised, particularly in children. This study evaluated the clinical relevance of disseminated AdV infections in adult allo-SCT recipients, after different conditioning regimens. METHODS:In...

journal_title：European journal of haematology

authors： Kalpoe JS,van der Heiden PL,Barge RM,Houtzager S,Lankester AC,van Tol MJ,Kroes AC

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVES:Northern Norway consists of a multiethnic population of Sámi and non-Sámi. We evaluated iron status in these two groups with respect to gender, age and residence. METHODS:In 2002-2004, a cross-sectional study of health and living conditions in areas with both Sámi and Norwegian populations, SAMINOR, was per...

journal_title：European journal of haematology

authors： Broderstad AR,Melhus M,Lund E

更新日期：2007-11-01 00:00:00

abstract：:Plasma and cellular pharmacokinetics of m-AMSA were investigated in 5 patients with acute leukemia, using HPLC. The pharmacokinetic data served as a guideline for in vitro toxicity tests on clonogenic bone marrow cells. m-AMSA was administered as a 3-hour intravenous infusion of 100 mg/m2. Median plasma and nucleated ...

journal_title：European journal of haematology

authors： Linssen P,Brons P,Knops G,Wessels H,de Witte T

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:Warfarin represents the most commonly prescribed oral anticoagulants, which functions as an antagonist of vitamin K, an essential factor of blood coagulation cascade. Warfarin has a narrow therapeutic index. An insufficient dose can cause failure of antithrombotic effect, and an overdose increases a risk of b...

journal_title：European journal of haematology

authors： Krajčíová L,Petrovič R,Déžiová L,Chandoga J,Turčáni P

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Since a study published in 2002 showed a survival advantage of melphalan-only conditioning for stem cell transplantation (HSCT) over melphalan-total body irradiation (mel-TBI) in patients with multiple myeloma (MM), most centers abandoned mel-TBI. Mel-TBI causes more early toxicity and is more...

journal_title：European journal of haematology

authors： Munker R,Baghian A,Koleva Y,Andrews P,Matharoo GS,Wright AE,Saba NS,Weiner RS,Safah H

更新日期：2017-07-01 00:00:00

abstract：:Ibrutinib has now been approved for treatment of chronic lymphocytic leukemia (CLL) in both front-line setting and as later-line treatment. However, knowledge about the outcomes and adverse events (AE) among patients at a population-based level is still limited. OBJECTIVES:To report outcomes and AEs in a population-b...

journal_title：European journal of haematology

authors： Aarup K,Rotbain EC,Enggaard L,Pedersen RS,Bergmann OJ,Thomsen RH,Frederiksen M,Frederiksen H,Nielsen T,Christiansen I,Andersen MA,Niemann CU

更新日期：2020-11-01 00:00:00