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Real-world outcomes for 205 patients with chronic lymphocytic leukemia treated with ibrutinib.

Abstract：

:Ibrutinib has now been approved for treatment of chronic lymphocytic leukemia (CLL) in both front-line setting and as later-line treatment. However, knowledge about the outcomes and adverse events (AE) among patients at a population-based level is still limited. OBJECTIVES:To report outcomes and AEs in a population-based cohort treated with ibrutinib outside clinical trials. METHODS:We conducted a multicenter, retrospective cohort study including all patients with CLL treated with ibrutinib. RESULTS:In total, 205 patients were included of whom 39 (19%) were treatment-naïve. The median follow-up was 21.4 months (interquartile range (IQR), 11.9,32.8), the estimated overall survival at 12 months was 88.8% (95% confidence interval (CI); 84.3%, 93.3%), and the estimated progression-free survival at 12 months was 86.3% (95% CI; 81.3%, 91.2%). During follow-up, 200 (97.6%) patients had at least one AE and 100 (48.8%) patients had at least one grade ≥3 AE. Eighty-six patients (42.0%) discontinued ibrutinib, hereof 47 (54.7%) due to AEs and 19 (22.1%) had progression of CLL or Richter transformation. CONCLUSIONS:In our study, we find comparable, though slightly inferior, overall, and progression-free survival, and discontinuation due to toxicity was higher compared with clinical trials. Patient training and information may improve treatment adherence outside clinical trials.

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Aarup K,Rotbain EC,Enggaard L,Pedersen RS,Bergmann OJ,Thomsen RH,Frederiksen M,Frederiksen H,Nielsen T,Christiansen I,Andersen MA,Niemann CU

doi

10.1111/ejh.13499

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

646-654

issue

5

eissn

0902-4441

issn

1600-0609

journal_volume

105

pub_type

杂志文章

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