On mouse and man: neutrophil gelatinase associated lipocalin is not involved in apoptosis or acute response.

abstract：OBJECTIVE:A subset analysis of the randomised, phase 3, MDS-004 study to evaluate outcomes in patients with International Prognostic Scoring System (IPSS)-defined Low-/Intermediate (Int)-1-risk myelodysplastic syndromes (MDS) with isolated del(5q). METHODS:Patients received lenalidomide 10 mg/d (days 1-21; n = 47) or ...

journal_title：European journal of haematology

authors： Giagounidis A,Mufti GJ,Mittelman M,Sanz G,Platzbecker U,Muus P,Selleslag D,Beyne-Rauzy O,te Boekhorst P,del Cañizo C,Guerci-Bresler A,Nilsson L,Lübbert M,Quesnel B,Ganser A,Bowen D,Schlegelberger B,Göhring G,Fu T,Be

更新日期：2014-11-01 00:00:00

abstract：:Propagation of the vaso-occlusive process in sickle cell anaemia (SCA) is a complex process involving the adhesion of steady-state SCA patients red cells and reticulocytes to the vascular endothelium. The effect of hydroxyurea therapy (HUT) on the adhesive properties of sickle cells and the expression of adhesion mole...

journal_title：European journal of haematology

authors： Gambero S,Canalli AA,Traina F,Albuquerque DM,Saad ST,Costa FF,Conran N

更新日期：2007-02-01 00:00:00

abstract：:An unusual case having IgM monoclonal gammopathy with clinical and pathologic features of multiple myeloma (MM) in association with neutrophilia and nephrotic syndrome is reported. The patient showed lytic bone lesions, decreased IgG and IgA levels, Bence-Jones proteinuria, nephrotic proteinuria with edema, and histol...

journal_title：European journal of haematology

authors： Gnerre P,Ottonello L,Montecucco F,Boero M,Dallegri F

更新日期：2007-07-01 00:00:00

abstract：:In March 1981, a 53-year-old man presented with itching and was diagnosed as having myelofibrosis. There was gradual enlargement of the spleen over the following 5 yr. His spleen had to be removed in February 1986 because of physical discomfort. 3 months post-splenectomy he became polycythaemic. Bone marrow examinatio...

journal_title：European journal of haematology

authors： Dokal I,Pagliuca A,Deenmamode M,Mufti GJ,Lewis SM

更新日期：1989-01-01 00:00:00

abstract：AIMS:Platelets retain cytoplasmic messenger RNA and are capable of protein biosynthesis. Several diseases are known to impact the platelet transcriptome but the effect of non-valvular atrial fibrillation (NVAF) on platelet RNA transcript is essentially unknown. The aim of this study was to evaluate the impact of NVAF o...

journal_title：European journal of haematology

authors： Wysokinski WE,Tafur A,Ammash N,Asirvatham SJ,Wu Y,Gosk-Bierska I,Grill DE,Slusser JP,Mruk J,McBane RD

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Diamond-Blackfan anemia (DBA) is characterized by hypoplastic anemia, congenital anomalies, and a predisposition for malignancies. Most of our understanding of this disorder stems from molecular studies combined with extensive data input from international patient registries. OBJECTIVES:To create an overv...

journal_title：European journal of haematology

authors： van Dooijeweert B,van Ommen CH,Smiers FJ,Tamminga RYJ,Te Loo MW,Donker AE,Peters M,Granzen B,Gille HJJP,Bierings MB,MacInnes AW,Bartels M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The single nucleotide polymorphism SNP309 with a change from T to G in the promoter region of the MDM2 gene is shown to increase the MDM2 protein levels and attenuate the p53 levels and associates with disease progression in several tumors. OBJECTIVE:In this study, the role of the polymorphism was investiga...

journal_title：European journal of haematology

authors： Willander K,Ungerbäck J,Karlsson K,Fredrikson M,Söderkvist P,Linderholm M

更新日期：2010-09-01 00:00:00

abstract：:Tumor necrosis factor (TNF)/cachectin can produce both beneficial and harmful manifestations. Mechanisms may operate to counteract potentially harmful effects such as shock and cachexia. The TNF binding protein (TNF-BP), which is found at increased levels in serum and urine of patients with chronic renal failure, may ...

journal_title：European journal of haematology

authors： Olsson I,Lantz M,Nilsson E,Peetre C,Thysell H,Grubb A,Adolf G

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVE:A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. RESULTS:The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-k...

journal_title：European journal of haematology

authors： Vyhlídalová I,Uherková L,Pleschnerová M,Špička I,Březinová J,Michalová K,Čermáková K,Polanská V,Jedelský PL,Hamšíková E,Kuželová K,Stöckbauer P

更新日期：2015-10-01 00:00:00

abstract：:Copper deficiency is an established cause of hematological abnormalities but is frequently misdiagnosed. Copper deficiency can present as a combination of hematological and neurological abnormalities and it may masquerade as a myelodysplastic syndrome. We reviewed the records of patients with hypocupremia and hematolo...

journal_title：European journal of haematology

authors： Halfdanarson TR,Kumar N,Li CY,Phyliky RL,Hogan WJ

更新日期：2008-06-01 00:00:00

abstract：:Although targeted therapies are used increasingly in hematologic malignancies, we are unaware of any prior studies of radioimmunotherapy (RAIT) in B-acute lymphoblastic leukemia (ALL), even though this radiosensitive tumor expresses CD22, potentially a good target for this approach. Here, we report a patient with Phil...

journal_title：European journal of haematology

authors： Chevallier P,Bodet-Milin C,Robillard N,Eugene T,Menard A,Le Houerou C,Guillaume T,Delaunay J,Escoffre-Barbe M,Wegener WA,Goldenberg DM,Kraeber-Bodéré F

更新日期：2013-12-01 00:00:00

abstract：:GM-CSF may induce pulmonary complications, such as dyspnea with temporary decreases in oxygen saturation described as first dose effect for higher dosages of intravenous rhGM-CSF. This study investigated possible pulmonary disturbances in adult de novo AML patients receiving yeast rhGM-CSF 24 h prior to chemotherapy u...

journal_title：European journal of haematology

authors： Zühlsdorf M,von Eiff M,Thomas M,Büchner T

更新日期：1997-11-01 00:00:00

abstract：:Administration of both glycosylated and non-glycosylated recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) induces an immediate transient granulocytopenia of 1-3 hours' duration. In order to explore this phenomenon, granulocytes were labelled with 111Indium and the effect on the kinetics of...

journal_title：European journal of haematology

authors： Hovgaard D,Schifter S,Rabøl A,Mortensen BT,Nissen NI

更新日期：1992-04-01 00:00:00

abstract：:The aim of this study was to test the association between hematological/genetic factors and cerebral vasculopathy in children with sickle cell anemia (SCA). A group with cerebral vasculopathy (VASC) was composed of children who had stroke (n = 6), silent infarct (n = 11), or an abnormal transcranial Doppler (n = 5). E...

journal_title：European journal of haematology

authors： Joly P,Garnier N,Kebaili K,Renoux C,Dony A,Cheikh N,Renard C,Ceraulo A,Cuzzubbo D,Pondarré C,Martin C,Pialoux V,Francina A,Bertrand Y,Connes P

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The impact of coronavirus disease 2019 (COVID-19) in haematological patients (HP) has not been comprehensively reported. METHODS:We analysed 39 patients with SARS-CoV-2 infection and haematological malignancies. Clinical characteristics and outcomes were compared to a matched control group of 53 non-cancer ...

journal_title：European journal of haematology

authors： Sanchez-Pina JM,Rodríguez Rodriguez M,Castro Quismondo N,Gil Manso R,Colmenares R,Gil Alos D,Paciello ML,Zafra D,Garcia-Sanchez C,Villegas C,Cuellar C,Carreño-Tarragona G,Zamanillo I,Poza M,Iñiguez R,Gutierrez X,Alonso R

更新日期：2020-11-01 00:00:00

abstract：:MALT lymphoma is usually described in association with Helicobacter pylori, HCV, HHV8, Campylobacter jejuni or in a setting of overreactive immunity. In HIV(+) patients, MALT lymphoma is most commonly described in children. We describe here an original case of HIV(+) MALT lymphoma with bronchial, conjuctival and laryn...

journal_title：European journal of haematology

authors： Girard T,Luquet-Besson I,Baran-Marszak F,Raphaël M,Boué F

更新日期：2005-01-01 00:00:00

abstract：:Tissue factor (TF) production is under strict control in mature monocytic cells. However, constitutive expression of TF can be found in myelomonocytic cells and in haematopoietic cells arrested at an early stage of differentiation. In this paper we show that TF expression is down-regulated during the monocyte/granuloc...

journal_title：European journal of haematology

authors： Tenno T,Oberg F,Nilsson K,Siegbahn A

更新日期：1999-08-01 00:00:00

abstract：:Hemoglobinopathies are the most common autosomal recessive disorders and are mostly inherited in a recessive manner. However, certain mutations can affect the globin chain stability, leading to dominant forms of thalassemia. The aim of this work was the molecular and structural characterization of two heterozygous in-...

journal_title：European journal of haematology

authors： Scheps KG,Hasenahuer MA,Parisi G,Targovnik HM,García E,Veber ES,Crisp R,Elena G,Varela V,Fornasari MS

更新日期：2018-06-01 00:00:00

abstract：:Implantation of Yoshida ascites sarcoma in rats was found to lead to a reduction in the hemoglobin content, the erythrocyte count and the packed cell volume of blood to 30% of normal in 4 d; however, there was no decrease in the mean cell hemoglobin, the mean cell volume and the mean corpuscular hemoglobin concentrati...

journal_title：European journal of haematology

authors： Bhanushali AA,Raghunathan R,Kalraiya RD,Mehta NG

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION/OBJECTIVES:Acute myeloid leukemia (AML) accounts for 90% of all cases of acute leukemia in adults. In Brazil, the mortality from myeloid leukemia is 1.74/100 000 men and 1.37/100 000 women. Our aim was to review and update guidelines of the Brazilian Society of Bone Marrow Transplantation on indications of...

journal_title：European journal of haematology

authors： Silla L,Dulley F,Saboya R,Kerbauy F,de Moraes Arantes A,Pezzi A,Gross LG,Paton E,Hamerschlak N

更新日期：2017-02-01 00:00:00

abstract：:We reviewed the indications for and the results of bone marrow examination (BME) from HIV-infected patients as an attempt to improve its diagnostic yield. One-hundred-and-eight bone marrow specimens from 90 patients during a 3-year period were examined. A cytological, histological and microbiological study was carried...

journal_title：European journal of haematology

authors： Ciaudo M,Doco-Lecompte T,Guettier C,d'Agay MF,David F,Rioual N,Buu-Hoi A,Molina JM,Kazatchkine M,Modai J

更新日期：1994-09-01 00:00:00

abstract：:The Hermansky-Pudlak syndrome (HPS) is a rare genetically heterogeneous autosomal recessive disorder, characterized by tyrosinase-positive oculocutaneous albinism, platelet dysfunction and lysosomal ceroid lipofuscin storage. This is caused by defects in lysosome-related organelles. In humans eight different types of ...

journal_title：European journal of haematology

authors： Korswagen LA,Huizing M,Simsek S,Janssen JJ,Zweegman S

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study is to assess the quality of life (QoL) of Chinese adults with idiopathic thrombocytopenic purpura (ITP). METHODS:The Chinese (mainland) version of Medical Outcome Study SF-36 form (SF-36) Health Survey was used to measure health-related QoL of 236 adults with ITP in a cross-sectional s...

journal_title：European journal of haematology

authors： Zhou Z,Yang L,Chen Z,Chen X,Guo Y,Wang X,Dong X,Wang T,Zhang L,Qiu Z,Yang R

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Since a study published in 2002 showed a survival advantage of melphalan-only conditioning for stem cell transplantation (HSCT) over melphalan-total body irradiation (mel-TBI) in patients with multiple myeloma (MM), most centers abandoned mel-TBI. Mel-TBI causes more early toxicity and is more...

journal_title：European journal of haematology

authors： Munker R,Baghian A,Koleva Y,Andrews P,Matharoo GS,Wright AE,Saba NS,Weiner RS,Safah H

更新日期：2017-07-01 00:00:00

abstract：:Cardiac disease is the primary cause of mortality in beta-thalassemia patients. Except for ventricular dysfunction and pulmonary hypertension that represent the main forms of heart disease in these patients, valvular abnormalities including valvular regurgitation, endocardial thickening and calcification and mitral va...

journal_title：European journal of haematology

authors： Farmakis D,Deftereos S,Giakoumis A,Polymeropoulos E,Aessopos A

更新日期：2004-04-01 00:00:00

abstract：:Thirty-four patients with myelodysplastic syndromes, 23 men and 11 women, aged between 47 and 80 years, with all types of myelodysplastic syndromes were treated with 13-cis-retinoic acid. The dose of retinoic acid ranged between 10 and 60 mg/m2/daily and was administered in combination with vitamin E to diminish side ...

journal_title：European journal of haematology

authors： Bourantas KL,Tsiara S,Christou L

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:To correlate the clinical and hematological features of β-globin gene haplotypes with the oxidative stress status in pediatric patients with sickle cell disease (SCD). METHODS:A total of 95 patients with SCD and 40 healthy children were studied. The β-globin cluster, plasma lipid peroxidation (LPO) and plasm...

journal_title：European journal of haematology

authors： Rusanova I,Escames G,Cossio G,de Borace RG,Moreno B,Chahboune M,López LC,Díez T,Acuña-Castroviejo D

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:To characterize the underlying genetic and molecular defects in a consanguineous family with lifelong blood disorder manifested with thrombocytopenia (low platelets count) and anemia. METHODS:Genetic linkage analysis, exome sequencing, and functional genomics were carried out to identify and characterize the...

journal_title：European journal of haematology

authors： Melhem M,Abu-Farha M,Antony D,Madhoun AA,Bacchelli C,Alkayal F,AlKhairi I,John S,Alomari M,Beales PL,Alsmadi O

更新日期：2017-03-01 00:00:00

abstract：:It is well-documented that iron chelation by desferrioxamine protects/improves the cardiac function in blood transfusion-dependent children suffering from beta-thalassaemia. In patients who do not become dependent upon blood transfusion until adulthood (ANT-patients), iron chelation by desferrioxamine may affect the c...

journal_title：European journal of haematology

authors： Jensen PD,Olsen N,Bagger JP,Jensen FT,Christensen T,Ellegaard J

更新日期：1997-10-01 00:00:00

abstract：:Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the co...

journal_title：European journal of haematology

authors： Tsutsumi Y,Tanaka J,Kanamori H,Musashi M,Minami H,Fukushima A,Yamato H,Ehira N,Kawamura T,Obara S,Ogura N,Asaka M,Imamura M,Masauzi N

更新日期：2004-12-01 00:00:00