Abstract:
BACKGROUND:The impact of coronavirus disease 2019 (COVID-19) in haematological patients (HP) has not been comprehensively reported. METHODS:We analysed 39 patients with SARS-CoV-2 infection and haematological malignancies. Clinical characteristics and outcomes were compared to a matched control group of 53 non-cancer patients with COVID-19. Univariate and multivariate analyses were carried out to assess the risk factors associated with poor outcome. RESULTS:The most frequent haematological diseases were lymphoma (30%) and multiple myeloma (30%). Eighty-seven % HP developed moderate or severe disease. Patients with haematological malignancies had a significantly higher mortality rate compared to non-cancer patients (35.9% vs 13.2%; P = .003 (odds ratio 6.652). The worst outcome was observed in chronic lymphocytic leukaemia patients. Only age >70 years and C reactive protein >10 mg/dl at admission were associated with higher risk of death (odds ratio 34.86, P = .003 and 13.56,P = .03). Persistent viral sheddind was detected in 5 HP. Active chemotherapy, viral load at diagnosis and COVID-19 therapy were not predictors of outcome. CONCLUSION:Mortality of COVID-19 is significantly higher in patients with haematological malignancies compared to non-cancer patients. The impact of persistent viral shedding must be considered in order to re-start therapies and maintain infectious control measures.
journal_name
Eur J Haematoljournal_title
European journal of haematologyauthors
Sanchez-Pina JM,Rodríguez Rodriguez M,Castro Quismondo N,Gil Manso R,Colmenares R,Gil Alos D,Paciello ML,Zafra D,Garcia-Sanchez C,Villegas C,Cuellar C,Carreño-Tarragona G,Zamanillo I,Poza M,Iñiguez R,Gutierrez X,Alonso Rdoi
10.1111/ejh.13493subject
Has Abstractpub_date
2020-11-01 00:00:00pages
597-607issue
5eissn
0902-4441issn
1600-0609journal_volume
105pub_type
杂志文章abstract::Cancer cells are characterized by having chromosomal abnormalities. The number of aberrations and the specific chromosomes affected are likely correlated with tumor progression. In this study, we analyzed the karyotype of 126 plasma cell leukemia (PCL) patients to identify the most frequently occurring imbalances and ...
journal_title:European journal of haematology
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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pub_type: 杂志文章,多中心研究
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journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
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journal_title:European journal of haematology
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doi:10.1111/j.1600-0609.1988.tb01185.x
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journal_title:European journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1600-0609.1992.tb01793.x
更新日期:1992-01-01 00:00:00
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journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
pub_type: 临床试验,杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
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pub_type: 杂志文章
doi:10.1034/j.1600-0609.2000.065005306.x
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journal_title:European journal of haematology
pub_type: 杂志文章,多中心研究
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journal_title:European journal of haematology
pub_type: 杂志文章,评审
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journal_title:European journal of haematology
pub_type: 杂志文章
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更新日期:1987-09-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
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更新日期:1988-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:European journal of haematology
pub_type: 杂志文章,评审
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更新日期:2003-04-01 00:00:00