Abstract:
:Copper deficiency is an established cause of hematological abnormalities but is frequently misdiagnosed. Copper deficiency can present as a combination of hematological and neurological abnormalities and it may masquerade as a myelodysplastic syndrome. We reviewed the records of patients with hypocupremia and hematologic abnormalities identified between 1970 and 2005. Patients with hypocupremia unrelated to copper deficiency (e.g. Wilson's disease) were excluded. Forty patients with copper deficiency and hematological abnormalities were identified. Ten patients (25%) had undergone bariatric (weight reduction) surgery and an additional 14 patients (35%) had undergone surgery on the gastrointestinal tract, most commonly gastric resection. In 12 cases, no cause for copper deficiency was identified. Anemia and neutropenia were the most common hematologic abnormalities identified and the majority of the patients also had neurologic findings, most commonly due to myeloneuropathy. Abnormalities observed on bone marrow examination including vacuoles in myeloid precursors, iron-containing plasma cells, a decrease in granulocyte precursors and ring sideroblasts may be valuable clues to the diagnosis. Copper deficiency is an uncommon but very treatable cause of hematologic abnormalities.
journal_name
Eur J Haematoljournal_title
European journal of haematologyauthors
Halfdanarson TR,Kumar N,Li CY,Phyliky RL,Hogan WJdoi
10.1111/j.1600-0609.2008.01050.xsubject
Has Abstractpub_date
2008-06-01 00:00:00pages
523-31issue
6eissn
0902-4441issn
1600-0609pii
EJH1050journal_volume
80pub_type
杂志文章,评审abstract::Tumor necrosis factor (TNF)/cachectin can produce both beneficial and harmful manifestations. Mechanisms may operate to counteract potentially harmful effects such as shock and cachexia. The TNF binding protein (TNF-BP), which is found at increased levels in serum and urine of patients with chronic renal failure, may ...
journal_title:European journal of haematology
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journal_title:European journal of haematology
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journal_title:European journal of haematology
pub_type: 杂志文章
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journal_title:European journal of haematology
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