当前位置： SCI文献检索 > EUROPEAN JOURNAL OF HAEMATOLOGY期刊下所有文献 > Infections after CD34-selected or unmanipulated autologous hematopoietic stem cell transplantation.

Infections after CD34-selected or unmanipulated autologous hematopoietic stem cell transplantation.

Abstract：

:Immune reconstitution may be delayed after CD34-selected compared with unmanipulated autologous peripheral blood stem cell transplantation (PBSCT), resulting in a theoretically increased risk of infections. In a case-control matched study we compared the incidence of infection in 25 recipients of CD34-selected PBSC (CD34 group) and 75 recipients of unmanipulated PBSC (PBSC group) transplants. The population included 52 males and 48 females suffering from non-Hodgkin's lymphoma (n = 32), Hodgkin's disease (n = 8), multiple myeloma (n = 40) or breast cancer (n = 20). Neutrophil engraftment was comparable in the two groups. The actuarial incidence of infection was similar in the two groups (56% vs. 49% at day 30, and 70% vs. 64% at 1 yr respectively). The proportion of patients with 1, 2 or 3 infections, the number of infectious event per patient (1.32 vs. 1.04; NS), the number of infections before day 15 or 30, between days 31 and 100 or after day 100, the risk of varicella-zoster virus or cytomegalovirus infection or disease, or the use of antibiotic or antifungal therapy, were not increased in the CD34 compared with the PBSC group. The main agents responsible for infection were bacteria, particularly gram-positive cocci, in both groups. Bacteremia accounted for 33% of all infectious events in the CD34 group vs. 16% in the PBSC group (P < 0.05). Fungal infections were rare. In conclusion, our results do not support the notion that CD34-selection of the graft is associated with an increased rate of infection after autologous PBSC transplantation. The role of extended infection prophylaxis should be evaluated.

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Frère P,Pereira M,Fillet G,Beguin Y

doi

10.1111/j.1600-0609.2005.00569.x

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

102-8

issue

2

eissn

0902-4441

issn

1600-0609

pii

EJH569

journal_volume

76

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF HAEMATOLOGY文献大全
  • Hodgkin's disease and age.

    abstract：:506 unselected, previously untreated patients with Hodgkin's disease were treated at the Finsen Institute between 1969 and 1983. The prognostic significance of age, sex, stage, systemic symptoms, histologic subtype, number of involved nodal regions, total tumour burden (peripheral + intrathoracic nodal tumour burden, ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：

    authors： Specht L,Nissen NI

    更新日期：1989-08-01 00:00:00

  • Prognostic significance of apoptotic index in multiple myeloma patients treated by conventional therapy and novel agents, thalidomide and bortezomib.

    abstract：OBJECTIVE:To assess the outcome of the measurement of apoptotic index in myeloma patients treated by conventional chemotherapy and novel drugs with biological mechanism of action, thalidomide and bortezomib. PATIENTS AND METHODS:In a cohort of 189 patients with newly diagnosed multiple myeloma from November 1997 throu...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2009.01321.x

    authors： Minarik J,Scudla V,Ordeltova M,Bacovsky J,Pika T,Langova K

    更新日期：2009-12-01 00:00:00

  • T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice.

    abstract：OBJECTIVES:Iron-overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. However, the precise mechanisms of iron entry and sequestration in the heart are still unclear. Our previous study showed that Fe(2+) uptake in thalassemic cardiomyocytes are mainly mediated by T-type calci...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2012.01779.x

    authors： Kumfu S,Chattipakorn S,Chinda K,Fucharoen S,Chattipakorn N

    更新日期：2012-06-01 00:00:00

  • FDA's and EMA's approval of brentuximab vedotin for advanced Hodgkin lymphoma: Another player in the town?

    abstract：:ECHELON-1 study is a randomized open-labeled controlled trial investigating whether addition of brentuximab vedotin to chemotherapy offers benefit over the standard chemotherapy regimen in advanced Hodgkin lymphoma. After a median follow-up of 24.6 months, it has met its primary endpoint the reduction of modified prog...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/ejh.13269

    authors： Milunović V,Mišura Jakobac K,Kursar M,Mandac Rogulj I,Ostojić Kolonić S

    更新日期：2019-09-01 00:00:00

  • Neurological symptoms in essential thrombocythemia: impact of JAK2V617F mutation and response to therapy.

    abstract：:Patients with essential thrombocythemia (ET) often suffer from neurological symptoms (NS) not ever resulting from previous thrombotic cerebral events (TCE). We reported NS occurred in 282 patients, in order to identify the factors influencing ET-related NS in the absence of TCE, and the response to therapy. Overall, 1...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12638

    authors： Aroldi A,Cecchetti C,Colombo A,Cattaneo L,Pioltelli PE,Pogliani EM,Elli EM

    更新日期：2016-06-01 00:00:00

  • Serum levels of IL-6 and its soluble receptor (sIL-6R) in Waldenström's macroglobulinemia.

    abstract：BACKGROUND:Interleukin-6 (IL-6) is a multifunctional cytokine that plays roles in the immune response, inflammation and hematopoiesis. Serum IL-6 levels have reported to reflect disease severity and high tumor burden in multiple myeloma (MM) patients and to correlate with several other laboratory parameters. Serum-solu...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0609.2001.00152.x

    authors： Hatzimichael EC,Christou L,Bai M,Kolios G,Kefala L,Bourantas KL

    更新日期：2001-01-01 00:00:00

  • Renal aspects of thalassaemia a changing paradigm.

    abstract：:Beta-thalassaemia is characterised by progressive anaemia necessitating regular blood transfusions to sustain life. With the advent of effective chelating agents that can reduce the iron burden and extend patients' survival, renal disease, as in other ageing populations, has become more prevalent. In recent years, chr...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.2012.01819.x

    authors： Bhandari S,Galanello R

    更新日期：2012-09-01 00:00:00

  • Improved survival from fungaemia in patients with haematological malignancies: analysis of risk factors for death and usefulness of early antifungal therapy.

    abstract：:Fourty-three episodes of fungaemia encountered from 1978 to 1991 in 43 patients with haematological malignancies are reviewed here to analyse the risk factors for death and to evaluate the efficacy of early antifungal therapy. Low serum cholinesterase and elevated serum blood urea nitrogen were significantly associate...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1993.tb00617.x

    authors： Iwama A,Yoshida M,Miwa A,Obayashi T,Sakamoto S,Miura Y

    更新日期：1993-09-01 00:00:00

  • Changes in serum erythropoietin and the reticulocyte count during chemotherapy for leukemias.

    abstract：:We serially determined serum erythropoietin (Epo) and the reticulocyte count in patients with various types of leukemia during chemotherapy. Serum Epo increased soon after the initiation of chemotherapy and decreased after the termination of therapy irrespective of the types of leukemia or treatment regimen. However, ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1996.tb01397.x

    authors： Sawabe Y,Kikuno K,Iseki T,Lida S,Tabata Y,Yonemitsu H

    更新日期：1996-11-01 00:00:00

  • Cytoskeletal regulation of chemotactic receptors: molecular complexation of N-formyl peptide receptors with G proteins and actin.

    abstract：:Signal transduction via receptors for N-formylmethionyl peptide chemoattractants (FPR) on human neutrophils is a highly regulated process. It involves direct interaction of receptors with heterotrimeric G-proteins and may be under the control of cytoskeletal elements. Evidence exists suggesting that the cytoskeleton a...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.1993.tb01610.x

    authors： Jesaitis AJ,Klotz KN

    更新日期：1993-11-01 00:00:00

  • A novel gene STORP (STOmatin-Related Protein) is localized 2 kb upstream of the promyelocytic gene on chromosome 15q22.

    abstract：:We generated a 100-kb map of the region 5' of the PML (promyelocytic leukemia) gene on human chromosome 15q22 and identified a new gene provisionally named STORP for stomatin-related protein. The STORP gene is positioned 2 kb upstream of the PML gene in a head-to-head configuration, and contains 7 exons spanning a gen...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0609.2000.90054.x

    authors： Gilles F,Glenn M,Goy A,Remache Y,Zelenetz AD

    更新日期：2000-02-01 00:00:00

  • Deferiprone-associated myelotoxicity.

    abstract：:Agranulocytosis developed in a 63-year-old patient with myelodysplasia 6 weeks after commencing treatment with the oral iron chelator deferiprone (L1, 1,2-dimethyl-3-hydroxypyrid-4-one, CP20) at a daily dose of 79 mg/kg. This was the 3rd case of agranulocytosis (neutrophils 0 x 10(9)/l) in clinical trials of L1 at the...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1600-0609.1994.tb01323.x

    authors： al-Refaie FN,Wonke B,Hoffbrand AV

    更新日期：1994-11-01 00:00:00

  • Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells.

    abstract：OBJECTIVES:Homoharringtonine (HHT) was efficient in therapying patients with acute myeloid leukemia (AML) in China, but little is known about the mechanism of its action. As the abnormal activation of JAK2 associated pathway is important to AML, we try to explore the effect of HHT on JAK2-STAT pathway in AML cells, thu...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2008.01116.x

    authors： Tong H,Ren Y,Zhang F,Jin J

    更新日期：2008-10-01 00:00:00

  • c-Met signaling promotes IL-6-induced myeloma cell proliferation.

    abstract：OBJECTIVES:Hepatocyte growth factor (HGF) is a constituent of the myeloma microenvironment and is elevated in sera from myeloma patients compared to healthy individuals. Increased levels of serum HGF predict a poor prognosis. It has previously been shown by us and others HGF can act as a growth factor to myeloma cells ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2009.01212.x

    authors： Hov H,Tian E,Holien T,Holt RU,Våtsveen TK,Fagerli UM,Waage A,Børset M,Sundan A

    更新日期：2009-04-01 00:00:00

  • Hematological manifestations of copper deficiency: a retrospective review.

    abstract：:Copper deficiency is an established cause of hematological abnormalities but is frequently misdiagnosed. Copper deficiency can present as a combination of hematological and neurological abnormalities and it may masquerade as a myelodysplastic syndrome. We reviewed the records of patients with hypocupremia and hematolo...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.2008.01050.x

    authors： Halfdanarson TR,Kumar N,Li CY,Phyliky RL,Hogan WJ

    更新日期：2008-06-01 00:00:00

  • Regulatory T-cell phenotype in association with large cell transformation of mycosis fungoides.

    abstract：INTRODUCTION:Tumor cells of primary cutaneous T-cell lymphomas are able to adopt a regulatory T-cell phenotype in vitro. The significance of this finding in vivo is matter of debate. METHODS:We stained five cases with transformed mycosis fungoides (MF) with an antibody against FOXP3, which is a sensitive and specific ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2006.00809.x

    authors： Hallermann C,Niermann C,Schulze HJ

    更新日期：2007-03-01 00:00:00

  • Intensive remission induction therapy for chronic myeloid leukemia in blast phase with a goal of post-remission bone marrow transplant--a pilot study.

    abstract：:An intensive protocol utilizing mitoxantrone, high-dose cytarabine, vincristine, etoposide and methylprednisolone as induction therapy for chronic myeloid leukemia in blast transformation is described. Fourteen patients were treated, with a remission/second chronic phase achieved in 64%. None of the 3 patients older t...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1996.tb00488.x

    authors： Lipton JH,Messner HA,Curtis JE,Atkins HL,Minden MD

    更新日期：1996-07-01 00:00:00

  • Efficient assay for evaluating human thrombopoiesis using NOD/SCID mice transplanted with cord blood CD34+ cells.

    abstract：:A suitable model for the preclinical study of human platelet production in vivo has not been available. NOD/SCID mice were characterized as representing an efficient engraftment model for human hematopoietic stem cells, which resulted in the production of human platelets. Here, we evaluated in vivo human thrombopoiesi...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2006.00783.x

    authors： Suzuki K,Hiramatsu H,Fukushima-Shintani M,Heike T,Nakahata T

    更新日期：2007-02-01 00:00:00

  • Severe IgA-mediated auto-immune haemolytic anaemia in a 48-yr-old woman.

    abstract：:Auto-immune haemolytic anaemia (AIHA) is characterised by haemolysis associated with the presence of the immunoglobulins IgG, IgM or IgA, and/or components of the complement system on the red cell membrane. The immunoglobulins react as auto-antibodies against the red cell antigens of the patient. IgG antibodies and th...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0609.2003.02846.x

    authors： Bardill B,Mengis C,Tschopp M,Wuillemin WA

    更新日期：2003-01-01 00:00:00

  • Leucopoiesis versus concentration of cytokines in diffusion chamber cultures of mouse bone marrow cells: clues to the physiological roles of growth factors.

    abstract：:Physiological mechanisms that regulate formation of neutrophil granulocytes, macrophages and their precursor cells were studied with the diffusion chamber (DC) technique. DC inoculated with mouse bone marrow cells were implanted intraperitoneally into host mice. When these in vivo cultures had been established and the...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1989.tb00245.x

    authors： Benestad HB,Løvhaug D,Strøm-Gundersen I

    更新日期：1989-01-01 00:00:00

  • Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.

    abstract：OBJECTIVE:To correlate the clinical and hematological features of β-globin gene haplotypes with the oxidative stress status in pediatric patients with sickle cell disease (SCD). METHODS:A total of 95 patients with SCD and 40 healthy children were studied. The β-globin cluster, plasma lipid peroxidation (LPO) and plasm...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2010.01528.x

    authors： Rusanova I,Escames G,Cossio G,de Borace RG,Moreno B,Chahboune M,López LC,Díez T,Acuña-Castroviejo D

    更新日期：2010-12-01 00:00:00

  • Impact of central nervous system involvement in AML on outcomes after allotransplant and utility of pretransplant cerebrospinal fluid assessment.

    abstract：OBJECTIVE:The primary objective was to assess the effect of central nervous system involvement in acute myeloid leukemia (CNS-AML) on outcomes after allogeneic hematopoietic stem cell transplant (allo-HCT). The secondary objective was to assess the utility of pretransplant cerebrospinal fluid (CSF) assessment in AML. ...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/ejh.13314

    authors： Prem S,Atenafu EG,Avena J,Bautista R,Law A,Lam W,Michelis FV,Kim DDH,Viswabandya A,Lipton JH,Mattsson J,Kumar R

    更新日期：2019-11-01 00:00:00

  • Differences in the distribution of cytogenetic subtypes between multiple myeloma patients with and without a family history of monoclonal gammopathy and multiple myeloma.

    abstract：:We previously reported an increased risk of monoclonal gammopathy of undetermined significance (MGUS) in first-degree relatives of MGUS and multiple myeloma patients. Here, we examine whether primary cytogenetic categories of myeloma differ between patients with and without a family history of MGUS or myeloma. We stud...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12133

    authors： Greenberg AJ,Cousin M,Kumar S,Ketterling RP,Knudson RA,Larson D,Colby C,Scott C,Vachon CM,Rajkumar SV

    更新日期：2013-09-01 00:00:00

  • Impact of atrial fibrillation on platelet gene expression.

    abstract：AIMS:Platelets retain cytoplasmic messenger RNA and are capable of protein biosynthesis. Several diseases are known to impact the platelet transcriptome but the effect of non-valvular atrial fibrillation (NVAF) on platelet RNA transcript is essentially unknown. The aim of this study was to evaluate the impact of NVAF o...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12879

    authors： Wysokinski WE,Tafur A,Ammash N,Asirvatham SJ,Wu Y,Gosk-Bierska I,Grill DE,Slusser JP,Mruk J,McBane RD

    更新日期：2017-06-01 00:00:00

  • Protein Z levels and central retinal vein or artery occlusion.

    abstract：OBJECTIVES:Central retinal vein occlusion (CRVO) and central retinal artery occlusion (CRAO) are common disorders associated with risk factors for atherosclerosis. Protein Z is a cofactor for the inactivation of activated factor X (Xa) by the protein Z dependent protease inhibitor. Protein Z deficiency was recently lin...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2005.00529.x

    authors： Koren-Michowitz M,Eting E,Rahimi-Levene N,Garach-Jehoshua O,Volcheck Y,Kornberg A

    更新日期：2005-11-01 00:00:00

  • Acute tumour lysis syndrome following a single-dose corticosteroid in children with acute lymphoblastic leukaemia.

    abstract：:Acute tumour lysis syndrome (ATLS) is a well recognised complication of treatment of a variety of malignant disorders. It commonly occurs in patients with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL) with the administration of combined cytotoxic chemotherapy. It is rarely reported after single-...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1034/j.1600-0609.2001.066006404.x

    authors： Duzova A,Cetin M,Gümrük F,Yetgin S

    更新日期：2001-06-01 00:00:00

  • Flow cytometry immunophenotypic findings in chronic myelomonocytic leukemia and its utility in monitoring treatment response.

    abstract：:Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm, characterized by persistent monocytosis. Due to the lack of unique surface markers expressed by neoplastic monocytes and the frequent CD34-negative blast immunophenotype, the diagnostic value of flow cytometric immunophenotyping (...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12477

    authors： Shen Q,Ouyang J,Tang G,Jabbour EJ,Garcia-Manero G,Routbort M,Konoplev S,Bueso-Ramos C,Medeiros LJ,Jorgensen JL,Wang SA

    更新日期：2015-08-01 00:00:00

  • Factors influencing release of granulocyte-macrophage colony-stimulating activity from human mononuclear phagocytes.

    abstract：:Mononuclear phagocytes play an important role in the regulation of hematopoiesis, not only by producing regulatory monokines such as prostaglandins, tumor necrosis factor and interleukin-1 (IL-1), but also by the production of colony-stimulating activity (CSA). Previously, we have demonstrated that granulocyte-macroph...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1988.tb00209.x

    authors： Fibbe WE,Kluck PM,Duinkerken N,Voogt PJ,Willemze R,Falkenburg JH

    更新日期：1988-10-01 00:00:00

  • Prognostic value of serum M-protein doubling time at escape from plateau of multiple myeloma. The Finnish Leukaemia Group.

    abstract：:A long plateau phase is one of the strongest signs predicting long survival in multiple myeloma. The kinetics of escape from the plateau is, however, poorly known, and so is its influence on subsequent survival. During a 9-yr follow-up of 432 myeloma patients the serum M-protein doubling time at first relapse was meas...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1996.tb01371.x

    authors： Oivanen TM

    更新日期：1996-09-01 00:00:00

  • Allogeneic hematopoietic cell transplantation for paroxysmal nocturnal hemoglobinuria.

    abstract：BACKGROUND:Although allogeneic hematopoietic cell transplantation (HCT) has a potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), appropriate indication and conditioning regimen for HCT have not been established. PATIENTS AND METHODS:Between July 1999 and December 2001, five patients with PNH un...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1034/j.1600-0609.2003.00097.x

    authors： Lee JL,Lee JH,Lee JH,Choi SJ,Kim S,Seol M,Lee YS,Chi HS,Park CJ,Kim WK,Lee JS,Lee KH

    更新日期：2003-08-01 00:00:00