Cytoskeletal regulation of chemotactic receptors: molecular complexation of N-formyl peptide receptors with G proteins and actin.

abstract：:The presence of CD25 and HC2 antigens in 66 different patients with acute myeloid leukemia (AML) was investigated. The expression of both antigens was observed in 32% of AML cells. Dual fluorescence staining experiments performed in 5 AML patient cells showed that CD25 and HC2 antigens were simultaneously expressed in...

journal_title：European journal of haematology

authors： Padrós MR,Salamone MC,Zunszain PA,Fainboim L

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:For transplantation of cord blood (CB) cells, it is important to select a CB sample that can reconstitute not only myelo-erythropoiesis but also lymphopoiesis in recipients. However, until now the reconstitution ability of CB samples has been assessed by colony forming unit-culture (CFU-C) assay or by simply ...

journal_title：European journal of haematology

authors： Kato M,Masuda K,Kakugawa K,Kawamoto H,Mugishima H,Katsura Y

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:Invasive Aspergillosis (IA) is a serious problem among hematological patients and it is associated with high mortality. This situation can worsen at times of hospital construction, however there are several preventive measures available. This work aims to define the cost-effectiveness of some of these interv...

journal_title：European journal of haematology

authors： Combariza JF,Toro LF,Orozco JJ,Arango M

更新日期：2018-02-01 00:00:00

abstract：:During the period 1978-1982 in the three northernmost countries of Sweden all 143 patients with a registered diagnosis of chronic lymphocytic leukemia (CLL) were retrospectively analyzed. After re-evaluation, 122 cases remained in the study. The mean age was 71 years and the male/female ratio was 2.2:1. Sixty-one pati...

journal_title：European journal of haematology

authors： Erlanson M,Osterman B,Jonsson H,Lenner P

更新日期：1994-02-01 00:00:00

abstract：:We tested the immunosuppressive effect of cord blood (CB) natural killer (NK) cells using highly purified CB NK cells in mixed lymphocyte cultures (MLC) containing autologous CB T cells as responders. Control cultures were done without NK cells. Our findings revealed that CB NK cells induced a dose-dependent inhibitio...

journal_title：European journal of haematology

authors： El Marsafy S,Dosquet C,Coudert MC,Bensussan A,Carosella E,Gluckman E

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVES:Clonal dominance is characteristic of patients with post-polycythemia vera myelofibrosis (post-PV MF), whereas patients in chronic phase usually display polyclonal hematopoiesis. The aim of this work was to study the mutational burden of JAK2V617F at the progenitor level in patients with PV and correlate it ...

journal_title：European journal of haematology

authors： Angona A,Alvarez-Larrán A,Bellosillo B,Martínez-Avilés L,Camacho L,Fernández-Rodríguez C,Pairet S,Longarón R,Ancochea Á,Senín A,Florensa L,Besses C

更新日期：2015-03-01 00:00:00

abstract：:Alkaline phosphatase (ALP) activity of 70 cases of non-Hodgkin's lymphomas of the B-cell type was studied. ALP activity was found in malignant lymphoma (ML), follicular, small cleaved cell (1/5 cases); ML, diffuse, small cleaved cell (3/13 cases); and mantle zone lymphoma (intermediate lymphocytic lymphoma) (2/2 cases...

journal_title：European journal of haematology

authors： Abe M,Nozawa Y,Wachi E,Tominaga K,Hojo H,Wakasa H

更新日期：1988-09-01 00:00:00

abstract：:Although acute myeloid leukemia (AML) mostly occurs in older patients, it could be seen in women of childbearing age. It is therefore not surprising that in some patients the management of AML will be complicated by a coexistent pregnancy. However, the association of leukemia and pregnancy is uncommon. Its incidence i...

journal_title：European journal of haematology

authors： Thomas X

更新日期：2015-02-16 00:00:00

abstract：:A consecutive material of 111 untreated patients with non-Hodgkin's lymphoma was studied with respect to fraction of S-phase cells in blood mononuclear cells in relation to presence of monoclonal B cells in blood (MBCB). Fraction of S-phase cells was determined by flow cytometry and estimation of MBCB was performed by...

journal_title：European journal of haematology

authors： Lindh J,Jonsson H,Lenner P,Roos G

更新日期：1989-04-01 00:00:00

abstract：:15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B-cell phenotype different from that of B-CLL was observed (CD10-, CD19+, CD20+, CD21-, CD22+, CD37+, CD38-, FMC7+, LN1+, PCA-1+, BLy7+ and CD5-). As expected, CD11c and CD25 were positive and, in addition, a My7...

journal_title：European journal of haematology

authors： Hassan IB,Hagberg H,Sundström C

更新日期：1990-09-01 00:00:00

abstract：:We have studied the kinetics of plasma levels of circulating (c)selectins in 8 patients undergoing bone marrow or stem cell transplantation to gain estimates for the distribution and half-life of (c)selectins and to potentially identify an endothelial source of cP-selectin in patients who are deprived of platelets and...

journal_title：European journal of haematology

authors： Jilma B,Eichler HG,Becherer A,Brugger S,Kalhs P,Stohlawetz P,Kapiotis S,Kapiotis S

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:Warfarin represents the most commonly prescribed oral anticoagulants, which functions as an antagonist of vitamin K, an essential factor of blood coagulation cascade. Warfarin has a narrow therapeutic index. An insufficient dose can cause failure of antithrombotic effect, and an overdose increases a risk of b...

journal_title：European journal of haematology

authors： Krajčíová L,Petrovič R,Déžiová L,Chandoga J,Turčáni P

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Lower risk myelodysplastic syndromes (MDSs) are characterised by increased apoptosis of haematopoietic cells in the bone marrow (BM). The mechanism driving this excessive apoptosis involves multiple immune molecules, including inflammatory cytokines such as interferon-γ (IFN-γ), tumour necrosis factor-α (T...

journal_title：European journal of haematology

authors： Zhang Z,Li X,Guo J,Xu F,He Q,Zhao Y,Yang Y,Gu S,Zhang Y,Wu L,Chang C

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Disseminated adenovirus (AdV) infections following allogeneic stem cell transplantation (allo-SCT) are increasingly recognised, particularly in children. This study evaluated the clinical relevance of disseminated AdV infections in adult allo-SCT recipients, after different conditioning regimens. METHODS:In...

journal_title：European journal of haematology

authors： Kalpoe JS,van der Heiden PL,Barge RM,Houtzager S,Lankester AC,van Tol MJ,Kroes AC

更新日期：2007-04-01 00:00:00

abstract：:Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum...

journal_title：European journal of haematology

authors： Schaer DJ,Schleiffenbaum B,Kurrer M,Imhof A,Bächli E,Fehr J,Moller HJ,Moestrup SK,Schaffner A

更新日期：2005-01-01 00:00:00

abstract：:Administration of both glycosylated and non-glycosylated recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) induces an immediate transient granulocytopenia of 1-3 hours' duration. In order to explore this phenomenon, granulocytes were labelled with 111Indium and the effect on the kinetics of...

journal_title：European journal of haematology

authors： Hovgaard D,Schifter S,Rabøl A,Mortensen BT,Nissen NI

更新日期：1992-04-01 00:00:00

abstract：:Plasma and cellular pharmacokinetics of m-AMSA were investigated in 5 patients with acute leukemia, using HPLC. The pharmacokinetic data served as a guideline for in vitro toxicity tests on clonogenic bone marrow cells. m-AMSA was administered as a 3-hour intravenous infusion of 100 mg/m2. Median plasma and nucleated ...

journal_title：European journal of haematology

authors： Linssen P,Brons P,Knops G,Wessels H,de Witte T

更新日期：1993-03-01 00:00:00

abstract：:A case of hemoglobin H disease in combination with hemoglobin Constant Spring and a beta-globin chain variant is reported in a 3-yr-old Thai girl. On routine cellulose acetate electrophoresis, one abnormal band in addition to the hemoglobins A, A2, H, Bart's and Constant Spring was detected. The amount of this abnorma...

journal_title：European journal of haematology

authors： Fucharoen S,Ayukarn K,Sanchaisuriya K,Fucharoen G

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVES:Iron-overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. However, the precise mechanisms of iron entry and sequestration in the heart are still unclear. Our previous study showed that Fe(2+) uptake in thalassemic cardiomyocytes are mainly mediated by T-type calci...

journal_title：European journal of haematology

authors： Kumfu S,Chattipakorn S,Chinda K,Fucharoen S,Chattipakorn N

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To describe a case of venlafaxine-induced ecchymoses. METHODS:A patient with a history of ecchymoses coincident with venlafaxine therapy was rechallenged with the drug. Her platelet function was assessed with aggregation and ATP release studies before the rechallenge and after she developed ecchymoses. In ad...

journal_title：European journal of haematology

authors： Sarma A,Horne MK 3rd

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:As new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care. METHODS:We used the population-based Swedish ALL Registry to evaluate characteristics, treatment and long-term outcome in 933 patients with diagnosis between 1997 an...

journal_title：European journal of haematology

authors： Lennmyr E,Karlsson K,Ahlberg L,Garelius H,Hulegårdh E,Izarra AS,Joelsson J,Kozlowski P,Moicean A,Tomaszewska-Toporska B,Lübking A,Hallböök H,Swedish Adult Acute Lymphoblastic Leukaemia Group (SVALL).

更新日期：2019-08-01 00:00:00

abstract：:Human red blood cells (RBC) are heterogeneous with respect to their size; the physiological significance of this heterogeneity has not yet been fully elucidated. To further investigate this problem, some characteristics of human RBC fractionated according to their mean corpuscular volume (MCV) by counterflow centrifug...

journal_title：European journal of haematology

authors： Vaysse J,Gattegno L,Pilardeau P

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:To correlate different polymorphisms of the beta-globin cluster with fetal hemoglobin (HbF) level in beta-thalassemia and E-beta thalassemia patients. METHODS:Fifteen thalassemia patients, seven with high HbF and not requiring transfusion, eight with lower HbF and requiring transfusion were studied for beta-...

journal_title：European journal of haematology

authors： Bandyopadhyay S,Mondal BC,Sarkar P,Chandra S,Das MK,Dasgupta UB

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:To assess the molecular basis of phenotypic heterogeneity in north Indian patients with thalassemia major (TM). METHODS:To determine the clinical severity, 130 patients of TM were studied for the age of first presentation and frequency of blood transfusion. The type of beta mutations, Xmn-1(G)gamma polymorp...

journal_title：European journal of haematology

authors： Sharma N,Das R,Kaur J,Ahluwalia J,Trehan A,Bansal D,Panigrahi I,Marwaha RK

更新日期：2010-06-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder of the hematopoietic stem cell that makes blood cells more sensitive to the action of complement. Patients experience intravascular hemolysis, smooth muscle dystonia, renal failure, arterial and pulmonary hypertension, recurrent infectious diseases and ...

journal_title：European journal of haematology

authors： Devalet B,Mullier F,Chatelain B,Dogné JM,Chatelain C

更新日期：2015-09-01 00:00:00

abstract：:Beta-thalassaemia is characterised by progressive anaemia necessitating regular blood transfusions to sustain life. With the advent of effective chelating agents that can reduce the iron burden and extend patients' survival, renal disease, as in other ageing populations, has become more prevalent. In recent years, chr...

journal_title：European journal of haematology

authors： Bhandari S,Galanello R

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The clinical severity in thalassaemia major (TM) depends on the underlying mutations of the beta-globin gene and the degree of iron overload. OBJECTIVE:The aim of the study was to investigate the impact of genotype on the development of endocrine complications in TM in our center. SUBJECTS AND METHODS:126 ...

journal_title：European journal of haematology

authors： Skordis N,Michaelidou M,Savva SC,Ioannou Y,Rousounides A,Kleanthous M,Skordos G,Christou S

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Interferon-alpha (IFNalpha) was the first effective pharmacologic treatment of hairy cell leukemia (HCL). Since 1990 purine analogs replaced IFNalpha because of higher rates of complete remission and an invariable disease recurrence after cessation of IFNalpha. However, there are only limited data about long-...

journal_title：European journal of haematology

authors： Benz R,Siciliano RD,Stussi G,Fehr J

更新日期：2009-03-01 00:00:00

abstract：:33 patients with advanced refractory multiple myeloma received a combination of vincristine, cyclophosphamide, carmustine, melphalan and steroids (M-2 protocol). 20 of them had failed prior chemotherapy with alkylating agents and the remaining 13 patients had relapsed after a response to these drugs. An objective tumo...

journal_title：European journal of haematology

authors： Cavo M,Galieni P,Tassi C,Gobbi M,Tura S

更新日期：1988-02-01 00:00:00

abstract：OBJECTIVES:An aberrant pattern of expression of L-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34+ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML). METHODS:In a three-colour flow cytometric assay, we evaluated the expression of L-selectin and ICA...

journal_title：European journal of haematology

authors： Buccisano F,Maurillo L,Tamburini A,Del Poeta G,Del Principe MI,Ammatuna E,Consalvo MI,Campagna S,Ottaviani L,Sarlo C,Renzi D,Faccia S,Fraboni D,Lo Coco F,Amadori S,Venditti A

更新日期：2008-02-01 00:00:00