Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes.

abstract：:Effective iron chelation therapy is an important part of treatment in patients with transfusion-dependent thalassaemia and lower-risk myelodysplastic syndromes (MDS). Key strategies for optimising iron chelation therapy include ensuring good adherence and preventing and managing adverse events (AEs). Good adherence to...

journal_title：European journal of haematology

authors： Kattamis A,Aydinok Y,Taher A

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Non-Hodgkin lymphoma patients have a 25% increased risk of secondary primary neoplasms (SPNs). Regarding the controversy about the increased risk of SPN in patients exposed to radioimmunotherapy (RIT), we have analyzed this issue in a cohort of follicular lymphoma (FL) patients treated with/without RIT. PAT...

journal_title：European journal of haematology

authors： Andrade-Campos MM,Liévano P,Espinosa-Lara N,Soro-Alcubierre G,Grasa-Ulrich JM,López-Gómez L,Baringo T,Giraldo P

更新日期：2016-12-01 00:00:00

abstract：:Immune thrombocytopenic purpura (ITP) is an autoimmune disorder, and high-dose dexamethasome (HD-DXM) has been used as a first-line therapy for patients with ITP. However, little is known about the role of dendritic cells (DCs) and CD4(+)Foxp3(+) regulatory T (Treg) cells in the pathogenesis of chronic ITP and the eff...

journal_title：European journal of haematology

authors： Ling Y,Cao X,Yu Z,Ruan C

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Since a study published in 2002 showed a survival advantage of melphalan-only conditioning for stem cell transplantation (HSCT) over melphalan-total body irradiation (mel-TBI) in patients with multiple myeloma (MM), most centers abandoned mel-TBI. Mel-TBI causes more early toxicity and is more...

journal_title：European journal of haematology

authors： Munker R,Baghian A,Koleva Y,Andrews P,Matharoo GS,Wright AE,Saba NS,Weiner RS,Safah H

更新日期：2017-07-01 00:00:00

abstract：:It is well-known that uremic patients present prolonged bleeding times as a common complication. Factors responsible for this disorder have been extensively investigated. In order to elucidate the possible role of uremic middle molecules as responsible for the bleeding tendency observed in uremia, we have studied the ...

journal_title：European journal of haematology

authors： Palés JL,López A,Asensio A,Merola E,Company X,Deulofeu R,Garcia M,Balagué A

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVES:Mantle cell lymphoma (MCL) is an incurable disease with an aggressive course and novel treatment strategies are urgently needed. The purpose of this study was to evaluate the effects of histone deacetylase (HDAC) inhibitors, a new group of antiproliferative agents, on human MCL cells. METHODS:Three MCL cell...

journal_title：European journal of haematology

authors： Heider U,Kaiser M,Sterz J,Zavrski I,Jakob C,Fleissner C,Eucker J,Possinger K,Sezer O

更新日期：2006-01-01 00:00:00

abstract：:Several plasma cells morphological changes have been described in monoclonal gammopathies, including intracytoplasmic crystals. We report one case of indolent kappa-chain multiple myeloma with renal insufficiency, featuring plasma cells with Auer-rod-like intracytoplasmic inclusions. The relationship between such aber...

journal_title：European journal of haematology

authors： Gardais J,Geneviève F,Foussard C,Delisle V,Zandecki M

更新日期：2001-08-01 00:00:00

abstract：:Although cladribine has been reported to be an active purine analog against indolent B-cell non-Hodgkin lymphoma (B-NHL), there are few reports of combination use of cladribine and rituximab. This multicenter phase II study evaluated the efficacy and toxicity of cladribine with rituximab (R-2-CdA) therapy in relapsed ...

journal_title：European journal of haematology

authors： Nagai H,Ogura M,Kusumoto S,Takahashi N,Yamaguchi M,Takayama N,Kinoshita T,Motoji T,Ohyashiki K,Kosugi H,Matsuda S,Ohnishi K,Omachi K,Hotta T

更新日期：2011-02-01 00:00:00

abstract：:A 1-yr-old Japanese male infant developed hepatitis-associated aplastic anemia (AA), and anti-thymocyte globulin (ATG) plus cyclosporine A (CsA) was administered without any appreciable effects. Laboratory examination of the patient's serum obtained before therapy revealed various autoantibodies, such as PA-IgG, anti-...

journal_title：European journal of haematology

authors： Takamatsu H,Yagasaki H,Takahashi Y,Hama A,Saikawa Y,Yachie A,Koizumi S,Kojima S,Nakao S

更新日期：2011-06-01 00:00:00

abstract：:An automated reticulocyte counter using flowcytometric analysis, the R-3000 (Sysmex Inc. Kobe, Japan), has recently been modified to determine reticulated platelets (RPs) and large platelets (LPs). We measured frequencies of RPs, LPs in total platelet count and serum thrombopoietin concentration comprehensively in non...

journal_title：European journal of haematology

authors： Koh KR,Yamane T,Ohta K,Hino M,Takubo T,Tatsumi N

更新日期：1999-11-01 00:00:00

abstract：:Kostmann syndrome (KS) is an inherited hematological disorder characterized by an absolute neutrophil count (ANC) <0.2 x 109/L and life-threatening bacterial infections. Granulocyte-colony stimulating factor (G-CSF) makes it possible to reach an ANC of 1.0 x 109/L and consequently to reduce significantly the occurrenc...

journal_title：European journal of haematology

authors： Dallorso S,Manzitti C,Dodero P,Faraci M,Rosanda C,Castagnola E

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:Primary and post-ET/PV myelofibrosis are myeloproliferative neoplasms harboring in most cases driving mutations in JAK2, CALR or MPL, and a variable number of additional mutations in other genes. Molecular analysis represents a powerful tool to guide prognosis and clinical management. Only about 10% of pat...

journal_title：European journal of haematology

authors： Mannina D,Gagelmann N,Badbaran A,Ditschkowski M,Bogdanov R,Robin M,Cassinat B,Heuser M,Shahswar R,Thol F,Beelen D,Kröger N

更新日期：2019-12-01 00:00:00

abstract：:33 patients with advanced refractory multiple myeloma received a combination of vincristine, cyclophosphamide, carmustine, melphalan and steroids (M-2 protocol). 20 of them had failed prior chemotherapy with alkylating agents and the remaining 13 patients had relapsed after a response to these drugs. An objective tumo...

journal_title：European journal of haematology

authors： Cavo M,Galieni P,Tassi C,Gobbi M,Tura S

更新日期：1988-02-01 00:00:00

abstract：:The heat production rate in peripheral blood lymphocytes was evaluated by direct calorimetry in 76 untreated adults with non-Hodgkin's lymphoma (NHL). Elevated values were recorded for 20 out of 54 patients with lymphomas of high or intermediate malignancy grade (37%) and for 1 out of 22 patients (5%) with low grade l...

journal_title：European journal of haematology

authors： Monti M,Brandt L,Ikomi-Kumm J,Olsson H

更新日期：1990-11-01 00:00:00

abstract：:Fludarabine is frequently used for treatment of B-cell chronic lymphocytic leukemia and in conditioning regimes for hematopoietic cell transplantations. The total body clearance of the principal metabolite 2-fluoro-ara-A (2F-Ara-A) correlates with the creatinine clearance. We report data on total dialysate concentrati...

journal_title：European journal of haematology

authors： Kielstein JT,Stadler M,Czock D,Keller F,Hertenstein B,Radermacher J

更新日期：2005-06-01 00:00:00

abstract：:Vertical and horizontal interactions between membrane constituents account for integrity, strength and deformability of the erythrocyte. Disruption of vertical interactions caused by membrane protein deficiencies in hereditary spherocytosis (HS), favor membrane vesiculation with development of spherocytic cells. Our a...

journal_title：European journal of haematology

authors： Rocha S,Rebelo I,Costa E,Catarino C,Belo L,Castro EM,Cabeda JM,Barbot J,Quintanilha A,Santos-Silva A

更新日期：2005-05-01 00:00:00

abstract：:Langerhans cells originate in bone marrow and probably belong to the monocyte-macrophage lineage. CD1 is a specific marker of Langerhans cells. By immunofluorescence and immunoelectron microscopy, CD1a antigen and myeloid markers (CD11, CD13, CD14, CD15, CD33, HLA-DR) were studied in 53 cases of acute myeloid leukemia...

journal_title：European journal of haematology

authors： Misery L,Campos L,Dezutter-Dambuyant C,Guyotat D,Treille D,Schmitt D,Thivolet J

更新日期：1992-01-01 00:00:00

abstract：:The candidate tumour suppressor gene MMAC1/PTEN located at chromosome 10q23.3 has been reported to be frequently mutated in a number of solid tumours. Less is known about its status in leukaemia. In the present study we first analysed 13 leukaemia cell lines for mutations and homozygous deletions in MMAC1/PTEN using P...

journal_title：European journal of haematology

authors： Aggerholm A,Grønbaek K,Guldberg P,Hokland P

更新日期：2000-08-01 00:00:00

abstract：:We demonstrate the in vivo effects of bacterially synthesized, N-methionine-free recombinant human granulocyte-macrophage colony stimulating factor (rh GM-CSF) using a crab-eating monkey model. Monkeys were treated with cyclophosphamide (60 mg/kg) and administered with rh GM-CSF (30 micrograms/kg/d) subcutaneously (s....

journal_title：European journal of haematology

authors： Akashi K,Taniguchi S,Teshima T,Shibuya T,Okamura T,Harada M,Niho Y

更新日期：1990-02-01 00:00:00

abstract：:Chronic isolated hereditary macrothrombocytopenia (CHMT) is a congenital form of macrothrombocytopenia that seems to be due to defective production secondary to a disturbance in megakaryocyte fragmentation. To better understand the pathogenesis of thrombopoiesis in this hereditary thrombocytopenic disorder, we determi...

journal_title：European journal of haematology

authors： Fabris F,Cordiano I,Steffan A,Ramon R,Scandellari R,Nichol JL,Girolami A

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Infections remain a leading cause of morbidity and mortality in patients with reduced immunity caused by haematological disease and chemotherapy-induced neutropenia. We evaluated the clinical and microbiological impact of discontinuing fluoroquinolone prophylaxis in these patients. METHODS:We analysed 154 a...

journal_title：European journal of haematology

authors： Verlinden A,Jansens H,Goossens H,van de Velde AL,Schroyens WA,Berneman ZN,Gadisseur AP

更新日期：2014-10-01 00:00:00

abstract：:T-cell lymphoma is an aggressive lymphoma that cannot be cured despite aggressive therapy, including autologous stem cell transplantation. Thalidomide is an immunomodulatory drug with numerous properties that has proven effective in relapsed multiple myeloma and, to a lesser extent, in other hematologic diseases. We r...

journal_title：European journal of haematology

authors： Damaj G,Bouabdallah R,Vey N,Bilger K,Mohty M,Gastaut JA

更新日期：2005-02-01 00:00:00

abstract：:While cellular modulation in vitro of committed hematopoietic stem cell (HSC) growth has been known for some time, less is known about the effect of accessory cells (AC) on the growth of more immature HSC. We have examined the effect of peripheral blood (PB) AC on hematopoiesis by coculturing enriched PB CD34+ cells (...

journal_title：European journal of haematology

authors： Olesen G,Tønder H,Palshof T,Hokland P

更新日期：2002-02-01 00:00:00

abstract：:Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the co...

journal_title：European journal of haematology

authors： Tsutsumi Y,Tanaka J,Kanamori H,Musashi M,Minami H,Fukushima A,Yamato H,Ehira N,Kawamura T,Obara S,Ogura N,Asaka M,Imamura M,Masauzi N

更新日期：2004-12-01 00:00:00

abstract：:The introduction of novel immunomodulatory drugs (IMiDs) has dramatically improved the survival of patients with multiple myeloma (MM). While it has been shown that patients with specific cytogenetic subtypes, namely t(4;14), have the best outcomes when treated with bortezomib-based regimens, the relationship between ...

journal_title：European journal of haematology

authors： Greenberg AJ,Walters DK,Kumar SK,Rajkumar SV,Jelinek DF

更新日期：2013-12-01 00:00:00

abstract：AIMS:Platelets retain cytoplasmic messenger RNA and are capable of protein biosynthesis. Several diseases are known to impact the platelet transcriptome but the effect of non-valvular atrial fibrillation (NVAF) on platelet RNA transcript is essentially unknown. The aim of this study was to evaluate the impact of NVAF o...

journal_title：European journal of haematology

authors： Wysokinski WE,Tafur A,Ammash N,Asirvatham SJ,Wu Y,Gosk-Bierska I,Grill DE,Slusser JP,Mruk J,McBane RD

更新日期：2017-06-01 00:00:00

abstract：:We reviewed the indications for and the results of bone marrow examination (BME) from HIV-infected patients as an attempt to improve its diagnostic yield. One-hundred-and-eight bone marrow specimens from 90 patients during a 3-year period were examined. A cytological, histological and microbiological study was carried...

journal_title：European journal of haematology

authors： Ciaudo M,Doco-Lecompte T,Guettier C,d'Agay MF,David F,Rioual N,Buu-Hoi A,Molina JM,Kazatchkine M,Modai J

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:MicroRNAs engaged in angiogenesis and hematopoiesis can influence hematopoietic stem cells (HSCs) homing after transplantation by targeting bone marrow niche microenvironment. This study aimed to examine the kinetics of miRNA-15a, miRNA-16, miRNA-126, miRNA-146a, and miRNA-223 in autologous HSC transplantatio...

journal_title：European journal of haematology

authors： Nowicki M,Szemraj J,Wierzbowska A,Misiewicz M,Małachowski R,Pluta A,Grzybowska-Izydorczyk O,Robak T,Szmigielska-Kapłon A

更新日期：2018-05-01 00:00:00

abstract：:MYH9 disorders are autosomal dominant macrothrombocytopenias with leukocyte inclusion bodies. Single point mutations in the protein-coding sequence of the MYH9 gene are the most common cause. So far no large gene deletion/insertion and splicing defects have been reported. Conventional DNA sequencing of each MYH9-codin...

journal_title：European journal of haematology

authors： Kunishima S,Matsushita T,Hamaguchi M,Saito H

更新日期：2008-06-01 00:00:00

abstract：:Whereas beta-2-microglobulin (beta2M) has mainly been used as a prognostic factor in patients with lymphoproliferative disorders, some studies have reported the value of beta2M in myeloproliferative disorders (MPD). In order to investigate a potential role in the pathogenesis of MPD and to find a possible value as ind...

journal_title：European journal of haematology

authors： Bourantas KL,Hatzimichael EC,Makis AC,Chaidos A,Kapsali ED,Tsiara S,Mavridis A

更新日期：1999-07-01 00:00:00