当前位置： SCI文献检索 > EUROPEAN JOURNAL OF HAEMATOLOGY期刊下所有文献 > Cladribine combined with rituximab (R-2-CdA) therapy is an effective salvage therapy in relapsed or refractory indolent B-cell non-Hodgkin lymphoma.

Cladribine combined with rituximab (R-2-CdA) therapy is an effective salvage therapy in relapsed or refractory indolent B-cell non-Hodgkin lymphoma.

Abstract：

:Although cladribine has been reported to be an active purine analog against indolent B-cell non-Hodgkin lymphoma (B-NHL), there are few reports of combination use of cladribine and rituximab. This multicenter phase II study evaluated the efficacy and toxicity of cladribine with rituximab (R-2-CdA) therapy in relapsed or refractory indolent B-NHL. Twenty patients with the median age of 58.5 yrs (range, 42-72) were enrolled and received R-2-CdA therapy from April 2005 to July 2007. The median number of prior regimens was 2 (range, 1-3), and fifteen patients (75%) were previously treated with rituximab-containing regimens. Disease histology included follicular lymphoma in 16 patients, MALT lymphoma in two patients, nodal marginal B-cell lymphoma in one patient, and lymphoplasmacytic lymphoma in one patient. The overall response rate (ORR) was 90%, with a complete response rate (CRR) of 70%. Estimated median progression-free survival (PFS) time was 22.4 months (95%CI, 10.9-32.6 months) at a median follow-up time of 27 months (range, 12-43). Two-year PFS and 2-yr overall survival (OS) were 52.6% (95%CI, 31.0-73.2%) and 89.5% (95%CI, 66.1-97.3%), respectively. Grade 3 or grade 4 toxicities were neutropenia in 74% and thrombocytopenia in 11%. R-2-CdA therapy was demonstrated to have a high activity with durable PFS and acceptable toxicity in relapsed or refractory indolent B-NHL mostly pretreated with rituximab-containing therapy. Although a large-scale trial is needed for confirmation, R-2-CdA therapy could be a good salvage therapy option in relapsed or refractory indolent B-NHL.

journal_name

Eur J Haematol

journal_title

European journal of haematology

authors

Nagai H,Ogura M,Kusumoto S,Takahashi N,Yamaguchi M,Takayama N,Kinoshita T,Motoji T,Ohyashiki K,Kosugi H,Matsuda S,Ohnishi K,Omachi K,Hotta T

doi

10.1111/j.1600-0609.2010.01552.x

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

117-23

issue

2

eissn

0902-4441

issn

1600-0609

journal_volume

86

pub_type

杂志文章,多中心研究

相关文献

EUROPEAN JOURNAL OF HAEMATOLOGY文献大全
  • Vacuoles in red cells from splenectomized subjects originate during cell life: association with glycosylated haemoglobin?

    abstract：:Whole blood from splenectomized subjects (n = 8) contained a substantial percentage of vacuolated ('pitted') red cells (34.7 +/- 8.3%), while blood from controls revealed none. The percentage of haemoglobin A1 (HbA1) had increased significantly compared with controls (p less than 0.01). Fractionation on cell density r...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1988.tb00231.x

    authors： De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

    更新日期：1988-11-01 00:00:00

  • Response rate and survival after conventional chemotherapy for multiple myeloma by hospitals with different inclusion rates of patients to the trials. A Finnish Leukemia Group study.

    abstract：:The purpose of this study was to analyse the influence of the hospital size, measured as the number of annual patient enrolments in the Finnish Leukaemia Group trials in the period 1979-85, on response rate and survival after conventional chemotherapy for multiple myeloma. The 432 myeloma patients for this study were ...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/j.1600-0609.1999.tb01882.x

    authors： Oivanen T,Kellokumpu-Lehtinen P,Koivisto AM,Koivunen E

    更新日期：1999-10-01 00:00:00

  • Treating Secondary Antibody Deficiency in Patients with Haematological Malignancy: European Expert Consensus.

    abstract：OBJECTIVES:Secondary antibody deficiency (SAD), associated with severe, recurrent or persistent infections, is common in patients with haematological malignancies (HM), but unifying guidance on immunoglobulin replacement therapy (IgRT) in these patients is lacking. We aimed to develop consensus statements for the use o...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/ejh.13580

    authors： Jolles S,Michallet M,Agostini C,Albert MH,Edgar D,Ria R,Trentin L,Lévy V

    更新日期：2021-01-16 00:00:00

  • Clinical results according to age in patients with chronic myeloid leukemia receiving imatinib frontline: The younger, the later, the worse?

    abstract：OBJECTIVES:To evaluate differences in clinical results according to age among patients with chronic myeloid leukemia (CML). METHODS:207 consecutive CML patients treated with imatinib frontline were revised, dividing them in young adults (>20 < 45 years) (YA), middle-aged adults (≥45 < 65 years) (MA) and elderly (≥65 y...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.13110

    authors： Latagliata R,Breccia M,Carmosino I,Cesini L,De Benedittis D,Mohamed S,Vozella F,Molica M,Campanelli M,De Luca ML,Colafigli G,Quattrocchi L,Loglisci MG,Massaro F,Canichella M,Diverio D,Mancini M,Alimena G,Foà R

    更新日期：2018-06-13 00:00:00

  • Socioeconomic burden of participation in clinical trials in patients with myeloproliferative neoplasms.

    abstract：OBJECTIVE:To determine the financial and psycho-social impact of participation in clinical trials of patients with BCR/ABL-negative myeloproliferative neoplasms (MPN). METHODS:An international, observational cross-sectional study was performed in 143 consecutive MPN patients (51% myelofibrosis, 36% polycythemia vera, ...

    journal_title：European journal of haematology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/ejh.12887

    authors： Goel S,Paoli C,Iurlo A,Pereira A,Efficace F,Barbui T,Tefferi A,Vannucchi AM,Cervantes F

    更新日期：2017-07-01 00:00:00

  • Reticulocyte crisis after splenectomy: evidence for delayed red cell maturation?

    abstract：:In whole blood from splenectomized subjects (n = 8) in a steady state an increased number of reticulocytes was observed (14.0 +/- 7.8% versus 3.6 +/- 2.4% controls: p less than 0.05). Cell fractionation on density showed that reticulocytes, as in normals, are more or less confined to the least dense fraction; cell fra...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1988.tb00872.x

    authors： De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

    更新日期：1988-07-01 00:00:00

  • Antifungal therapy in patients with hematological malignancies: how to avoid overtreatment?

    abstract：UNLABELLED:Historically, treatment of invasive fungal infections (IFI) has consisted of amphotericin B. However, new therapeutic agents have recently been introduced. At the same time, the relatively low incidence of IFI and the progress in the diagnostic accuracy of IFI have made routine use of empirical antifungal th...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2006.00712.x

    authors： Cherif H,Kalin M,Björkholm M

    更新日期：2006-10-01 00:00:00

  • Gene probe analysis demonstrates independent clonal evolution of co-existent chronic myeloid and chronic lymphocytic leukaemia.

    abstract：:We describe a case of Philadelphia-positive chronic myeloid leukaemia occurring simultaneously with B-cell chronic lymphocytic leukaemia in a 69-yr-old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominan...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1988.tb00818.x

    authors： Browett PJ,Pattinson J,Pinkney J,Hoffbrand AV,Norton JD

    更新日期：1988-02-01 00:00:00

  • Splenectomy in patients with malignant lymphoma presenting with massive splenomegaly.

    abstract：:6 patients with massive splenomegaly but no peripheral adenopathy were diagnosed by splenectomy as having lymphoma; and were found to have widespread disease. Despite the seriousness of their illness at presentation, all have survived for a median time of 101.5 months and reached complete remission. ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1987.tb01156.x

    authors： King DJ,Dawson AA,Thompson WD

    更新日期：1987-02-01 00:00:00

  • Circulating dendritic cells subsets and CD4+Foxp3+ regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome.

    abstract：:Immune thrombocytopenic purpura (ITP) is an autoimmune disorder, and high-dose dexamethasome (HD-DXM) has been used as a first-line therapy for patients with ITP. However, little is known about the role of dendritic cells (DCs) and CD4(+)Foxp3(+) regulatory T (Treg) cells in the pathogenesis of chronic ITP and the eff...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1600-0609.2007.00917.x

    authors： Ling Y,Cao X,Yu Z,Ruan C

    更新日期：2007-10-01 00:00:00

  • MDM2 SNP309 promoter polymorphism, an independent prognostic factor in chronic lymphocytic leukemia.

    abstract：BACKGROUND:The single nucleotide polymorphism SNP309 with a change from T to G in the promoter region of the MDM2 gene is shown to increase the MDM2 protein levels and attenuate the p53 levels and associates with disease progression in several tumors. OBJECTIVE:In this study, the role of the polymorphism was investiga...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2010.01470.x

    authors： Willander K,Ungerbäck J,Karlsson K,Fredrikson M,Söderkvist P,Linderholm M

    更新日期：2010-09-01 00:00:00

  • A comparison of fluorine-18 fluoro-deoxyglucose PET and technetium-99m sestamibi in assessing patients with multiple myeloma.

    abstract：OBJECTIVE:The extent of disease in patients with multiple myeloma or related conditions may be difficult to assess. In previous small studies, both FDG-PET (PET) and Tc-99m sestamibi scans (MIBI) have identified sites of occult disease in myeloma. METHODS:We reviewed the results for patients at our institution who hav...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.0902-4441.2004.00177.x

    authors： Mileshkin L,Blum R,Seymour JF,Patrikeos A,Hicks RJ,Prince HM

    更新日期：2004-01-01 00:00:00

  • FLAMSA reduced-intensity conditioning is equally effective in AML patients with primary induction failure as well as in first or second complete remission.

    abstract：:Reduced-intensity conditioning regimens have demonstrated lower toxicity but increased relapse rates in the context of allogeneic hematopoietic stem cell transplantation (aSCT) for patients with acute myelogenous leukemia (AML). The FLAMSA- reduced-intensity conditioning (RIC) regimen, combining a cytoreductive and a ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12615

    authors： Holtick U,Shimabukuro-Vornhagen A,Chakupurakal G,Theurich S,Leitzke S,Burst A,Hallek M,von Bergwelt-Baildon M,Scheid C,Chemnitz JM

    更新日期：2016-05-01 00:00:00

  • Leukocyte-depleted blood components prevent platelet refractoriness in patients with acute myeloid leukemia.

    abstract：:Platelet refractoriness arising from HLA immunization develops in 20-50% of multitransfused patients with hematologic malignancies. We retrospectively analyzed the efficiency of leukocyte-depleted blood components in preventing refractoriness in 140 adult patients with acute myeloid leukemia (AML), treated according t...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1994.tb01872.x

    authors： Oksanen K

    更新日期：1994-08-01 00:00:00

  • Feasibility of fludarabine added to VAD during induction therapy in multiple myeloma: a randomised phase II-study.

    abstract：:Multiple myeloma (MM) is considered to be an essentially incurable haematological malignant disease, probably because of the existence of resistant clonal precursor cell with self-renewal capacity. Recent data have indicated that the myeloma cell hierarchy includes circulating clonal memory B cells, which differ consi...

    journal_title：European journal of haematology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1034/j.1600-0609.2003.00068.x

    authors： Björkstrand B,Rasmussen T,Remes K,Gruber A,Pelliniemi TT,Johnsen HE

    更新日期：2003-06-01 00:00:00

  • On the interaction between cytosine arabinoside and etoposide in vivo and in vitro.

    abstract：:Cytosine arabinoside (ara-C) and etoposide are often used in combination in the treatment of acute myelocytic leukemia (AML). The intracellular phosphorylation of ara-C to its 5'-triphosphate (ara-CTP) is a prerequisite for its cytotoxic effects. It has been shown in vitro that etoposide can impair the formation of ar...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1993.tb00069.x

    authors： Liliemark J,Knochenhauer E,Gruber A,Pettersson B,Björkholm M,Peterson C

    更新日期：1993-01-01 00:00:00

  • Plasma cell leukemia: from biology to treatment.

    abstract：:Plasma cell leukemia (PCL) is a very aggressive and rare form of malignant monoclonal gammopathy characterized by the presence of plasmocytes in peripheral blood. It is classified as primary PCL occuring 'de novo', or as secondary PCL in patients with relapsed/refractory multiple myeloma. Primary PCL is a distinct cli...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/ejh.12533

    authors： Jelinek T,Kryukov F,Rihova L,Hajek R

    更新日期：2015-07-01 00:00:00

  • Whole blood folate values in pernicious anaemia: relation to treatment.

    abstract：:27 patients with pernicious anaemia, followed for a long period, were consecutively treated with three different vitamin B12 preparations, while during intervening period no therapy was given until signs of B12 deficiency developed. After vitamin B12 treatment, a peak whole blood folate value some 70% higher than the ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1987.tb00161.x

    authors： Magnus EM

    更新日期：1987-07-01 00:00:00

  • Porcine platelets in vitro and in vivo studies: relevance to human thrombosis research.

    abstract：:This review summarizes present knowledge on porcine platelets in vitro and recent studies on in vivo activation of platelets in the pig. There are certain differences compared to human platelets: Platelet aggregation and secretion cannot be achieved by epinephrine, and the arachidonate pathway seems poorly developed i...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.1992.tb00043.x

    authors： Søfteland E,Framstad T,Thorsen T,Holmsen H

    更新日期：1992-10-01 00:00:00

  • Leucopoiesis versus concentration of cytokines in diffusion chamber cultures of mouse bone marrow cells: clues to the physiological roles of growth factors.

    abstract：:Physiological mechanisms that regulate formation of neutrophil granulocytes, macrophages and their precursor cells were studied with the diffusion chamber (DC) technique. DC inoculated with mouse bone marrow cells were implanted intraperitoneally into host mice. When these in vivo cultures had been established and the...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1989.tb00245.x

    authors： Benestad HB,Løvhaug D,Strøm-Gundersen I

    更新日期：1989-01-01 00:00:00

  • The prognostic significance of cytogenetic aberrations in childhood acute myeloid leukaemia. A study of the Swiss Paediatric Oncology Group (SPOG).

    abstract：:In childhood-onset acute myeloid leukaemia (AML) the clinical value of karyotypic aberrations is now acknowledged, although there is still debate concerning the prognostic significance of some events. To add to this knowledge, cytogenetic analysis was performed on a consecutive series of 84 childhood AML patients diag...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2007.00854.x

    authors： Betts DR,Ammann RA,Hirt A,Hengartner H,Beck-Popovic M,Kuhne T,Nobile L,Caflisch U,Wacker P,Niggli FK

    更新日期：2007-06-01 00:00:00

  • Acute clinical events in 299 homozygous sickle cell patients living in France. French Study Group on Sickle Cell Disease.

    abstract：:A subset of 299 patients with homozygous sickle cell anaemia, enrolled in the cohort of the French Study Group on sickle cell disease (SCD), was investigated in this study. The majority of patients were children (mean age 10.1 +/- 5.8 yr) of first generation immigrants from Western and Central Africa, the others origi...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0609.2000.90210.x

    authors： Neonato MG,Guilloud-Bataille M,Beauvais P,Bégué P,Belloy M,Benkerrou M,Ducrocq R,Maier-Redelsperger M,de Montalembert M,Quinet B,Elion J,Feingold J,Girot R

    更新日期：2000-09-01 00:00:00

  • Primary pancreatic lymphoma: Clinical presentation, diagnosis, treatment, and outcome.

    abstract：:Primary pancreatic lymphoma (PPL) is a rare disease representing 0.1% of malignant lymphomas, which lacks well-defined diagnostic and therapeutic protocols. OBJECTIVES:To describe PPL clinical, diagnostic and histological characteristics, together with therapy and outcome, in a relatively large series of patients. M...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.13468

    authors： Facchinelli D,Sina S,Boninsegna E,Borin A,Tisi MC,Piazza F,Scapinello G,Maiolo E,Hohaus S,Zamò A,Merli M,Stefani PM,Mellone F,Basso M,Sartori R,Rusconi C,Parisi A,Manfrin E,Krampera M,Ruggeri M,Visco C,Tecchio C

    更新日期：2020-10-01 00:00:00

  • A novel mutation in a Turkish patient with Hermansky-Pudlak syndrome type 5.

    abstract：:The Hermansky-Pudlak syndrome (HPS) is a rare genetically heterogeneous autosomal recessive disorder, characterized by tyrosinase-positive oculocutaneous albinism, platelet dysfunction and lysosomal ceroid lipofuscin storage. This is caused by defects in lysosome-related organelles. In humans eight different types of ...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.2007.01024.x

    authors： Korswagen LA,Huizing M,Simsek S,Janssen JJ,Zweegman S

    更新日期：2008-04-01 00:00:00

  • Bone marrow biopsy in Hodgkin's lymphoma.

    abstract：:In the study of patients with Hodgkin's lymphoma (HL) the evaluation of bone marrow biopsy (BMB) can be difficult. In this review we analyze the main diagnostic features and the clinical risk factors of BM involvement. Although the role of BMB is criticized by some authors, its value is irreplaceable in the staging of...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0609.2004.00292.x

    authors： Franco V,Tripodo C,Rizzo A,Stella M,Florena AM

    更新日期：2004-09-01 00:00:00

  • Pathophysiological significance of simultaneous measurement of reticulated platelets, large platelets and serum thrombopoietin in non-neoplastic thrombocytopenic disorders.

    abstract：:An automated reticulocyte counter using flowcytometric analysis, the R-3000 (Sysmex Inc. Kobe, Japan), has recently been modified to determine reticulated platelets (RPs) and large platelets (LPs). We measured frequencies of RPs, LPs in total platelet count and serum thrombopoietin concentration comprehensively in non...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1999.tb01131.x

    authors： Koh KR,Yamane T,Ohta K,Hino M,Takubo T,Tatsumi N

    更新日期：1999-11-01 00:00:00

  • Hepatitis B virus infection is associated with deletion of chromosome 8p in multiple myeloma.

    abstract：:Serological analyses within epidemiological cohort and case-control studies indicate to an association between HBV infection and risk of multiple myeloma (MM). To verify the relationship with an independent approach, we investigated the correlation between HBV positivity and chromosomal aberrations within 680 patients...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12018

    authors： Becker N,Byl A,Friedrich S,Jauch A,Schnitzler P,Egerer G,Ho AD,Goldschmidt H,Neben K

    更新日期：2013-04-01 00:00:00

  • An Arg545----Cys545 substitution mutation of the von Willebrand factor in type IIB von Willebrand's disease.

    abstract：:Type IIB is a special variant of von Willebrand's disease, characterized by an abnormal von Willebrand factor which shows an increased interaction with platelets. This interaction sometimes causes platelet aggregation and thrombocytopenia in vivo. It involves the glycoprotein-Ib (GPIb) receptor on platelets and corres...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0609.1991.tb01858.x

    authors： Donnér M,Andersson AM,Kristoffersson AC,Nilsson IM,Dahlbäck B,Holmberg L

    更新日期：1991-11-01 00:00:00

  • Acute myeloid leukemia in the pregnant patient.

    abstract：:Although acute myeloid leukemia (AML) mostly occurs in older patients, it could be seen in women of childbearing age. It is therefore not surprising that in some patients, the management of AML will be complicated by a coexistent pregnancy. However, the association of leukemia and pregnancy is uncommon. Its incidence ...

    journal_title：European journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/ejh.12479

    authors： Thomas X

    更新日期：2015-08-01 00:00:00

  • Interleukin-17 enhances the production of interferon-γ and tumour necrosis factor-α by bone marrow T lymphocytes from patients with lower risk myelodysplastic syndromes.

    abstract：INTRODUCTION:Lower risk myelodysplastic syndromes (MDSs) are characterised by increased apoptosis of haematopoietic cells in the bone marrow (BM). The mechanism driving this excessive apoptosis involves multiple immune molecules, including inflammatory cytokines such as interferon-γ (IFN-γ), tumour necrosis factor-α (T...

    journal_title：European journal of haematology

    pub_type： 杂志文章

    doi：10.1111/ejh.12074

    authors： Zhang Z,Li X,Guo J,Xu F,He Q,Zhao Y,Yang Y,Gu S,Zhang Y,Wu L,Chang C

    更新日期：2013-05-01 00:00:00