Vacuoles in red cells from splenectomized subjects originate during cell life: association with glycosylated haemoglobin?

abstract：BACKGROUND:Limited progress had been made in prognostic stratification of patients with Hodgkin lymphoma (HL) until recent studies suggested that the number of CD68-expressing macrophages is prognostic in classical HL. However, its significance in Asian patients with HL has not been explored yet perhaps because of its ...

journal_title：European journal of haematology

authors： Yoon DH,Koh YW,Kang HJ,Kim S,Park CS,Lee SW,Suh C,Huh J

更新日期：2012-04-01 00:00:00

abstract：:In March 1981, a 53-year-old man presented with itching and was diagnosed as having myelofibrosis. There was gradual enlargement of the spleen over the following 5 yr. His spleen had to be removed in February 1986 because of physical discomfort. 3 months post-splenectomy he became polycythaemic. Bone marrow examinatio...

journal_title：European journal of haematology

authors： Dokal I,Pagliuca A,Deenmamode M,Mufti GJ,Lewis SM

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Although allogeneic hematopoietic cell transplantation (HCT) has a potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), appropriate indication and conditioning regimen for HCT have not been established. PATIENTS AND METHODS:Between July 1999 and December 2001, five patients with PNH un...

journal_title：European journal of haematology

authors： Lee JL,Lee JH,Lee JH,Choi SJ,Kim S,Seol M,Lee YS,Chi HS,Park CJ,Kim WK,Lee JS,Lee KH

更新日期：2003-08-01 00:00:00

abstract：:The oncogenes c-myc and c-ras are known to elicit a cooperative tumorigenicity. In this study we investigated their role in the pathogenesis of Hodgkin's disease. The expression of these oncogenes was determined in Hodgkin's disease patients by avidin-biotin peroxidase complex immunohistochemical staining and was comp...

journal_title：European journal of haematology

authors： Benharroch D,Yermiahu T,Geffen DB,Prinsloo I,Gopas J,Segal S,Aboud M

更新日期：1995-09-01 00:00:00

abstract：:Aberrant expression of genes regulating apoptosis/survival seems to be essential in the stepwise development of human multiple myeloma (MM). In this paper we have compared the expression of bcl-2 family pro- and anti-apoptotic genes in MM cell lines, primary MM cells and normal plasma cells. The Bcl-2, Mcl-1, Bcl-xL/S...

journal_title：European journal of haematology

authors： Spets H,Strömberg T,Georgii-Hemming P,Siljason J,Nilsson K,Jernberg-Wiklund H

更新日期：2002-08-01 00:00:00

abstract：:It has been reported that in vitro prednisolone (PDN) resistance provides a prognostic value in childhood acute lymphoblastic leukaemia (ALL). This study aimed at investigating the biological and clinical significance of in vitro PDN resistance in adult ALL. Blast cells from 30 patients were exposed to PDN (0.1 microM...

journal_title：European journal of haematology

authors： Tosi P,Visani G,Ottaviani E,Manfroi S,Tura S

更新日期：1996-08-01 00:00:00

abstract：:We are reporting here the results of differential gene expression experiments comparing two siblings, a 21-yr-old male and a 19-yr-old female, with the same alpha-thalassemia genotype (-alpha(3.7)/(--SEA)) and quite different levels of Hb H in the peripheral blood (18.7 and 5%, respectively). By using mRNA differentia...

journal_title：European journal of haematology

authors： Wenning MR,Mello MP,Andrade TG,Lanaro C,Albuquerque DM,Saad ST,Costa FF,Sonati MF

更新日期：2009-11-01 00:00:00

abstract：:Few risk factors have been established for the plasma cell disorder multiple myeloma, but some of these like African American ethnicity and a family history of B-cell lymphoproliferative diseases suggest a genetic component for the disease. Genetic variation represents the genetic basis of variability in a population....

journal_title：European journal of haematology

authors： Vangsted A,Klausen TW,Vogel U

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:More than 90% of children with sickle cell anemia (SCA) lose splenic function by the age of 2 yrs. Splenic function may improve with hydroxyurea, but previous studies are conflicting. We prospectively evaluated the effect of hydroxyurea on splenic filtrative function. METHODS:Children with SCA enrolled in t...

journal_title：European journal of haematology

authors： Nottage KA,Ware RE,Winter B,Smeltzer M,Wang WC,Hankins JS,Dertinger SD,Shulkin B,Aygun B

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Wnt signaling induces a plethora of intracellular responses that dictate normal or abnormal cellular behavior. Abnormal WNT signaling has been related to the development of leukemogenic processes. In this regard, it is important to know the expression profile of WNT receptors in normal and malignant cells, i...

journal_title：European journal of haematology

authors： Alvarez-Zavala M,Riveros-Magaña AR,García-Castro B,Barrera-Chairez E,Rubio-Jurado B,Garcés-Ruíz OM,Ramos-Solano M,Aguilar-Lemarroy A,Jave-Suarez LF

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Fluconazole or posaconazole is a standard of care in antifungal prophylaxis for patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). However, many patients need to interrupt standard prophylaxis due to intolerability, drug-drug interactions, or toxicity. Micafungin has come to promin...

journal_title：European journal of haematology

authors： Rothe A,Claßen A,Carney J,Hallek M,Mellinghoff SC,Scheid C,Holtick U,von Bergwelt-Baildon M

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Recent studies have indicated that patients who receive stem cell transplantation (SCT) and rituximab demonstrate an increased risk of developing hypogammaglobulinemia. Such hypogammaglobulinemia has been found to be due to delayed recovery of memory B cells with an abnormal cell marker expression and impair...

journal_title：European journal of haematology

authors： Nishio M,Endo T,Fujimoto K,Yamamoto S,Obara M,Yamaguchi K,Takeda Y,Goto H,Kasahara I,Sato N,Koike T

更新日期：2009-02-01 00:00:00

abstract：:In whole blood from splenectomized subjects (n = 8) in a steady state an increased number of reticulocytes was observed (14.0 +/- 7.8% versus 3.6 +/- 2.4% controls: p less than 0.05). Cell fractionation on density showed that reticulocytes, as in normals, are more or less confined to the least dense fraction; cell fra...

journal_title：European journal of haematology

authors： De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

更新日期：1988-07-01 00:00:00

abstract：:To determine if mutations of the Wilms' tumor predisposing gene (WT1) are associated with haematological malignancies, we have investigated 65 cases of acute leukaemia, including 39 patients in blast crisis of chronic myeloid leukaemia (CML), by amplification of WT1 exons 7, 8 and 9 followed by single-strand conformat...

journal_title：European journal of haematology

authors： Carapeti M,Goldman JM,Cross NC

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:The single nucleotide polymorphism SNP309 with a change from T to G in the promoter region of the MDM2 gene is shown to increase the MDM2 protein levels and attenuate the p53 levels and associates with disease progression in several tumors. OBJECTIVE:In this study, the role of the polymorphism was investiga...

journal_title：European journal of haematology

authors： Willander K,Ungerbäck J,Karlsson K,Fredrikson M,Söderkvist P,Linderholm M

更新日期：2010-09-01 00:00:00

abstract：:Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the...

journal_title：European journal of haematology

authors： Kamezaki K,Shimoda K,Numata A,Aoki K,Kato K,Takase K,Nakajima H,Ihara K,Haro T,Ishikawa F,Imamura R,Miyamoto T,Nagafuji K,Gondo H,Hara T,Harada M

更新日期：2003-12-01 00:00:00

abstract：:This review summarizes present knowledge on porcine platelets in vitro and recent studies on in vivo activation of platelets in the pig. There are certain differences compared to human platelets: Platelet aggregation and secretion cannot be achieved by epinephrine, and the arachidonate pathway seems poorly developed i...

journal_title：European journal of haematology

authors： Søfteland E,Framstad T,Thorsen T,Holmsen H

更新日期：1992-10-01 00:00:00

abstract：:We describe a case of acute promyelocytic leukemia in a 61-yr-old woman with a cryptic insertion of RARA gene into PML gene. Using a combination of cytogenetic and molecular methods, we confirmed the insertion and presence of the PML-RARA transcript and lack of the reciprocal RARA-PML transcript. Although such cryptic...

journal_title：European journal of haematology

authors： Fan H,Ortega V,Fanasch HM,Wang Y,Holder KN,Higgins RA,Mendiola C,Mohamed G,Vadlamudi K,Velagaleti G

更新日期：2014-10-01 00:00:00

abstract：:In acute myeloid leukemia (AML) mouse models, the RUNX1-RUNX1T1 fusion protein has failed to produce leukemia by itself, but alternative splicing of exon 9a of the RUNX1-RUNX1T1 fusion transcript (FT) has recently been shown to enhance the leukemogenic potential. We have analyzed 138 diagnosis and follow-up samples fr...

journal_title：European journal of haematology

authors： Ommen HB,Ostergaard M,Yan M,Braendstrup K,Zhang DE,Hokland P

更新日期：2010-02-01 00:00:00

abstract：:Cytosine arabinoside (ara-C) and etoposide are often used in combination in the treatment of acute myelocytic leukemia (AML). The intracellular phosphorylation of ara-C to its 5'-triphosphate (ara-CTP) is a prerequisite for its cytotoxic effects. It has been shown in vitro that etoposide can impair the formation of ar...

journal_title：European journal of haematology

authors： Liliemark J,Knochenhauer E,Gruber A,Pettersson B,Björkholm M,Peterson C

更新日期：1993-01-01 00:00:00

abstract：:Von Willebrand disease (VWD) is the most common genetic bleeding disorder. VWD is caused by a deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and binds and stabilises coagulation factor VIII (FVIII) in the blood. Pro...

journal_title：European journal of haematology

authors： Miesbach W,Berntorp E

更新日期：2017-02-01 00:00:00

abstract：:An unusual case having IgM monoclonal gammopathy with clinical and pathologic features of multiple myeloma (MM) in association with neutrophilia and nephrotic syndrome is reported. The patient showed lytic bone lesions, decreased IgG and IgA levels, Bence-Jones proteinuria, nephrotic proteinuria with edema, and histol...

journal_title：European journal of haematology

authors： Gnerre P,Ottonello L,Montecucco F,Boero M,Dallegri F

更新日期：2007-07-01 00:00:00

abstract：UNLABELLED:Protein C (PC) deficiency is an autosomal dominant inherited disorder associated with spontaneous and recurrent thrombotic events. Factor V Leiden (FVL) increases the risk of thrombosis in PC-deficient type I families. We have investigated the relationship between PC deficiency genotype and clinical phenotyp...

journal_title：European journal of haematology

authors： Cafolla A,D'Andrea G,Baldacci E,Margaglione M,Mazzucconi MG,Foà R

更新日期：2012-04-01 00:00:00

abstract：:Our aim was to assess liver iron content, in thalassaemic patients, by using three different MR protocols and compare their data. Ninety-four thalassaemic patients (44 M and 50 F, mean age 25.82 +/- 8.3 yrs), were enrolled in the study. In each patient, three measurements of the liver iron content were performed, with...

journal_title：European journal of haematology

authors： Christoforidis A,Perifanis V,Spanos G,Vlachaki E,Economou M,Tsatra I,Athanassiou-Metaxa M

更新日期：2009-05-01 00:00:00

abstract：:The present trial was designed to test the effects of G-CSF on the duration of the second phase of induction chemotherapy in children with newly diagnosed acute lymphoblastic leukemia (ALL). A total of 32 patients were assigned randomly to a group that received (14 patients; group A) or a group that did not receive (1...

journal_title：European journal of haematology

authors： Dibenedetto SP,Ragusa R,Ippolito AM,Lo Nigro L,Di Cataldo A,D'Amico S,Miraglia V

更新日期：1995-08-01 00:00:00

abstract：:Relapse represents the most significant cause of failure of allogeneic hematopoietic stem cell transplantation (HSCT) for FLT3-ITD-positive acute myeloid leukemia (AML), and available therapies are largely unsatisfactory. In this study, we retrospectively collected data on the off-label use of the tyrosine kinase inhi...

journal_title：European journal of haematology

authors： De Freitas T,Marktel S,Piemontese S,Carrabba MG,Tresoldi C,Messina C,Lupo Stanghellini MT,Assanelli A,Corti C,Bernardi M,Peccatori J,Vago L,Ciceri F

更新日期：2016-06-01 00:00:00

abstract：:We serially determined serum erythropoietin (Epo) and the reticulocyte count in patients with various types of leukemia during chemotherapy. Serum Epo increased soon after the initiation of chemotherapy and decreased after the termination of therapy irrespective of the types of leukemia or treatment regimen. However, ...

journal_title：European journal of haematology

authors： Sawabe Y,Kikuno K,Iseki T,Lida S,Tabata Y,Yonemitsu H

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Most results on the treatment of chronic myeloid leukaemia (CML) with imatinib were obtained from clinical trials that may differ from the routine practice. We report the results of treatment of consecutive patients with CML at ten major centres during 2000-2008. PATIENTS AND METHODS:Data reporting was retr...

journal_title：European journal of haematology

authors： Faber E,Mužík J,Koza V,Demečková E,Voglová J,Demitrovičová L,Chudej J,Markuljak I,Cmunt E,Kozák T,Tóthová E,Jarošová M,Dušek L,Indrák K

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:On the basis of two population-based registries, our study aims to calculate the real-world cost-effectiveness of rituximab maintenance compared with observation in relapsed or refractory follicular lymphoma patients who responded to second-line chemotherapy. METHODS:Data were obtained from the EORTC20981 t...

journal_title：European journal of haematology

authors： Blommestein HM,Issa DE,Pompen M,Ten Hoor G,Hogendoorn M,Joosten P,Zweegman S,Huijgens PC,Uyl-de Groot CA

更新日期：2014-01-01 00:00:00

abstract：:As a component of the MRN complex (which is a heterotrimeric protein complex consisting of MRE11, RAD50 and NBS1), NBS1 plays an important role in cellular response to DNA damage and the maintenance of chromosomal integrity. Leukemia is common in NBS1 germ line-mutated patients. The NBS1 E185Q polymorphism (8360G>C, r...

journal_title：European journal of haematology

authors： Jiang L,Liang J,Jiang M,Yu X,Zheng J,Liu H,Wu D,Zhou Y

更新日期：2011-03-01 00:00:00