Bridging antifungal prophylaxis with 50 mg or 100 mg micafungin in allogeneic stem cell transplantation: A retrospective analysis.

abstract：:There are established guidelines for treatment and monitoring of chronic myeloid leukemia (CML) but little is known about routine care. Data on ICD-10 codes as well as prescribed medications were available for 10.5 million patients in the statutory health insurance system in Bavaria for the years 2010 to 2016. Also, d...

journal_title：European journal of haematology

authors： Lauseker M,Gerlach R,Worseg W,Haferlach T,Tauscher M,Hasford J,Hoffmann VS

更新日期：2019-10-01 00:00:00

abstract：:Myeloproliferative neoplasms associated with FIP1L1-PDGFR rearrangements represent a rare subset of myeloid and lymphoid malignancies, characterised by the presence of eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 genes. The fusion product of such genes is a tyrosine kinase oncoprotein sensitive to imatini...

journal_title：European journal of haematology

authors： Barraco D,Carobolante F,Candoni A,Simeone E,Piccaluga P,Tabanelli V,Fanin R

更新日期：2014-06-01 00:00:00

abstract：:Immune reconstitution may be delayed after CD34-selected compared with unmanipulated autologous peripheral blood stem cell transplantation (PBSCT), resulting in a theoretically increased risk of infections. In a case-control matched study we compared the incidence of infection in 25 recipients of CD34-selected PBSC (C...

journal_title：European journal of haematology

authors： Frère P,Pereira M,Fillet G,Beguin Y

更新日期：2006-02-01 00:00:00

abstract：:The use of rituximab is increasing and regular administration over 2 to 3 h requires considerable healthcare resources and is inconvenient for patients. There is interest in reducing rituximab administration times and although infusion of rituximab over 90 min is safe, there is limited data on the safety of 60 min inf...

journal_title：European journal of haematology

authors： Tuthill M,Crook T,Corbet T,King J,Webb A

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Both carcinoma of the prostate and non-Hodgkin's lymphoma are common in elderly patients. Measurement of serum prostate-specific antigen (PSA) is a frequently used tool to diagnose and monitor prostate carcinoma and is generally specific for diseases of the prostate. CASE:We describe a 68-yr-old patient with...

journal_title：European journal of haematology

authors： Oosterheert JJ,Budel LM,Vos P,Wittebol S

更新日期：2007-08-01 00:00:00

abstract：:The introduction of novel immunomodulatory drugs (IMiDs) has dramatically improved the survival of patients with multiple myeloma (MM). While it has been shown that patients with specific cytogenetic subtypes, namely t(4;14), have the best outcomes when treated with bortezomib-based regimens, the relationship between ...

journal_title：European journal of haematology

authors： Greenberg AJ,Walters DK,Kumar SK,Rajkumar SV,Jelinek DF

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:MicroRNAs engaged in angiogenesis and hematopoiesis can influence hematopoietic stem cells (HSCs) homing after transplantation by targeting bone marrow niche microenvironment. This study aimed to examine the kinetics of miRNA-15a, miRNA-16, miRNA-126, miRNA-146a, and miRNA-223 in autologous HSC transplantatio...

journal_title：European journal of haematology

authors： Nowicki M,Szemraj J,Wierzbowska A,Misiewicz M,Małachowski R,Pluta A,Grzybowska-Izydorczyk O,Robak T,Szmigielska-Kapłon A

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the kinetics of molecular response in chronic myeloid leukemia (CML) patients treated with imatinib and to compare between the fluorescent in situ hybridization (FISH), multiplex and real-time quantitative RT-PCR (RQ-PCR) methods with this respect. METHODS:Molecula...

journal_title：European journal of haematology

authors： Raanani P,Ben-Bassat I,Gan S,Trakhtenbrot L,Mark Z,Ashur-Fabian O,Itskovich S,Brok-Simoni F,Rechavi G,Amariglio N,Nagler A

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:From 1954 to 1987, flour in Denmark was fortified with 30 mg carbonyl iron per kg. This mandatory fortification was abolished in 1987. The aim of this study was to compare iron status in Danish men before and after abolition of iron fortification. METHODS:Iron status (serum ferritin, haemoglo...

journal_title：European journal of haematology

authors： Milman N,Byg KE,Ovesen L,Kirchhoff M,Jürgensen KS

更新日期：2002-06-01 00:00:00

abstract：:For patients with severe and refractory autoimmune diseases, high-dose chemotherapy and autologous hematopoietic stem cell transplantation has been established as a considerable therapeutic option in recent years. In this retrospective single-center analysis, we assessed the feasibility and efficacy of peripheral bloo...

journal_title：European journal of haematology

authors： Blank N,Lisenko K,Pavel P,Bruckner T,Ho AD,Wuchter P

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:Current prognostic models for myelodysplastic syndrome (MDS) do not consider the prognostic value of a bone marrow blast level that is <5%. Exploring the prognostic value of the International Prognostic Scoring System (IPSS) and a marrow blast level that is <5% may lead to better risk-adapted therapeutic str...

journal_title：European journal of haematology

authors： Wang H,Wang XQ,Xu XP,Lin GW

更新日期：2009-12-01 00:00:00

abstract：:Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm, characterized by persistent monocytosis. Due to the lack of unique surface markers expressed by neoplastic monocytes and the frequent CD34-negative blast immunophenotype, the diagnostic value of flow cytometric immunophenotyping (...

journal_title：European journal of haematology

authors： Shen Q,Ouyang J,Tang G,Jabbour EJ,Garcia-Manero G,Routbort M,Konoplev S,Bueso-Ramos C,Medeiros LJ,Jorgensen JL,Wang SA

更新日期：2015-08-01 00:00:00

abstract：:A 1-yr-old Japanese male infant developed hepatitis-associated aplastic anemia (AA), and anti-thymocyte globulin (ATG) plus cyclosporine A (CsA) was administered without any appreciable effects. Laboratory examination of the patient's serum obtained before therapy revealed various autoantibodies, such as PA-IgG, anti-...

journal_title：European journal of haematology

authors： Takamatsu H,Yagasaki H,Takahashi Y,Hama A,Saikawa Y,Yachie A,Koizumi S,Kojima S,Nakao S

更新日期：2011-06-01 00:00:00

abstract：:Soluble tumour necrosis factor receptors (sTNF-Rs) play a role as modulators of the biological function of tumour necrosis factor-alpha (TNF-alpha) in an agonist/antagonist pattern. In various pathologic states the production and release of sTNF-Rs may mediate host response and determine the course and outcome of dise...

journal_title：European journal of haematology

authors： Diez-Ruiz A,Tilz GP,Zangerle R,Baier-Bitterlich G,Wachter H,Fuchs D

更新日期：1995-01-01 00:00:00

abstract：:MYH9 disorders are autosomal dominant macrothrombocytopenias with leukocyte inclusion bodies. Single point mutations in the protein-coding sequence of the MYH9 gene are the most common cause. So far no large gene deletion/insertion and splicing defects have been reported. Conventional DNA sequencing of each MYH9-codin...

journal_title：European journal of haematology

authors： Kunishima S,Matsushita T,Hamaguchi M,Saito H

更新日期：2008-06-01 00:00:00

abstract：:This study is designed to investigate whether apoptosis occurs in vivo in pediatric patients with acute leukemia during induction therapy. When patients with common acute lymphoblastic leukemia (cALL) and acute myeloblastic leukemia (AML) were treated with prednisolone (60 mg/m2/day, p.o. or i.v.) and etoposide (150 m...

journal_title：European journal of haematology

authors： Matsubara K,Kubota M,Adachi S,Kuwakado K,Hirota H,Wakazono Y,Akiyama Y,Mikawa H

更新日期：1994-01-01 00:00:00

abstract：:The present trial was designed to test the effects of G-CSF on the duration of the second phase of induction chemotherapy in children with newly diagnosed acute lymphoblastic leukemia (ALL). A total of 32 patients were assigned randomly to a group that received (14 patients; group A) or a group that did not receive (1...

journal_title：European journal of haematology

authors： Dibenedetto SP,Ragusa R,Ippolito AM,Lo Nigro L,Di Cataldo A,D'Amico S,Miraglia V

更新日期：1995-08-01 00:00:00

abstract：:Dyskeratosis congenita (DC) is a rare familial hematologic disorder that has various modes of inheritance. We have studied 2 siblings with DC. 1 sibling had thrombocytopenia, which responded to therapy with nandrolone decanoate and oxymetholone. Platelets were abnormally small, which indicates that a qualitatively abn...

journal_title：European journal of haematology

authors： Juneja HS,Elder FF,Gardner FH

更新日期：1987-10-01 00:00:00

abstract：:By recent advanced techniques, blood platelets have proved to be varied in size and metabolism in various hematologic disorders. We examined platelet volume and intraplatelet adenine nucleotides in 36 patients with various hematologic disorders in order to clarify the quantitative platelet abnormalities. Platelet volu...

journal_title：European journal of haematology

authors： Nozaki H,Nagao T,Arimori S

更新日期：1988-01-01 00:00:00

abstract：:Immune thrombocytopenic purpura (ITP) is an autoimmune disorder, and high-dose dexamethasome (HD-DXM) has been used as a first-line therapy for patients with ITP. However, little is known about the role of dendritic cells (DCs) and CD4(+)Foxp3(+) regulatory T (Treg) cells in the pathogenesis of chronic ITP and the eff...

journal_title：European journal of haematology

authors： Ling Y,Cao X,Yu Z,Ruan C

更新日期：2007-10-01 00:00:00

abstract：:Emicizumab, a bispecific humanised monoclonal antibody restoring to some extent the function of activated FVIII deficient in haemophilia A, represents a major therapeutic advance in the management of haemophilia A patients. No dosage adjustment is required, which leads to a major change for patients used to regular bi...

journal_title：European journal of haematology

authors： Nougier C,Jeanpierre E,Ternisien C,Proulle V,Hezard N,Pouplard C,Lasne D,With contributions from the Working Group on Biology of Haemorrhagic Disorders (BIMHO, Under the Aegis of GFHT).

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:This review describes the safety of deferoxamine (DFO), deferiprone (DFP), deferasirox (DFX) and combined therapy in young patients less than 25 yr of age with haemoglobinopathies. METHODS:Searches in electronic literature databases were performed. Studies reporting adverse events associated with iron chela...

journal_title：European journal of haematology

authors： Botzenhardt S,Li N,Chan EW,Sing CW,Wong IC,Neubert A

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:Pulmonary hypertension (PH) is commonly reported in Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs) including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF). PH may be diagnosed directly by right heart catheterization (RHC) or estimated by transthoracic ec...

journal_title：European journal of haematology

authors： Ferrari A,Scandura J,Masciulli A,Krichevsky S,Gavazzi A,Barbui T

更新日期：2021-02-01 00:00:00

abstract：:We demonstrate the in vivo effects of bacterially synthesized, N-methionine-free recombinant human granulocyte-macrophage colony stimulating factor (rh GM-CSF) using a crab-eating monkey model. Monkeys were treated with cyclophosphamide (60 mg/kg) and administered with rh GM-CSF (30 micrograms/kg/d) subcutaneously (s....

journal_title：European journal of haematology

authors： Akashi K,Taniguchi S,Teshima T,Shibuya T,Okamura T,Harada M,Niho Y

更新日期：1990-02-01 00:00:00

abstract：:The purpose of this study was to analyse the influence of the hospital size, measured as the number of annual patient enrolments in the Finnish Leukaemia Group trials in the period 1979-85, on response rate and survival after conventional chemotherapy for multiple myeloma. The 432 myeloma patients for this study were ...

journal_title：European journal of haematology

authors： Oivanen T,Kellokumpu-Lehtinen P,Koivisto AM,Koivunen E

更新日期：1999-10-01 00:00:00

abstract：:The Hermansky-Pudlak syndrome (HPS) is a rare genetically heterogeneous autosomal recessive disorder, characterized by tyrosinase-positive oculocutaneous albinism, platelet dysfunction and lysosomal ceroid lipofuscin storage. This is caused by defects in lysosome-related organelles. In humans eight different types of ...

journal_title：European journal of haematology

authors： Korswagen LA,Huizing M,Simsek S,Janssen JJ,Zweegman S

更新日期：2008-04-01 00:00:00

abstract：:Involvement of the central nervous system (CNS) in multiple myeloma (MM) is very uncommon; it has been observed in approximately 1% of the MM patients. This review summarizes the clinical and laboratory characteristics and treatment modalities of 109 patients with CNS myelomatosis (CNS MM) reported in the literature. ...

journal_title：European journal of haematology

authors： Nieuwenhuizen L,Biesma DH

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Detection of iron deficiency during pregnancy with hemoglobin (Hb) and serum measurements is insignificant as the measurements may be affected by e.g. hemodilution or accelerated erythropoiesis. This study tests whether cell indices will give a more reliable measure of iron deficiency in pregnant women at te...

journal_title：European journal of haematology

authors： Ervasti M,Kotisaari S,Heinonen S,Punnonen K

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Although there are two major scoring systems for the clinical diagnosis of disseminated intravascular coagulation (DIC), the validity of these systems for leukemia-associated DIC remains to be confirmed. METHODS:By analyzing 125 newly diagnosed acute leukemia patients, we investigated clinical and laborator...

journal_title：European journal of haematology

authors： Yanada M,Matsushita T,Suzuki M,Kiyoi H,Yamamoto K,Kinoshita T,Kojima T,Saito H,Naoe T

更新日期：2006-10-01 00:00:00

abstract：:Steroid-refractory graft-versus-host disease (GvHD) is a complication following an allogeneic stem cell transplantation with limited therapeutic options. Studies have shown a response in up to 80% of patients with this condition after treatment with the CD25 monoclonal antibody, basiliximab. Despite the good responses...

journal_title：European journal of haematology

authors： Chakupurakal G,García-Márquez MA,Shimabukuro-Vornhagen A,Theurich S,Holtick U,Hallek M,Scheid C,von Bergwelt-Baildon M

更新日期：2016-08-01 00:00:00