Bone marrow blasts level predicts prognosis in patients with refractory cytopenia with multilineage dysplasia.

abstract：:The candidate tumour suppressor gene MMAC1/PTEN located at chromosome 10q23.3 has been reported to be frequently mutated in a number of solid tumours. Less is known about its status in leukaemia. In the present study we first analysed 13 leukaemia cell lines for mutations and homozygous deletions in MMAC1/PTEN using P...

journal_title：European journal of haematology

authors： Aggerholm A,Grønbaek K,Guldberg P,Hokland P

更新日期：2000-08-01 00:00:00

abstract：:We report the first case of primary sclerosing cholangitis (PSC) complicated with plasma cell dyscrasia (PCD) in which liver transplant resulted in unexpected therapeutic benefit of PCD. A 61-year-old man with 12 yr history of PSC presented with a monoclonal gammopathy of undetermined significance (MGUS) with an IgG l...

journal_title：European journal of haematology

authors： Fontana V,Ahn YS,Horstman LH,Tzakis AG,O'Brien CB

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVES:To investigate whether the glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab (GA101) combined with the selective MDM2 antagonist idasanutlin (RG7388) offers superior efficacy to monotherapy in treating B-lymphoid malignancies in preclinical models. METHODS:The combined effect of obinutuzuma...

journal_title：European journal of haematology

authors： Herting F,Herter S,Friess T,Muth G,Bacac M,Sulcova J,Umana P,Dangl M,Klein C

更新日期：2016-11-01 00:00:00

abstract：:Using a multiparameter flow cytometry assay enumerating cells positive for CD13, CD14 and CD66 antigens, we determined the asynchronous CD14/CD66 co-expression in unselected bone marrow and peripheral blood samples with suspected malignant blood disorders. CD14/CD66 co-expression > or = 5% were found in 131/691 bone m...

journal_title：European journal of haematology

authors： Hansen I,Meyer K,Hokland P

更新日期：1998-11-01 00:00:00

abstract：:Emicizumab, a bispecific humanised monoclonal antibody restoring to some extent the function of activated FVIII deficient in haemophilia A, represents a major therapeutic advance in the management of haemophilia A patients. No dosage adjustment is required, which leads to a major change for patients used to regular bi...

journal_title：European journal of haematology

authors： Nougier C,Jeanpierre E,Ternisien C,Proulle V,Hezard N,Pouplard C,Lasne D,With contributions from the Working Group on Biology of Haemorrhagic Disorders (BIMHO, Under the Aegis of GFHT).

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:The exact fate of polymorphonuclear neutrophilic granulocytes (PMN; neutrophils) after their mobilization from the bone marrow is not known. It is believed that they, after a relatively short lifespan (1-3 d), become apoptotic and phagocytosed by macrophages. We have recently shown that transfused neutrophils...

journal_title：European journal of haematology

authors： Knudsen E,Benestad HB,Seierstad T,Iversen PO

更新日期：2004-08-01 00:00:00

abstract：:This study describes a retrospective analysis on the transplant outcome of 56 consecutive patients with myelodysplastic syndrome (MDS) according to their response to hypomethylating agents (HMA). While 2-yr disease-free survival (DFS) of patients who transformed to acute myeloid leukemia (n = 12) was 25%, that of the ...

journal_title：European journal of haematology

authors： Yahng SA,Yoon JH,Shin SH,Lee SE,Cho BS,Lee DG,Eom KS,Lee S,Min CK,Kim HJ,Cho SG,Kim DW,Lee JW,Min WS,Kim TG,Park CW,Kim YJ

更新日期：2013-02-01 00:00:00

abstract：:Upshaw-Schulman syndrome (USS) is due to severe congenital deficiency of von Willebrand factor (VWF)-cleaving protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 domains, nr 13) activity resulting in the presence of unusually large forms of VWF in the circulation, causing intravascular plat...

journal_title：European journal of haematology

authors： Rank CU,Kremer Hovinga J,Taleghani MM,Lämmle B,Gøtze JP,Nielsen OJ

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To retrospectively identify characteristics and risk factors of viral encephalitis (VE) in patients who underwent a haplo-identical hematopoietic stem cell transplant (HSCT). METHODS:A nested case-control study was designed. Cases with VE and controls were identified from a cohort composed of 1274 patients w...

journal_title：European journal of haematology

authors： Zhang XH,Zhang JM,Han W,Chen H,Chen YH,Wang FR,Wang JZ,Zhang YY,Mo XD,Chen Y,Wang Y,Chang YJ,Xu LP,Liu KY,Huang XJ

更新日期：2017-05-01 00:00:00

abstract：:A transgenic SCID (TG-SCID) mouse expressing the human cytokines interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) has been generated with the aim of making a model system allowing the in vivo proliferation of human hematopoietic cells. Using TG-SCID mice expressing high levels (30-35 ...

journal_title：European journal of haematology

authors： Kim DK,Kojima M,Fukushima T,Miyasaka M,Nakauchi H

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:To determine the financial and psycho-social impact of participation in clinical trials of patients with BCR/ABL-negative myeloproliferative neoplasms (MPN). METHODS:An international, observational cross-sectional study was performed in 143 consecutive MPN patients (51% myelofibrosis, 36% polycythemia vera, ...

journal_title：European journal of haematology

authors： Goel S,Paoli C,Iurlo A,Pereira A,Efficace F,Barbui T,Tefferi A,Vannucchi AM,Cervantes F

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to determine whether angelicin is able to increase the expression of gamma-globin genes in human erythroid cells. Angelicin is structurally related to psoralens, a well-known chemical class of photosensitizers used for their antiproliferative activity in treatment of different skin dis...

journal_title：European journal of haematology

authors： Lampronti I,Bianchi N,Borgatti M,Fibach E,Prus E,Gambari R

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The occurrence of a thrombotic event in congenital bleeding disorders has drawn considerable attention in recent years. Both patients with hemophilia and patients with von Willebrand disease and even those with rare coagulation disorders have been shown to present occasional thrombotic events. Little is know...

journal_title：European journal of haematology

authors： Girolami A,Berti de Marinis G,Bertozzi I,Peroni E,Tasinato V,Lombardi AM

更新日期：2013-08-01 00:00:00

abstract：:The management of anticoagulant therapy (OAT) in patients with factor VII (FVII) deficiency is a very challenging clinical issue, as warfarin further reduces FVII levels, thus potentially increasing bleeding risk. On the other hand, the International Normalized Ratio test is misleading in such patients, as they do not...

journal_title：European journal of haematology

authors： Arletti L,Coluccio V,Romagnoli E,Luppi M,Marietta M

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:To compare the gene expression pattern in children and adults with acute lymphoblastic leukaemia (ALL) in order to improve our understanding of the difference in disease biology and prognosis. METHODS:The gene expression profiles in diagnostic samples from 29 children and 15 adults with ALL were analysed us...

journal_title：European journal of haematology

authors： Kuchinskaya E,Heyman M,Grandér D,Linderholm M,Söderhäll S,Zaritskey A,Nordgren A,Porwit-Macdonald A,Zueva E,Pawitan Y,Corcoran M,Nordenskjöld M,Blennow E

更新日期：2005-06-01 00:00:00

abstract：:High mobility group box 1 protein (HMGB1), originally described as a non-histone, DNA binding protein, was recently identified as a late mediator of inflammation via its extracellular release from activated macrophages/monocytes. In the present study, we report that intracellular HMGB1 synergizes with a macrophage/mon...

journal_title：European journal of haematology

authors： Mouri F,Tsukada J,Mizobe T,Higashi T,Yoshida Y,Minami Y,Izumi H,Kominato Y,Kohno K,Tanaka Y

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Clonal dominance is characteristic of patients with post-polycythemia vera myelofibrosis (post-PV MF), whereas patients in chronic phase usually display polyclonal hematopoiesis. The aim of this work was to study the mutational burden of JAK2V617F at the progenitor level in patients with PV and correlate it ...

journal_title：European journal of haematology

authors： Angona A,Alvarez-Larrán A,Bellosillo B,Martínez-Avilés L,Camacho L,Fernández-Rodríguez C,Pairet S,Longarón R,Ancochea Á,Senín A,Florensa L,Besses C

更新日期：2015-03-01 00:00:00

abstract：:We are reporting here the results of differential gene expression experiments comparing two siblings, a 21-yr-old male and a 19-yr-old female, with the same alpha-thalassemia genotype (-alpha(3.7)/(--SEA)) and quite different levels of Hb H in the peripheral blood (18.7 and 5%, respectively). By using mRNA differentia...

journal_title：European journal of haematology

authors： Wenning MR,Mello MP,Andrade TG,Lanaro C,Albuquerque DM,Saad ST,Costa FF,Sonati MF

更新日期：2009-11-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) encodes a major enzyme in folate metabolism. It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL). Most studies on relation of MTHFR polymorphisms to ALL susceptibility have been in pediatric populat...

journal_title：European journal of haematology

authors： Lv L,Wu C,Sun H,Zhu S,Yang Y,Chen X,Fu H,Bao L

更新日期：2010-06-01 00:00:00

abstract：:We studied the chromosomes in the bone marrow of 4 patients who had both diabetes insipidus (DI) and acute non-lymphocytic leukaemia. Clinical findings suggested that, in each case, myelodysplastic syndrome had preceded the onset of acute leukaemia. Two other such patients described in the literature had had a banded ...

journal_title：European journal of haematology

authors： de la Chapelle A,Lahtinen R

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVES:Disseminated adenovirus (AdV) infections following allogeneic stem cell transplantation (allo-SCT) are increasingly recognised, particularly in children. This study evaluated the clinical relevance of disseminated AdV infections in adult allo-SCT recipients, after different conditioning regimens. METHODS:In...

journal_title：European journal of haematology

authors： Kalpoe JS,van der Heiden PL,Barge RM,Houtzager S,Lankester AC,van Tol MJ,Kroes AC

更新日期：2007-04-01 00:00:00

abstract：:Treatment with recombinant erythropoietin (EPO) can alleviate anaemia in patients with myelodysplastic syndromes (MDS). The present study, based on a long-term follow-up of 68 MDS patients (26RA, 16 RAS, 26 RAEB) treated with EPO alone, pinpoints pre-treatment variables associated with response induction, response dur...

journal_title：European journal of haematology

authors： Wallvik J,Stenke L,Bernell P,Nordahl G,Hippe E,Hast R

更新日期：2002-03-01 00:00:00

abstract：:Acute tumour lysis syndrome (ATLS) is a well recognised complication of treatment of a variety of malignant disorders. It commonly occurs in patients with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL) with the administration of combined cytotoxic chemotherapy. It is rarely reported after single-...

journal_title：European journal of haematology

authors： Duzova A,Cetin M,Gümrük F,Yetgin S

更新日期：2001-06-01 00:00:00

abstract：:A flow cytometric assay for measurements of leukocyte CD11b expression in whole blood has been developed and evaluated. The method is based on triggering of the flow cytometer by a fluorescent pan leukocyte marker, RPE-CD45. This enabled flow cytometric analysis in whole blood, and avoidance of in vitro artefacts rela...

journal_title：European journal of haematology

authors： Li N,Halldén G,Hjemdahl P

更新日期：2000-07-01 00:00:00

abstract：:This study shows that the ingestion of ethanol provokes alterations in iron metabolism which may lead to iron overload. Impaired release of reticuloendothelial iron was shown by a decrease of the maximum red blood cell utilization when radioactive iron was supplied as colloidal iron. An impairment in the erythropoieti...

journal_title：European journal of haematology

authors： Sánchez J,Casas M,Rama R

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVES:Detection of iron deficiency during pregnancy with hemoglobin (Hb) and serum measurements is insignificant as the measurements may be affected by e.g. hemodilution or accelerated erythropoiesis. This study tests whether cell indices will give a more reliable measure of iron deficiency in pregnant women at te...

journal_title：European journal of haematology

authors： Ervasti M,Kotisaari S,Heinonen S,Punnonen K

更新日期：2007-12-01 00:00:00

abstract：:Patients with essential thrombocythemia (ET) often suffer from neurological symptoms (NS) not ever resulting from previous thrombotic cerebral events (TCE). We reported NS occurred in 282 patients, in order to identify the factors influencing ET-related NS in the absence of TCE, and the response to therapy. Overall, 1...

journal_title：European journal of haematology

authors： Aroldi A,Cecchetti C,Colombo A,Cattaneo L,Pioltelli PE,Pogliani EM,Elli EM

更新日期：2016-06-01 00:00:00

abstract：:Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum...

journal_title：European journal of haematology

authors： Schaer DJ,Schleiffenbaum B,Kurrer M,Imhof A,Bächli E,Fehr J,Moller HJ,Moestrup SK,Schaffner A

更新日期：2005-01-01 00:00:00

abstract：:The effect of human recombinant interferon alpha 2 (IFN alpha 2) on hairy cells obtained from 16 patients was evaluated. All patients promptly responded to induction of remission with 2 X 10(6) U/m2 interferon alpha 2 b, three times a week, sc. In order to achieve a more detailed insight into the mode of action of int...

journal_title：European journal of haematology

authors： Schwarzmeier JD,Schwabe M,Prischl F,Wagner L,Lion T,Micksche M,Köller U

更新日期：1987-11-01 00:00:00

abstract：INTRODUCTION:Chimeric antigen receptor (CAR) T cells targeting B cell maturation antigen (BCMA) have shown impressive results in clinical studies for relapsed/refractory multiple myeloma (RRMM). We performed a systematic literature review to summarize the current body of evidence on the role of anti-BCMA CAR T cells fo...

journal_title：European journal of haematology

authors： Gagelmann N,Ayuk F,Atanackovic D,Kröger N

更新日期：2020-04-01 00:00:00