Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1.

abstract：:We are reporting here the results of differential gene expression experiments comparing two siblings, a 21-yr-old male and a 19-yr-old female, with the same alpha-thalassemia genotype (-alpha(3.7)/(--SEA)) and quite different levels of Hb H in the peripheral blood (18.7 and 5%, respectively). By using mRNA differentia...

journal_title：European journal of haematology

authors： Wenning MR,Mello MP,Andrade TG,Lanaro C,Albuquerque DM,Saad ST,Costa FF,Sonati MF

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:An excessive intramedullar progenitor cell apoptosis, to which elevated expression of tumor necrosis factor-alpha (TNF-alpha) might contribute, is considered the main cause of inefficient hematopoiesis in myelodysplastic syndromes (MDS). Enhanced bone marrow (BM) angiogenesis is regarded as an essential cofa...

journal_title：European journal of haematology

authors： Stifter G,Heiss S,Gastl G,Tzankov A,Stauder R

更新日期：2005-12-01 00:00:00

abstract：:Anaemia of inflammation (AI) is a frequent complication in patients suffering from chronic inflammatory disorders including infections, autoimmune and malignant disease. Cytokine imbalance with a shift towards T-helper (Th)1-type immune response seems to be important in the pathogenesis of this type of anaemia. Interf...

journal_title：European journal of haematology

authors： Weiss G,Schroecksnadel K,Mattle V,Winkler C,Konwalinka G,Fuchs D

更新日期：2004-02-01 00:00:00

abstract：:An unusual case having IgM monoclonal gammopathy with clinical and pathologic features of multiple myeloma (MM) in association with neutrophilia and nephrotic syndrome is reported. The patient showed lytic bone lesions, decreased IgG and IgA levels, Bence-Jones proteinuria, nephrotic proteinuria with edema, and histol...

journal_title：European journal of haematology

authors： Gnerre P,Ottonello L,Montecucco F,Boero M,Dallegri F

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:Pulmonary hypertension (PH) is commonly reported in Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs) including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF). PH may be diagnosed directly by right heart catheterization (RHC) or estimated by transthoracic ec...

journal_title：European journal of haematology

authors： Ferrari A,Scandura J,Masciulli A,Krichevsky S,Gavazzi A,Barbui T

更新日期：2021-02-01 00:00:00

abstract：:Cancer cells are characterized by having chromosomal abnormalities. The number of aberrations and the specific chromosomes affected are likely correlated with tumor progression. In this study, we analyzed the karyotype of 126 plasma cell leukemia (PCL) patients to identify the most frequently occurring imbalances and ...

journal_title：European journal of haematology

authors： Jimenez-Zepeda VH,Neme-Yunes Y,Braggio E

更新日期：2011-07-01 00:00:00

abstract：:In further studying the mechanism of action of IFN-alpha in HCL, we cultured the HCL cell line JOK-1 and the IFN-sensitive Burkitt cell line Daudi with and without IFN-alpha and investigated the changes in density of a number of surface antigens by use of mAb and flow cytometry analyses. During culture with IFN-alpha,...

journal_title：European journal of haematology

authors： Nielsen B,Madsen PS,Jensen AW,Hokland P,Hokland M

更新日期：1992-03-01 00:00:00

abstract：:From a retrospective multivariate study on 107 multiple myeloma (MM) patients, serum beta 2-microglobulin (beta 2M) proved to be the best prognostic discriminator, better than each of the currently used staging systems (Durie and Salmon's [DS], Merlini, Waldenström and Jayakar's [MWJ] and the British Medical Research ...

journal_title：European journal of haematology

authors： Gobbi PG,Bertoloni D,Grignani G,Pieresca C,Rossi A,Rutigliano L,Merlini G,Riccardi A,Ascari E

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVES:As hepcidin-25 is considered as a key regulator of human iron homoeostasis, this study aimed to compare this parameter with conventional biomarkers and diagnostic tools of iron deficiency (ID). METHODS:In total, 233 hospitalised adult patients, who underwent routine blood testing for ID, were included. All ...

journal_title：European journal of haematology

authors： Enko D,Wagner H,Kriegshäuser G,Kimbacher C,Stolba R,Worf E,Halwachs-Baumann G

更新日期：2015-12-01 00:00:00

abstract：:We analyzed the expression of the inhibitor of apoptosis survivin by immunocytochemistry in bone marrow cells from patients with chronic myelomonocytic leukemia (CMML) to evaluate possible abnormalities in comparison with other myelodysplastic (MDS) and myeloproliferative syndromes, and to investigate a possible corre...

journal_title：European journal of haematology

authors： Invernizzi R,Travaglino E,Benatti C,Malcovati L,Della Porta M,Cazzola M,Ascari E

更新日期：2006-06-01 00:00:00

abstract：:Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum...

journal_title：European journal of haematology

authors： Schaer DJ,Schleiffenbaum B,Kurrer M,Imhof A,Bächli E,Fehr J,Moller HJ,Moestrup SK,Schaffner A

更新日期：2005-01-01 00:00:00

abstract：:In whole blood from splenectomized subjects (n = 8) in a steady state an increased number of reticulocytes was observed (14.0 +/- 7.8% versus 3.6 +/- 2.4% controls: p less than 0.05). Cell fractionation on density showed that reticulocytes, as in normals, are more or less confined to the least dense fraction; cell fra...

journal_title：European journal of haematology

authors： De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

更新日期：1988-07-01 00:00:00

abstract：:Forty-one patients with codon 17, A-T mutation of beta-thalassemia, which is commonly found in Thailand, were studied to determine whether it is possible to predict phenotypic severity from genetic factors. The clinical phenotype of homozygotes for codon 17, A-T and compound heterozygotes for codon 17, A-T and beta+-t...

journal_title：European journal of haematology

authors： Laosombat V,Wongchanchailert M,Sattayasevana B,Wiriyasateinkul A,Fucharoen S

更新日期：2001-02-01 00:00:00

abstract：:Plasma cell leukemia (PCL) is a very aggressive and rare form of malignant monoclonal gammopathy characterized by the presence of plasmocytes in peripheral blood. It is classified as primary PCL occuring 'de novo', or as secondary PCL in patients with relapsed/refractory multiple myeloma. Primary PCL is a distinct cli...

journal_title：European journal of haematology

authors： Jelinek T,Kryukov F,Rihova L,Hajek R

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:The primary objective was to assess the effect of central nervous system involvement in acute myeloid leukemia (CNS-AML) on outcomes after allogeneic hematopoietic stem cell transplant (allo-HCT). The secondary objective was to assess the utility of pretransplant cerebrospinal fluid (CSF) assessment in AML. ...

journal_title：European journal of haematology

authors： Prem S,Atenafu EG,Avena J,Bautista R,Law A,Lam W,Michelis FV,Kim DDH,Viswabandya A,Lipton JH,Mattsson J,Kumar R

更新日期：2019-11-01 00:00:00

abstract：:T-cell lymphoma is an aggressive lymphoma that cannot be cured despite aggressive therapy, including autologous stem cell transplantation. Thalidomide is an immunomodulatory drug with numerous properties that has proven effective in relapsed multiple myeloma and, to a lesser extent, in other hematologic diseases. We r...

journal_title：European journal of haematology

authors： Damaj G,Bouabdallah R,Vey N,Bilger K,Mohty M,Gastaut JA

更新日期：2005-02-01 00:00:00

abstract：UNLABELLED:Historically, treatment of invasive fungal infections (IFI) has consisted of amphotericin B. However, new therapeutic agents have recently been introduced. At the same time, the relatively low incidence of IFI and the progress in the diagnostic accuracy of IFI have made routine use of empirical antifungal th...

journal_title：European journal of haematology

authors： Cherif H,Kalin M,Björkholm M

更新日期：2006-10-01 00:00:00

abstract：:In Western countries, the age distribution of Hodgkin lymphoma (HL) follows a characteristic bimodal curve showing an early and a late peak at approximately 35 and 70 yr, respectively. Furthermore, the presence of latent Epstein-Barr virus (EBV) genome in the Hodgkin Reed-Sternberg cells, the tumour cell population of...

journal_title：European journal of haematology

authors： Ludvigsen M,Kamper P,Hamilton-Dutroit SJ,Bendix K,Møller MB,d'Amore FA,Honoré B

更新日期：2015-08-01 00:00:00

abstract：:Treatment with all-trans retinoic acid (ATRA) improves the prognosis of patients with acute promyelocytic leukemia (APL), but ATRA syndrome may occur as a possible fatal side effect, especially in cases refractory to medication or involving pulmonary hemorrhage. We describe two patients with APL who suffered from intr...

journal_title：European journal of haematology

authors： Kawasaki K,Akaike H,Miyauchi A,Ouchi K

更新日期：2006-11-01 00:00:00

abstract：:Lactoferrin, unlabelled or 125I-labelled by 2 different methods, was given intravenously to rats. Blood, tissue and liver cell radioactivity was measured. Both of the radiolabelled preparations were eliminated by the liver, and some deposited extrahepatically. One preparation formed large aggregates--here 90% of the h...

journal_title：European journal of haematology

authors： Peen E,Johansson A,Engquist M,Skogh T

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To assess the outcome of the measurement of apoptotic index in myeloma patients treated by conventional chemotherapy and novel drugs with biological mechanism of action, thalidomide and bortezomib. PATIENTS AND METHODS:In a cohort of 189 patients with newly diagnosed multiple myeloma from November 1997 throu...

journal_title：European journal of haematology

authors： Minarik J,Scudla V,Ordeltova M,Bacovsky J,Pika T,Langova K

更新日期：2009-12-01 00:00:00

abstract：:Implantation of Yoshida ascites sarcoma in rats was found to lead to a reduction in the hemoglobin content, the erythrocyte count and the packed cell volume of blood to 30% of normal in 4 d; however, there was no decrease in the mean cell hemoglobin, the mean cell volume and the mean corpuscular hemoglobin concentrati...

journal_title：European journal of haematology

authors： Bhanushali AA,Raghunathan R,Kalraiya RD,Mehta NG

更新日期：2002-01-01 00:00:00

abstract：:Infectious mononucleosis may occasionally be complicated by purpura, but the mechanism of the thrombocytopenia is not known in detail. In the present study, 3 children with mononucleosis-associated purpura were found to have marked elevations of platelet-associated immunoglobulins and circulating platelet binding IgG ...

journal_title：European journal of haematology

authors： Winiarski J

更新日期：1989-07-01 00:00:00

abstract：:We evaluated the serum/plasma levels of cytokines [interleukin (IL)-6, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-beta2] and markers of coagulation, fibrinolysis, endothelial and platelet activation during the first 4 wk of treatment with the thalidomide analogue Actimid (CC-4047) in 1...

journal_title：European journal of haematology

authors： Streetly M,Hunt BJ,Parmar K,Jones R,Zeldis J,Schey S

更新日期：2005-04-01 00:00:00

abstract：:MALT lymphoma is usually described in association with Helicobacter pylori, HCV, HHV8, Campylobacter jejuni or in a setting of overreactive immunity. In HIV(+) patients, MALT lymphoma is most commonly described in children. We describe here an original case of HIV(+) MALT lymphoma with bronchial, conjuctival and laryn...

journal_title：European journal of haematology

authors： Girard T,Luquet-Besson I,Baran-Marszak F,Raphaël M,Boué F

更新日期：2005-01-01 00:00:00

abstract：:An intensive protocol utilizing mitoxantrone, high-dose cytarabine, vincristine, etoposide and methylprednisolone as induction therapy for chronic myeloid leukemia in blast transformation is described. Fourteen patients were treated, with a remission/second chronic phase achieved in 64%. None of the 3 patients older t...

journal_title：European journal of haematology

authors： Lipton JH,Messner HA,Curtis JE,Atkins HL,Minden MD

更新日期：1996-07-01 00:00:00

abstract：:The development of an unusual case of primary pleural effusion in a 90-year-old human immunodeficiency virus (HIV)-negative Japanese woman with no identifiable tumor mass has been described. Pleural effusion specimens contained large diffuse lymphoma cells, with the phenotype and genotype of a B-cell lineage (positive...

journal_title：European journal of haematology

authors： Shimazaki M,Fujita M,Tsukamoto K,Matsuki T,Iwata M,Takahashi H,Doi A,Hyakkoku M,Yamauchi K,Genda S,Kikuiri T,Sakamoto T,Nojiri S,Ashie T

更新日期：2003-07-01 00:00:00

abstract：:A 1-yr-old Japanese male infant developed hepatitis-associated aplastic anemia (AA), and anti-thymocyte globulin (ATG) plus cyclosporine A (CsA) was administered without any appreciable effects. Laboratory examination of the patient's serum obtained before therapy revealed various autoantibodies, such as PA-IgG, anti-...

journal_title：European journal of haematology

authors： Takamatsu H,Yagasaki H,Takahashi Y,Hama A,Saikawa Y,Yachie A,Koizumi S,Kojima S,Nakao S

更新日期：2011-06-01 00:00:00

abstract：:Primary pancreatic lymphoma (PPL) is a rare disease representing 0.1% of malignant lymphomas, which lacks well-defined diagnostic and therapeutic protocols. OBJECTIVES:To describe PPL clinical, diagnostic and histological characteristics, together with therapy and outcome, in a relatively large series of patients. M...

journal_title：European journal of haematology

authors： Facchinelli D,Sina S,Boninsegna E,Borin A,Tisi MC,Piazza F,Scapinello G,Maiolo E,Hohaus S,Zamò A,Merli M,Stefani PM,Mellone F,Basso M,Sartori R,Rusconi C,Parisi A,Manfrin E,Krampera M,Ruggeri M,Visco C,Tecchio C

更新日期：2020-10-01 00:00:00

abstract：:There are established guidelines for treatment and monitoring of chronic myeloid leukemia (CML) but little is known about routine care. Data on ICD-10 codes as well as prescribed medications were available for 10.5 million patients in the statutory health insurance system in Bavaria for the years 2010 to 2016. Also, d...

journal_title：European journal of haematology

authors： Lauseker M,Gerlach R,Worseg W,Haferlach T,Tauscher M,Hasford J,Hoffmann VS

更新日期：2019-10-01 00:00:00