Antibodies to platelet membrane glycoprotein antigens in three cases of infectious mononucleosis-induced thrombocytopenic purpura.


:Infectious mononucleosis may occasionally be complicated by purpura, but the mechanism of the thrombocytopenia is not known in detail. In the present study, 3 children with mononucleosis-associated purpura were found to have marked elevations of platelet-associated immunoglobulins and circulating platelet binding IgG and IgM. Employing electrophoretically (SDS-PAGE) separated normal platelet membrane proteins in an immunoblot assay, serum IgG and IgM antibodies were found to be directed to antigenic determinants situated on glycoprotein GP IIb (140 kDa) in all patients, but also on smaller proteins of molecular weights between 30 and 52 kDa. 24 control sera were negative. Positive reactions were eliminated after absorption of sera with fresh platelets. These results demonstrate autoantibodies to platelet surface membrane proteins in infectious mononucleosis-induced purpura and suggest a transient autoantibody-mediated platelet destruction as the cause of thrombocytopenia in these patients.


Eur J Haematol


Winiarski J




Has Abstract


1989-07-01 00:00:00












  • Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning regimen in children: a single-center experience.

    abstract::This single-center retrospective study reported the outcome of 19 children treated with a reduced-intensity conditioning (RIC) regimen prior to allogeneic stem cell transplantation (allo-SCT), for hematologic malignancies (n = 17), bone marrow failure (n = 1), and neuroblastoma (n = 1). Children were ineligible for st...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Strullu M,Rialland F,Cahu X,Brissot E,Corradini N,Thomas C,Blin N,Rialland X,Méchinaud F,Mohty M

    更新日期:2012-06-01 00:00:00

  • Two beta-globin cluster-linked polymorphic loci in thalassemia patients of variable levels of fetal hemoglobin.

    abstract:OBJECTIVE:To correlate different polymorphisms of the beta-globin cluster with fetal hemoglobin (HbF) level in beta-thalassemia and E-beta thalassemia patients. METHODS:Fifteen thalassemia patients, seven with high HbF and not requiring transfusion, eight with lower HbF and requiring transfusion were studied for beta-...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Bandyopadhyay S,Mondal BC,Sarkar P,Chandra S,Das MK,Dasgupta UB

    更新日期:2005-07-01 00:00:00

  • PML-RARA fusion resulting from a cryptic insertion of RARA gene into PML gene without the reciprocal RARA-PML fusion: clinical, cytogenetic, and molecular characterization and prognosis.

    abstract::We describe a case of acute promyelocytic leukemia in a 61-yr-old woman with a cryptic insertion of RARA gene into PML gene. Using a combination of cytogenetic and molecular methods, we confirmed the insertion and presence of the PML-RARA transcript and lack of the reciprocal RARA-PML transcript. Although such cryptic...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Fan H,Ortega V,Fanasch HM,Wang Y,Holder KN,Higgins RA,Mendiola C,Mohamed G,Vadlamudi K,Velagaleti G

    更新日期:2014-10-01 00:00:00

  • Heterogeneity of in vitro growth pattern of megakaryocyte progenitors (CFU-M) in myeloproliferative disorders.

    abstract::In groups of 26 patients with myeloproliferative disorders (MPD), 8 with chronic myelogenous leukaemia (CML); 8 with polycythaemia vera (PV); 10 with essential thrombocythaemia (ET); and 6 patients with reactive thrombocytosis (RT), we studied the growth characteristics of bone marrow CFU-M in agar culture. The bone m...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Hamaguchi H,Takano N,Sakamaki H,Enokihara H,Saito K,Furusawa S,Shishido H

    更新日期:1988-08-01 00:00:00

  • Atypical hemoglobin H disease in a Thai patient resulting from a combination of alpha-thalassemia 1 and hemoglobin Constant Spring with hemoglobin J Bangkok heterozygosity.

    abstract::A case of hemoglobin H disease in combination with hemoglobin Constant Spring and a beta-globin chain variant is reported in a 3-yr-old Thai girl. On routine cellulose acetate electrophoresis, one abnormal band in addition to the hemoglobins A, A2, H, Bart's and Constant Spring was detected. The amount of this abnorma...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Fucharoen S,Ayukarn K,Sanchaisuriya K,Fucharoen G

    更新日期:2001-05-01 00:00:00

  • Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study.

    abstract:OBJECTIVE:A subset analysis of the randomised, phase 3, MDS-004 study to evaluate outcomes in patients with International Prognostic Scoring System (IPSS)-defined Low-/Intermediate (Int)-1-risk myelodysplastic syndromes (MDS) with isolated del(5q). METHODS:Patients received lenalidomide 10 mg/d (days 1-21; n = 47) or ...

    journal_title:European journal of haematology

    pub_type: 杂志文章,随机对照试验


    authors: Giagounidis A,Mufti GJ,Mittelman M,Sanz G,Platzbecker U,Muus P,Selleslag D,Beyne-Rauzy O,te Boekhorst P,del Cañizo C,Guerci-Bresler A,Nilsson L,Lübbert M,Quesnel B,Ganser A,Bowen D,Schlegelberger B,Göhring G,Fu T,Be

    更新日期:2014-11-01 00:00:00

  • Vitamin E and acute graft-versus-host disease after myeloablative allogeneic hematopoietic cell transplantation.

    abstract:OBJECTIVES:Vitamin E has antioxidant and immunomodulatory effects that might influence the development of acute graft-versus-host disease (GvHD). We investigated the association between plasma vitamin E levels and acute GvHD. METHODS:We studied 115 adults who underwent myeloablative allogeneic hematopoietic cell trans...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Gjaerde LK,Ostrowski SR,Minculescu L,Andersen NS,Friis LS,Kornblit B,Petersen SL,Schjødt I,Sengeløv H

    更新日期:2020-12-12 00:00:00

  • Small-dose oral iron absorption test in anaemic and non-anaemic elderly hospitalized patients.

    abstract::The small-dose (20 mg) oral iron absorption test (OIAT) was performed in 76 hospitalized elderly patients and 30 healthy adults. Of the elderly patients, 34 were considered as iron deficient (serum ferritin level < 20 micrograms/L) of whom 23 were anaemic and 11 not anaemic, 21 had the anaemia of chronic disorders (AC...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Joosten E,Vander Elst B,Billen J

    更新日期:1997-02-01 00:00:00

  • Chemotherapy followed by modified donor lymphocyte infusion as a treatment for relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion: superior outcomes compared with chemotherapy alone and a

    abstract::We retrospectively compared the antileukemic effects of chemotherapy alone and chemotherapy followed by modified donor lymphocyte infusion (DLI) in 82 patients with relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation (HSCT) without in vitro T-cell depletion. We also investigated progno...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Yan CH,Wang JZ,Liu DH,Xu LP,Chen H,Liu KY,Huang XJ

    更新日期:2013-10-01 00:00:00

  • Immunological typing of acute leukemias: immunoenzymatic staining of fixed cells compared with immunofluorescence staining of unfixed cells in suspension.

    abstract::A panel of 14 monoclonal antibodies (McAb) against hematopoietic cell surface antigens was applied on mononuclear blood or bone marrow cells from 40 cases of acute leukemia in order to compare immunoenzymatic staining (IE) (alkaline phosphatase) of fixed cells with immunofluorescence staining (IF) of unfixed suspended...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Ly B,Beiske K,Larsen N

    更新日期:1988-08-01 00:00:00

  • Two novel unstable hemoglobin variants due to in-frame deletions of key amino acids in the β-globin chain.

    abstract::Hemoglobinopathies are the most common autosomal recessive disorders and are mostly inherited in a recessive manner. However, certain mutations can affect the globin chain stability, leading to dominant forms of thalassemia. The aim of this work was the molecular and structural characterization of two heterozygous in-...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Scheps KG,Hasenahuer MA,Parisi G,Targovnik HM,García E,Veber ES,Crisp R,Elena G,Varela V,Fornasari MS

    更新日期:2018-06-01 00:00:00

  • A comparison of fluorine-18 fluoro-deoxyglucose PET and technetium-99m sestamibi in assessing patients with multiple myeloma.

    abstract:OBJECTIVE:The extent of disease in patients with multiple myeloma or related conditions may be difficult to assess. In previous small studies, both FDG-PET (PET) and Tc-99m sestamibi scans (MIBI) have identified sites of occult disease in myeloma. METHODS:We reviewed the results for patients at our institution who hav...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Mileshkin L,Blum R,Seymour JF,Patrikeos A,Hicks RJ,Prince HM

    更新日期:2004-01-01 00:00:00

  • Effectiveness of propagermanium treatment in multiple myeloma patients.

    abstract::Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the co...

    journal_title:European journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Tsutsumi Y,Tanaka J,Kanamori H,Musashi M,Minami H,Fukushima A,Yamato H,Ehira N,Kawamura T,Obara S,Ogura N,Asaka M,Imamura M,Masauzi N

    更新日期:2004-12-01 00:00:00

  • Genetic and other influences on red-cell flavin enzymes, pyridoxine phosphate oxidase and glutathione reductase in families with beta-thalassaemia.

    abstract::In 18 beta-thalassaemia families from the Ferrara area the incidence of an inherited low flavin mononucleotide (FMN)-dependent pyridoxine phosphate (PNP) oxidase activity, a sensitive indicator of red-cell FMN deficiency, is higher in related members in these families than in the unrelated spouses and controls subject...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Anderson BB,Perry GM,Clements JE,Studds C,Fashola R,Salsini G,Vullo C

    更新日期:1989-04-01 00:00:00

  • High levels of serum prostate-specific antigen due to PSA producing follicular non-Hodgkin's lymphoma.

    abstract:OBJECTIVE:Both carcinoma of the prostate and non-Hodgkin's lymphoma are common in elderly patients. Measurement of serum prostate-specific antigen (PSA) is a frequently used tool to diagnose and monitor prostate carcinoma and is generally specific for diseases of the prostate. CASE:We describe a 68-yr-old patient with...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Oosterheert JJ,Budel LM,Vos P,Wittebol S

    更新日期:2007-08-01 00:00:00

  • Synchronous FIP1L1-PDGFRA-positive chronic eosinophilic leukemia and T-cell lymphoblastic lymphoma: a bilineal clonal malignancy.

    abstract::Several reports of successful empirical treatment of idiopathic hypereosinophilic syndrome with imatinib led to the recent identification of the FIP1L1-PDGFRA fusion gene rearrangement, which characterizes a distinctive group of chronic eosinophilic leukemias. This fusion gene can be detected in eosinophils, neutrophi...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Capovilla M,Cayuela JM,Bilhou-Nabera C,Gardin C,Letestu R,Baran-Marzak F,Fenaux P,Martin A

    更新日期:2008-01-01 00:00:00

  • Effect of splenectomy on iron balance in patients with β-thalassemia major: a long-term follow-up.

    abstract:OBJECTIVE:A retrospective study was performed to explore the effect of splenectomy on iron balance in thalassemia major (TM). METHODS:Twenty two TM patients treated with splenectomy were compared with a control group (non-splenectomized patients) matched for sex, age, pretransfusional Hb, chelation therapy, and durati...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Casale M,Cinque P,Ricchi P,Costantini S,Spasiano A,Prossomariti L,Minelli S,Frega V,Filosa A

    更新日期:2013-07-01 00:00:00

  • Aberrant promoter methylation of Dab2 gene in myelodysplastic syndrome.

    abstract:OBJECTIVES:Human Disabled-2 (Dab2), a putative tumor suppressor gene, is frequently down-regulated in human tumors. This study aims to explore the association between Dab2 methylation status and expression in newly diagnosed myelodysplastic syndrome (MDS) patients and patients who received 5-aza-2'-deoxycytidine (decit...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Yang Y,Zhang Q,Xu F,Chang C,Li X

    更新日期:2012-12-01 00:00:00

  • External validation and clinical evaluation of the International Prognostic Score of Thrombosis for Essential Thrombocythemia (IPSET-thrombosis) in a large cohort of Chinese patients.

    abstract:OBJECTIVES:In patients with essential thrombocythemia (ET), vascular complications contribute to both morbidity and mortality. To better predict the occurrence of thrombotic events, an International Prognostic Score of thrombosis for ET (IPSET-thrombosis) was recently developed. We hereby presented an external validati...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Fu R,Xuan M,Lv C,Zhang L,Li H,Zhang X,Zhang D,Sun T,Xue F,Liu X,Liang H,Zhang L,Yang R

    更新日期:2014-06-01 00:00:00

  • Severe IgA-mediated auto-immune haemolytic anaemia in a 48-yr-old woman.

    abstract::Auto-immune haemolytic anaemia (AIHA) is characterised by haemolysis associated with the presence of the immunoglobulins IgG, IgM or IgA, and/or components of the complement system on the red cell membrane. The immunoglobulins react as auto-antibodies against the red cell antigens of the patient. IgG antibodies and th...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Bardill B,Mengis C,Tschopp M,Wuillemin WA

    更新日期:2003-01-01 00:00:00

  • Iron status in a multiethnic population (age 36-80 yr) in northern Norway: the SAMINOR study.

    abstract:OBJECTIVES:Northern Norway consists of a multiethnic population of Sámi and non-Sámi. We evaluated iron status in these two groups with respect to gender, age and residence. METHODS:In 2002-2004, a cross-sectional study of health and living conditions in areas with both Sámi and Norwegian populations, SAMINOR, was per...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Broderstad AR,Melhus M,Lund E

    更新日期:2007-11-01 00:00:00

  • Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival.

    abstract::Aberrant expression of genes regulating apoptosis/survival seems to be essential in the stepwise development of human multiple myeloma (MM). In this paper we have compared the expression of bcl-2 family pro- and anti-apoptotic genes in MM cell lines, primary MM cells and normal plasma cells. The Bcl-2, Mcl-1, Bcl-xL/S...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Spets H,Strömberg T,Georgii-Hemming P,Siljason J,Nilsson K,Jernberg-Wiklund H

    更新日期:2002-08-01 00:00:00

  • Combining counterflow centrifugal elutriation and glycoprotein Ib-dependent purification of human megakaryocytes: efficacy and selectivity.

    abstract::To estimate the efficacy of human megakaryocyte purification techniques, mixtures of known numbers of megakaryocytes with a known ploidy range and of bone marrow or peripheral blood mononuclear cells were made. These artificial bone marrow samples were submitted to either a counterflow centrifugal elutriation or Perco...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: van Pampus EC,van Geel BJ,Huijgens PC,Wijermans PW,Ossenkoppele GJ,Rodriguez F,Zevenbergen A,Langenhuijsen MM

    更新日期:1991-10-01 00:00:00

  • Over-expression of tumor necrosis factor-alpha in bone marrow biopsies from patients with myelodysplastic syndromes: relationship to anemia and prognosis.

    abstract:OBJECTIVES:An excessive intramedullar progenitor cell apoptosis, to which elevated expression of tumor necrosis factor-alpha (TNF-alpha) might contribute, is considered the main cause of inefficient hematopoiesis in myelodysplastic syndromes (MDS). Enhanced bone marrow (BM) angiogenesis is regarded as an essential cofa...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Stifter G,Heiss S,Gastl G,Tzankov A,Stauder R

    更新日期:2005-12-01 00:00:00

  • High-dose cyclophosphamide, etoposide and BCNU (CVB) with autologous stem cell rescue in malignant lymphomas.

    abstract::Eighteen patients with malignant lymphoma, 10 non-Hodgkin's and 8 Hodgkin's, were treated with high-dose CVB (cyclophosphamide 4 x 1.5 g/m2, etoposide 4 x 250-400 mg/m2, carmustine 4 x 150-200 mg/m2), followed by autologous peripheral blood stem cells (PBSC, 13 patients) or bone marrow (BM, 5 patients) transplantation...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Patti C,Majolino I,Scimè R,Indovina A,Vasta S,Liberti G,Gentile S,Santoro A,Pisa R,Caronia F

    更新日期:1993-07-01 00:00:00

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    abstract:OBJECTIVES:Interactions between hemopoietic cells and the stromal microenvironment or immunoreactive cells are mediated by specific cell surface receptors. The expression of those molecules may alter the adhesive qualities (mobility and homing) as well as immune response behavior of leukemic blasts. L-Selectin (CD62L) ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Graf M,Reif S,Hecht K,Pelka-Fleischer R,Pfister K,Nuessler V,Schmetzer H

    更新日期:2003-11-01 00:00:00

  • Neonatal isoimmune thrombocytopenia caused by type I CD36 deficiency having novel splicing isoforms of the CD36 gene.

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    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Taketani T,Ito K,Mishima S,Kanai R,Uchiyama A,Hirata Y,Kumakura S,Ishikura H,Yamaguchi S

    更新日期:2008-07-01 00:00:00

  • Rapid remineralization of multiple disseminated bone lesions after high-dose cytarabine in a patient with isolated myeloid sarcoma.

    abstract::Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Brähler S,Thielen I,Schwabe H,Engels M,Kreuzer KA,Wolf J,Ansén S

    更新日期:2014-06-01 00:00:00

  • Isolation and characterization of a tumor necrosis factor binding protein from urine.

    abstract::Tumor necrosis factor (TNF)/cachectin can produce both beneficial and harmful manifestations. Mechanisms may operate to counteract potentially harmful effects such as shock and cachexia. The TNF binding protein (TNF-BP), which is found at increased levels in serum and urine of patients with chronic renal failure, may ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: Olsson I,Lantz M,Nilsson E,Peetre C,Thysell H,Grubb A,Adolf G

    更新日期:1989-03-01 00:00:00

  • Splenectomy in patients with malignant lymphoma presenting with massive splenomegaly.

    abstract::6 patients with massive splenomegaly but no peripheral adenopathy were diagnosed by splenectomy as having lymphoma; and were found to have widespread disease. Despite the seriousness of their illness at presentation, all have survived for a median time of 101.5 months and reached complete remission. ...

    journal_title:European journal of haematology

    pub_type: 杂志文章


    authors: King DJ,Dawson AA,Thompson WD

    更新日期:1987-02-01 00:00:00