Reticulocyte crisis after splenectomy: evidence for delayed red cell maturation?

Abstract:

:In whole blood from splenectomized subjects (n = 8) in a steady state an increased number of reticulocytes was observed (14.0 +/- 7.8% versus 3.6 +/- 2.4% controls: p less than 0.05). Cell fractionation on density showed that reticulocytes, as in normals, are more or less confined to the least dense fraction; cell fractionation on volume revealed that reticulocytes form a heterogeneous cell population with diverging volume, but sharing a low density. Immediately after splenectomy (n = 4), a reticulocytosis is observed, mainly manifest in the top fractions (262.0 +/- 49.0% versus 40.0 +/- 32.4% preoperatively; p less than 0.01). This reticulocytosis is not due to pre- or postoperative complications, but is associated with the splenectomy itself and probably is the consequence of a delayed, but ultimately occurring red cell maturation. The increase of reticulocytes is not accompanied by significant alterations in cell morphology, as far as cell volume is concerned.

journal_name

Eur J Haematol

authors

De Haan LD,Werre JM,Ruben AM,Huls AH,de Gier J,Staal GE

doi

10.1111/j.1600-0609.1988.tb00872.x

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

74-9

issue

1

eissn

0902-4441

issn

1600-0609

journal_volume

41

pub_type

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