Relationship of intratumoural protein expression patterns to age and Epstein-Barr virus status in classical Hodgkin lymphoma.

abstract：BACKGROUND:Most viral infections are known to exert adverse effects on bone marrow function. However, certain viruses have recently been found to be therapeutically beneficial in the treatment of some malignant disorders. METHODS AND MATERIALS:A retrospective study was conducted at the Armed Forces Hospital, Riyadh, S...

journal_title：European journal of haematology

authors： Al-Anazi KA,Al-Jasser AM,Evans DA

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:Both carcinoma of the prostate and non-Hodgkin's lymphoma are common in elderly patients. Measurement of serum prostate-specific antigen (PSA) is a frequently used tool to diagnose and monitor prostate carcinoma and is generally specific for diseases of the prostate. CASE:We describe a 68-yr-old patient with...

journal_title：European journal of haematology

authors： Oosterheert JJ,Budel LM,Vos P,Wittebol S

更新日期：2007-08-01 00:00:00

abstract：:Immune thrombocytopenic purpura (ITP) is an autoimmune disorder, and high-dose dexamethasome (HD-DXM) has been used as a first-line therapy for patients with ITP. However, little is known about the role of dendritic cells (DCs) and CD4(+)Foxp3(+) regulatory T (Treg) cells in the pathogenesis of chronic ITP and the eff...

journal_title：European journal of haematology

authors： Ling Y,Cao X,Yu Z,Ruan C

更新日期：2007-10-01 00:00:00

abstract：:We compared the performance of the stroma (SL) and haematopoietic progenitors before (group A) or following cryopreservation from patients in complete remission (CR) of acute myeloid leukaemia before autologous transplantation (AML) (group B), to similarly treated normal cells (groups A and B). From each group, fibrob...

journal_title：European journal of haematology

authors： Novitzky N,Kruger W,Mohamed R

更新日期：1999-02-01 00:00:00

abstract：:Alkaline phosphatase (ALP) activity of 70 cases of non-Hodgkin's lymphomas of the B-cell type was studied. ALP activity was found in malignant lymphoma (ML), follicular, small cleaved cell (1/5 cases); ML, diffuse, small cleaved cell (3/13 cases); and mantle zone lymphoma (intermediate lymphocytic lymphoma) (2/2 cases...

journal_title：European journal of haematology

authors： Abe M,Nozawa Y,Wachi E,Tominaga K,Hojo H,Wakasa H

更新日期：1988-09-01 00:00:00

abstract：:Marrow fibroblast colony formation was studied in patients with myeloproliferative disorders, using human serum or platelet-derived growth factor plus plasma-derived serum as growth-stimulating factors. Colony numbers negatively correlated with the patient's age, but were not different from those of controls. However,...

journal_title：European journal of haematology

authors： Kimura A,Katoh O,Hyodo H,Kusumi S,Kuramoto A

更新日期：1990-05-01 00:00:00

abstract：:Chronic idiopathic neutropenia (CIN) is an acquired disorder of granulopoiesis characterized by increased apoptosis of the bone marrow (BM) granulocytic progenitor cells under the influence of pro-inflammatory mediators and oligoclonal/monoclonal T-lymphocytes. Because patients with immune-mediated BM failure display ...

journal_title：European journal of haematology

authors： Damianaki A,Stagakis E,Mavroudi I,Spanoudakis M,Koutala H,Papadogiannis F,Kanellou P,Pontikoglou C,Papadaki HA

更新日期：2016-12-01 00:00:00

abstract：:An intensive protocol utilizing mitoxantrone, high-dose cytarabine, vincristine, etoposide and methylprednisolone as induction therapy for chronic myeloid leukemia in blast transformation is described. Fourteen patients were treated, with a remission/second chronic phase achieved in 64%. None of the 3 patients older t...

journal_title：European journal of haematology

authors： Lipton JH,Messner HA,Curtis JE,Atkins HL,Minden MD

更新日期：1996-07-01 00:00:00

abstract：:Anaemia of inflammation (AI) is a frequent complication in patients suffering from chronic inflammatory disorders including infections, autoimmune and malignant disease. Cytokine imbalance with a shift towards T-helper (Th)1-type immune response seems to be important in the pathogenesis of this type of anaemia. Interf...

journal_title：European journal of haematology

authors： Weiss G,Schroecksnadel K,Mattle V,Winkler C,Konwalinka G,Fuchs D

更新日期：2004-02-01 00:00:00

abstract：:We report the case of an Epstein-Barr virus (EBV)- and human immunodeficiency virus-serum negative patient suffering from repeatedly relapsing classical Hodgkin's Lymphoma (cHL) associated with a histological picture of plasma cell-hyaline vascular (PC-HV) form of Castleman's disease (CD). The CD30- and CD15-positive,...

journal_title：European journal of haematology

authors： Falchi L,Capello D,Palumbo B,Rauco A,Emili R,Cianciulli M,Pace R,Capparella V,Liberati F,Liberati AM

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:Hepatocyte growth factor (HGF) is a constituent of the myeloma microenvironment and is elevated in sera from myeloma patients compared to healthy individuals. Increased levels of serum HGF predict a poor prognosis. It has previously been shown by us and others HGF can act as a growth factor to myeloma cells ...

journal_title：European journal of haematology

authors： Hov H,Tian E,Holien T,Holt RU,Våtsveen TK,Fagerli UM,Waage A,Børset M,Sundan A

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The occurrence of a thrombotic event in congenital bleeding disorders has drawn considerable attention in recent years. Both patients with hemophilia and patients with von Willebrand disease and even those with rare coagulation disorders have been shown to present occasional thrombotic events. Little is know...

journal_title：European journal of haematology

authors： Girolami A,Berti de Marinis G,Bertozzi I,Peroni E,Tasinato V,Lombardi AM

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:Extracellular vesicles (EVs) are important for intercellular signalling in cancer. Tumour-associated macrophages, expressing the haemoglobin-haptoglobin and mannose receptors CD163 and CD206, are crucial for cancer progression. We recently identified CD163 on EVs in the circulation as a fraction of total sol...

journal_title：European journal of haematology

authors： Kvorning SL,Nielsen MC,Andersen NF,Hokland M,Andersen MN,Møller HJ

更新日期：2020-05-01 00:00:00

abstract：:To investigate the role of protein phosphorylation in the early phase of EPO-mediated signal transduction, we EPO-stimulated a murine erythroid cell line ELM-I-1 transformed by plasmids comprised of the c-fos enhancer/promoter linked to the luciferase gene. Using this reporter gene system, we previously showed that EP...

journal_title：European journal of haematology

authors： Tsuda H,Huang RW,Takatsuki K

更新日期：1994-04-01 00:00:00

abstract：:Although targeted therapies are used increasingly in hematologic malignancies, we are unaware of any prior studies of radioimmunotherapy (RAIT) in B-acute lymphoblastic leukemia (ALL), even though this radiosensitive tumor expresses CD22, potentially a good target for this approach. Here, we report a patient with Phil...

journal_title：European journal of haematology

authors： Chevallier P,Bodet-Milin C,Robillard N,Eugene T,Menard A,Le Houerou C,Guillaume T,Delaunay J,Escoffre-Barbe M,Wegener WA,Goldenberg DM,Kraeber-Bodéré F

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The clinical severity in thalassaemia major (TM) depends on the underlying mutations of the beta-globin gene and the degree of iron overload. OBJECTIVE:The aim of the study was to investigate the impact of genotype on the development of endocrine complications in TM in our center. SUBJECTS AND METHODS:126 ...

journal_title：European journal of haematology

authors： Skordis N,Michaelidou M,Savva SC,Ioannou Y,Rousounides A,Kleanthous M,Skordos G,Christou S

更新日期：2006-08-01 00:00:00

abstract：:Treatment with all-trans retinoic acid (ATRA) improves the prognosis of patients with acute promyelocytic leukemia (APL), but ATRA syndrome may occur as a possible fatal side effect, especially in cases refractory to medication or involving pulmonary hemorrhage. We describe two patients with APL who suffered from intr...

journal_title：European journal of haematology

authors： Kawasaki K,Akaike H,Miyauchi A,Ouchi K

更新日期：2006-11-01 00:00:00

abstract：:Reduced-intensity conditioning regimens have demonstrated lower toxicity but increased relapse rates in the context of allogeneic hematopoietic stem cell transplantation (aSCT) for patients with acute myelogenous leukemia (AML). The FLAMSA- reduced-intensity conditioning (RIC) regimen, combining a cytoreductive and a ...

journal_title：European journal of haematology

authors： Holtick U,Shimabukuro-Vornhagen A,Chakupurakal G,Theurich S,Leitzke S,Burst A,Hallek M,von Bergwelt-Baildon M,Scheid C,Chemnitz JM

更新日期：2016-05-01 00:00:00

abstract：:Over the last two decades, the role of microRNAs has been extensively investigated, and it has become clear that these small non-coding RNAs play an essential role in several biological processes including erythropoiesis and that their dysregulation is associated with pathologies. Recent technical innovations have con...

journal_title：European journal of haematology

authors： Azzouzi I,Schmugge M,Speer O

更新日期：2012-07-01 00:00:00

abstract：:While cellular modulation in vitro of committed hematopoietic stem cell (HSC) growth has been known for some time, less is known about the effect of accessory cells (AC) on the growth of more immature HSC. We have examined the effect of peripheral blood (PB) AC on hematopoiesis by coculturing enriched PB CD34+ cells (...

journal_title：European journal of haematology

authors： Olesen G,Tønder H,Palshof T,Hokland P

更新日期：2002-02-01 00:00:00

abstract：:A 59-yr-old man developed fevers, shortness of breath, persistent cough and weight loss, shortly after initiation of therapy with interferon-alpha 2a and cytosine arabinoside for treatment of chronic myelogenous leukemia. Radiologic pulmonary infiltrates and lung tissue biopsy were consistent with bronchiolitis oblite...

journal_title：European journal of haematology

authors： Patel M,Ezzat W,Pauw KL,Lowsky R

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Secondary antibody deficiency (SAD), associated with severe, recurrent or persistent infections, is common in patients with haematological malignancies (HM), but unifying guidance on immunoglobulin replacement therapy (IgRT) in these patients is lacking. We aimed to develop consensus statements for the use o...

journal_title：European journal of haematology

authors： Jolles S,Michallet M,Agostini C,Albert MH,Edgar D,Ria R,Trentin L,Lévy V

更新日期：2021-01-16 00:00:00

abstract：:Intravascular lymphoma (IVL) is a rare type of extranodal lymphoma in which the lymphoma cells proliferate exclusively in lumina of small vessels. Here, we report a clinicopathological study of 13 cases IVL diagnosed at our institution between March 1999 and July 2007, and evaluated the clinical characteristics, usefu...

journal_title：European journal of haematology

authors： Matsue K,Asada N,Takeuchi M,Yamakura M,Kimura S,Odawara J,Aoki T

更新日期：2008-03-01 00:00:00

abstract：:A transgenic SCID (TG-SCID) mouse expressing the human cytokines interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) has been generated with the aim of making a model system allowing the in vivo proliferation of human hematopoietic cells. Using TG-SCID mice expressing high levels (30-35 ...

journal_title：European journal of haematology

authors： Kim DK,Kojima M,Fukushima T,Miyasaka M,Nakauchi H

更新日期：1998-08-01 00:00:00

abstract：INTRODUCTION:Lower risk myelodysplastic syndromes (MDSs) are characterised by increased apoptosis of haematopoietic cells in the bone marrow (BM). The mechanism driving this excessive apoptosis involves multiple immune molecules, including inflammatory cytokines such as interferon-γ (IFN-γ), tumour necrosis factor-α (T...

journal_title：European journal of haematology

authors： Zhang Z,Li X,Guo J,Xu F,He Q,Zhao Y,Yang Y,Gu S,Zhang Y,Wu L,Chang C

更新日期：2013-05-01 00:00:00

abstract：:Our aim was to assess liver iron content, in thalassaemic patients, by using three different MR protocols and compare their data. Ninety-four thalassaemic patients (44 M and 50 F, mean age 25.82 +/- 8.3 yrs), were enrolled in the study. In each patient, three measurements of the liver iron content were performed, with...

journal_title：European journal of haematology

authors： Christoforidis A,Perifanis V,Spanos G,Vlachaki E,Economou M,Tsatra I,Athanassiou-Metaxa M

更新日期：2009-05-01 00:00:00

abstract：:Soluble tumour necrosis factor receptors (sTNF-Rs) play a role as modulators of the biological function of tumour necrosis factor-alpha (TNF-alpha) in an agonist/antagonist pattern. In various pathologic states the production and release of sTNF-Rs may mediate host response and determine the course and outcome of dise...

journal_title：European journal of haematology

authors： Diez-Ruiz A,Tilz GP,Zangerle R,Baier-Bitterlich G,Wachter H,Fuchs D

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to evaluate the usefulness of serum osteocalcin (OC) levels in multiple myeloma (MM) in order to assess its significance and activity, and to predict its course. Serum OC was measurement in 117 patients with MM and 116 healthy controls matched for age and sex. Serum OC levels were weakly corr...

journal_title：European journal of haematology

authors： Mejjad O,Le Loët X,Basuyau JP,Ménard JF,Jego P,Grisot C,Daragon A,Grosbois B,Euller-Ziegler L,Monconduit M

更新日期：1996-01-01 00:00:00

abstract：:Externalization of phosphatidylserine (PS) is thought to contribute to sickle cell disease (SCD) pathophysiology. The red blood cell (RBC) aminophospholipid translocase (APLT) mediates the transport of PS from the outer to the inner RBC membrane leaflet to maintain an asymmetric distribution of PL, while phospholipid ...

journal_title：European journal of haematology

authors： Barber LA,Palascak MB,Qi X,Joiner CH,Franco RS

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Thalidomide is remarkably active in advanced relapsed and refractory multiple myeloma (MM), so that its use has been recently proposed either in newly diagnosed patients or as maintenance treatment after conventional or high-dose therapy. This latter therapeutic approach has risen the concern of side-effects ...

journal_title：European journal of haematology

authors： Tosi P,Zamagni E,Cellini C,Plasmati R,Cangini D,Tacchetti P,Perrone G,Pastorelli F,Tura S,Baccarani M,Cavo M

更新日期：2005-03-01 00:00:00